5 articles
DB-1324
DB-1324 is a CDH17-targeting antibody-drug conjugate from Duality Biologics' DITAC platform, optioned to GSK in December 2024 for up to $975 million in milestones, now in a Phase 1/2 first-in-human gastrointestinal tumor trial.
Etuvetidigene autotemcel
Etuvetidigene autotemcel (Waskyra, etu-cel) is an autologous lentiviral HSPC gene therapy for Wiskott-Aldrich syndrome, approved by FDA December 9, 2025 and EMA January 9, 2026, marketed by Fondazione Telethon.
Felzartamab
Felzartamab (MOR202, TJ202) is a fully human anti-CD38 IgG1 monoclonal antibody by Biogen that depletes plasma cells and NK cells; in phase 2 trials it resolved antibody-mediated kidney-transplant rejection and reduced proteinuria in membranous nephropathy and IgA nephropathy.
Tecotabart vedotin
Tecotabart vedotin (LM-302, TPX-4589) is LaNova Medicines' anti-CLDN18.2 antibody-drug conjugate carrying MMAE via a cleavable linker, in priority review in China for CLDN18.2-positive gastric/gastroesophageal junction adenocarcinoma after two prior lines.
Zenocutuzumab
Zenocutuzumab-zbco (Bizengri, MCLA-128) is a bispecific HER2/HER3 antibody by Merus and Partner Therapeutics for NRG1 fusion-positive NSCLC, pancreatic adenocarcinoma, and cholangiocarcinoma; FDA-approved 2024 and 2026.