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STI pathogens

39 articles

Tabes dorsalis

Tabes dorsalis (locomotor ataxia) is a rare late form of neurosyphilis from Treponema pallidum, causing demyelination of spinal posterior columns, lightning pains, ataxia, and Argyll Robertson pupils decades after infection.

Treponema pallidum

Treponema pallidum, the syphilis spirochete (Spirochaeta pallida), an obligate human spirochete bacterium discovered in 1905; subspecies pallidum, pertenue, and endemicum cause syphilis, yaws, and bejel, distinguished by a stealth outer membrane lacking lipopolysaccharide.

Trichomonas vaginalis

Trichomonas vaginalis, a flagellated protozoan parasite, causes trichomoniasis, the most common non-viral STI worldwide; about 156 million new cases in 2020, diagnosed by NAAT, treated with metronidazole.

Trichomoniasis

Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is the most common non-viral STI worldwide, with about 156 million new cases in 2020; treated with metronidazole or tinidazole, linked to HIV risk and preterm birth.

Ureaplasma parvum

Ureaplasma parvum, formerly U. urealyticum biovar 1, is a cell-wall-less human urogenital bacterium with serovars 1, 3, 6, 14, a 0.75–0.78 Mbp genome, and debated roles in preterm birth and neonatal lung disease.

Urethral discharge

Urethral discharge, also called urethral discharge syndrome, is abnormal urethral secretions, the hallmark of urethritis, usually from sexually transmitted Neisseria gonorrhoeae or Chlamydia trachomatis infection.

Vaginal discharge

Vaginal discharge, also called vaginal secretion or fluor vaginalis, is normal fluid that keeps the vagina clean and moist; a change in color, odor, or amount may signal infection.

Vaginitis

Vaginitis, also called vulvovaginitis, is inflammation or infection of the vagina causing itching, odor, and discharge. Main causes are bacterial vaginosis, candidiasis, trichomoniasis, and atrophic vaginitis; diagnosis requires testing, not history alone.

Venereal Disease Research Laboratory test

VDRL test (Venereal Disease Research Laboratory test): nontreponemal microscopic flocculation blood test for syphilis using cardiolipin, cholesterol, and phosphatidylcholine antigens; also the highly specific CSF-VDRL for neurosyphilis, distinct from RPR.