4 articles
Chronic recurrent multifocal osteomyelitis
Chronic recurrent multifocal osteomyelitis (CRMO), also called chronic nonbacterial osteomyelitis (CNO), is a rare autoinflammatory bone disease of children with recurrent sterile osteomyelitis, treated first with NSAIDs.
Majeed syndrome
Majeed syndrome (MJDS, OMIM 609628), also called LPIN2-related CRMO, a rare autosomal recessive autoinflammatory disease with early-onset chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia, and sometimes Sweet syndrome, treated with anti-IL-1 agents.
PAPA syndrome
PAPA syndrome (pyogenic arthritis, pyoderma gangrenosum, and acne; familial recurrent arthritis) is a rare autosomal dominant autoinflammatory disease caused by PSTPIP1 mutations on chromosome 15, driving IL-1β overproduction and treated with anakinra and TNF inhibitors.
SAPHO syndrome
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is a rare autoinflammatory bone-joint and skin disease, described by Chamot in 1987, affecting the anterior chest wall, treated with NSAIDs, bisphosphonates, and biologics.