264 articles
Tegileridine fumarate
Tegileridine fumarate (富马酸泰吉利定, SHR8554) is a Jiangsu Hengrui G protein-biased μ-opioid receptor agonist approved in China in January 2024 for moderate-to-severe postoperative pain, analgesia comparable to morphine.
Thenalidine
Thenalidine (thenophenopiperidine, AS 716, Sandostene) is a withdrawn piperidine H1-antihistamine introduced in 1953 for allergic and dermatologic conditions; severe neutropenia cases led to US withdrawal in 1958 and later withdrawals elsewhere.
Tiaprofenic acid
Tiaprofenic acid (Surgam, Albert Tiafen) is a propionic acid derivative NSAID (ATC M01AE11) for rheumatic disease and pain, dosed 600 mg daily, distinguished by a cystitis adverse effect and dysmenorrhea efficacy.
Tinoridine
Tinoridine (Y-3642) is a thienopyridine non-steroidal anti-inflammatory drug developed by Yoshitomi Pharmaceutical, inhibiting COX enzymes and also scavenging hydroxyl radicals; half-life about 8.2 hours orally.
Topical corticosteroid therapy
Topical corticosteroid therapy is the application of corticosteroid medications to the skin to treat dermatoses such as atopic dermatitis, psoriasis, and lichen planus, with agents ranging from hydrocortisone to superpotent clobetasol.
Tranilast
Tranilast (Rizaben, トラニラスト) is an antiallergic, antifibrotic mast-cell stabilizer that suppresses TGF-β; approved in Japan, South Korea, and China for asthma and keloids, and in EMA/FDA orphan development for IPF.
Triamcinolone
Triamcinolone, sold as Nasacort and Kenalog among other brands, is a corticosteroid drug used as a cream, nasal spray, dental paste, and injection to treat inflammation.
Triamcinolone acetonide
Triamcinolone acetonide (Kenalog, Nasacort) is a synthetic glucocorticoid, five times as potent as cortisol, used intralesionally for keloids, as nasal spray for allergies, and intra-articularly for joint disease.
Triamcinolone hexacetonide
Triamcinolone hexacetonide (Aristospan, Hexatrione 2%) is a long-acting, poorly soluble intra-articular corticosteroid suspension preferred for joint injections in juvenile idiopathic arthritis, with longer relapse-free response than triamcinolone acetonide.
Trioxsalen
Trioxsalen (trioxysalen, trimethylpsoralen, TMP, Trisoralen) is a synthetic psoralen (C14H12O3, CAS 3902-71-4) used with UVA in PUVA photochemotherapy, mainly for vitiligo and in Scandinavian bath PUVA for psoriasis; US oral product discontinued in 2002.
Tripelennamine
Tripelennamine (Pyribenzamine) is a first-generation ethylenediamine H1-antihistamine approved by the FDA in 1948 for itching, hay fever, rhinitis, asthma, and urticaria; systemic forms are discontinued, with a 1% topical cream marketed since 2025.
Triprolidine
Triprolidine is a first-generation H1 antihistamine developed in the 1950s for allergic rhinitis and cold symptoms, used almost always in combination with pseudoephedrine in products like Actifed.
Tritoqualine
Tritoqualine (Hypostamine, Livalfa, Inhibostamin), ATC R06AX21, is an isoquinoline histidine decarboxylase inhibitor with no H1 receptor action, used for allergic rhinitis and studied for anesthesia-related histamine reactions.
Tylenol (brand)
Tylenol, the acetaminophen pain-relief brand launched by McNeil Laboratories in 1955, owned by Johnson & Johnson from 1959 and Kenvue since 2023, now being acquired by Kimberly-Clark and facing autism-claim litigation.
U-47700
U-47700 (trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide) is a non-fentanyl synthetic opioid, a selective μ-opioid receptor agonist developed by Upjohn in the 1970s, about 7.5 times more potent than morphine, linked to overdose deaths and scheduled in Schedule I (US CSA, 2016; UN Single Convention 61/I, 2017).
Vamorolone
Vamorolone (Agamree, VBP15) is a dissociative corticosteroid approved in 2023 in the US and EU for Duchenne muscular dystrophy in patients 2 years and older, dosed 6 mg/kg daily, with fewer growth and bone side effects than prednisone or deflazacort.
VC005 (JAK1 inhibitor)
VC005 is a second-generation, highly selective JAK1 inhibitor by Jiangsu Vcare, developed as an oral tablet and topical gel for atopic dermatitis, ankylosing spondylitis, vitiligo, and rheumatoid arthritis, with picomolar JAK1 potency and reduced JAK2 activity.
Vixotrigine
Vixotrigine (BIIB074, CNV1014802, formerly raxatrigine) is an investigational voltage- and use-dependent sodium channel blocker for neuropathic pain, developed by Biogen/Convergence; phase 2 trials in trigeminal neuralgia and small fibre neuropathy gave mixed results.
WHO analgesic ladder
The WHO analgesic ladder is a 1986 World Health Organization guideline for cancer pain that escalates from non-opioids to weak opioids to strong opioids as pain worsens.
Xiao'er Niuhuang Tuire patch
Xiao'er Niuhuang Tuire patch (小儿牛黄退热贴膏), a class 1.1 TCM gel patch approved by NMPA in April 2025 by Jianmin Group, treats fever ≤38.5°C from wind-heat AURI in children 1–5 via Dazhui and Shenque acupoint application.
Yangxue Qufeng Zhitong granules
Yangxue Qufeng Zhitong granules (养血祛风止痛颗粒) is a traditional Chinese medicine approved in China in June 2025 as the first innovative TCM for frequent episodic tension-type headache.
Zomepirac
Zomepirac (Zomax), a pyrrole-acetic acid NSAID related to tolmetin, was an oral nonopioid analgesic for mild to severe pain, comparable to IM morphine, withdrawn worldwide in March 1983 after fatal anaphylactoid reactions.
Zucapsaicin
Zucapsaicin (civamide), the synthetic cis-isomer of capsaicin, is a TRPV1 agonist analgesic; a 0.075% cream (Civanex/Zuacta) was approved in Canada in 2010 for severe knee osteoarthritis pain, and intranasal civamide was studied for migraine and cluster headache.
ZYI1
ZYI1 (ZYI-1) was a Zydus Cadila small-molecule drug candidate for inflammation and pain, in Phase II trials by 2009; its mode of action was never disclosed and the program was abandoned in Phase 2.