5 articles
Apricitabine
Apricitabine (ATC; formerly AVX754, SPD754, BCH10618) is an investigational deoxycytidine analogue NRTI for HIV-1, active against M184V and thymidine analogue mutation virus; Avexa halted its phase III development in 2010 without approval.
Didanosine
Didanosine (ddI, Videx, dideoxyinosine), an NRTI antiretroviral for HIV-1; second FDA-approved HIV drug (9 October 1991); withdrawn from U.S. market due to pancreatitis, neuropathy, and mitochondrial toxicity.
Islatravir
Islatravir (MK-8591, EFdA), Merck's nucleoside reverse transcriptase translocation inhibitor for HIV-1; 2021 FDA clinical holds over lymphocyte declines; approved 2026 as IDVYNSO with doravirine; once-weekly ISL/LEN in Phase 3.
Tenofovir alafenamide
Tenofovir alafenamide (TAF, GS-7340, Vemlidy) is a prodrug of tenofovir, an FDA-approved HBV nucleotide reverse transcriptase inhibitor also used in HIV fixed-dose combinations such as Biktarvy and Descovy, delivering 90% lower plasma tenofovir than TDF with better renal and bone safety.
Zalcitabine
Zalcitabine (ddC, 2′,3′-dideoxycytidine, Hivid) was Roche's nucleoside reverse transcriptase inhibitor, FDA-approved in 1992 with zidovudine for advanced HIV; limited by peripheral neuropathy and stomatitis, discontinued December 31, 2006.