6 articles
Abametapir
Abametapir (HA-44, Xeglyze/XEGLYZE) is a 5,5'-dimethyl-2,2'-bipyridine metalloproteinase-inhibitor pediculicide; a 0.74% lotion FDA-approved in 2020 for single-application head lice treatment.
Amoscanate (nithiocyamine)
Amoscanate (nithiocyamine, CGP 4540), a Ciba-Geigy isothiocyanate diphenylamine antischistosomal drug, was widely used against S. japonicum in China but limited by liver damage and cardiac arrhythmias; superseded by praziquantel.
Bithionol
Bithionol (Bitin, Actamer), a chlorinated bisphenol anthelmintic, treated Fasciola, Paragonimus, and tapeworm infections before photosensitivity led to its 1967 FDA withdrawal; now obsolete as a drug but studied for antibacterial and anticancer repurposing.
Oltipraz
Oltipraz (RP 35972), a synthetic dithiolethione once marketed by Rhone-Poulenc for schistosomiasis, is an Nrf2-activating Phase II enzyme inducer studied as a cancer chemopreventive and NAFLD drug.
Pyrantel
Pyrantel (pyrantel pamoate) is a tetrahydropyrimidine anthelmintic, a nicotinic acetylcholine agonist, used OTC for pinworm at 11 mg/kg and against soil-transmitted helminths; resistance reported in Ancylostoma caninum.
Triclabendazole
Triclabendazole (Egaten, Fasinex) is a benzimidazole anthelmintic active against immature and adult Fasciola liver flukes and Paragonimus; WHO's only recommended fascioliasis drug, FDA-approved 2019, with livestock resistance reported since the mid-1990s.