5 articles
Hemolytic disease of the newborn
Hemolytic disease of the newborn (HDFN, erythroblastosis fetalis): maternal IgG antibodies cross the placenta and destroy fetal red cells, mainly from RhD or ABO incompatibility; prevented by anti-D immunoglobulin, treated with phototherapy and transfusion.
Hemolytic disease of the newborn (ABO)
ABO hemolytic disease of the newborn (ABO HDN, ABO HDFN): neonatal hemolysis from maternal anti-A/anti-B IgG, almost always group O mother with A or B infant; usually mild jaundice treated with phototherapy.
Hydrops fetalis
Hydrops fetalis, including non-immune hydrops fetalis (NIHF), is abnormal fluid accumulation in two or more fetal compartments. Causes include aneuploidy, RASopathies, cardiac anomalies, and infection; survival often under 50%.
Kleihauer–Betke test
Kleihauer–Betke test (Kleihauer test, acid elution test): 1957 maternal blood assay detecting acid-resistant fetal HbF cells to quantify fetomaternal hemorrhage and guide Rho(D) immune globulin dosing in Rh D-negative women.
Rh disease
Rh disease, or Rh hemolytic disease of the fetus and newborn (erythroblastosis fetalis), occurs when an RhD-negative mother's anti-D IgG crosses the placenta and destroys RhD-positive fetal red cells; anti-D prophylaxis since 1968 has cut incidence about 95%.