13 articles
Bunamiodyl
Bunamiodyl (buniodyl, Orabilex) was a tri-iodinated oral cholecystographic contrast agent introduced in 1958 and withdrawn from Canadian, US, and UK markets in 1963 after causing acute renal failure with tubular necrosis.
Cornell dots
Cornell dots, also called C dots or C' dots, are ultrasmall fluorescent silica nanoparticles developed at Cornell University in 2005 to light up cancerous tumors for surgeons.
Exametazime
Exametazime (HMPAO, hexamethylpropylene amine oxime) is a ketoxime chelator for technetium-99m, marketed as the Ceretec kit (US approval 1988), used for Tc-99m brain perfusion SPECT in stroke and for labeling autologous leukocytes to image infection.
Floretyrosine F 18 (Pixclara)
Pixclara (floretyrosine F 18, 18F-FET, TLX101-Px) is Telix's fluorine-18 tyrosine PET tracer, FDA-approved in 2026 (NDA 218592) to differentiate recurrent or progressive glioma from treatment-related change via LAT1/LAT2 uptake.
Flurpiridaz
Flurpiridaz (Flyrcado, flurpiridaz F 18, BMS-747158) is an FDA-approved (September 27, 2024) fluorine-18 PET myocardial perfusion radiotracer binding mitochondrial complex I, with 109-minute half-life and 94% extraction fraction, used to detect coronary artery disease.
Gadoteridol
Gadoteridol (ProHance, Bracco) is a macrocyclic gadolinium-based MRI contrast agent, FDA-approved in 1992, dosed at 0.1 mmol/kg, indicated for CNS MRI including term neonates and adult head and neck MRI, with low NSF risk.
Gallium Ga-68 gozetotide kit (Illuccix)
Illuccix (TLX591-CDx), Telix Pharmaceuticals' kit for preparing gallium Ga-68 gozetotide (PSMA-11) injection, a PSMA-targeted PET radiopharmaceutical for prostate cancer imaging; TGA-approved November 2021, FDA-approved December 2021, three-vial kit in two configurations.
Iofetamine
Iofetamine (iofetamine hydrochloride I-123, IMP, brand SPECTAMINE) is an iodine-123-labeled amphetamine analog radiopharmaceutical for cerebral perfusion SPECT, later eclipsed by 99mTc-HMPAO and 99mTc-ECD.
Ioversol
Ioversol, marketed as Optiray, is a nonionic, low-osmolar iodinated X-ray contrast agent approved in 1988 for angiography, CT of the head and body, venography, and urography.
Ioxilan
Ioxilan (Oxilan) is a nonionic, low-osmolar, triiodinated X-ray contrast agent approved by the FDA in 1995 (NDA 020316) for urography, CT, and arteriography; later discontinued.
Perfluorocarbon nanoemulsions
Perfluorocarbon nanoemulsions (PFC nanoemulsions) are submicrometer emulsions of inert liquid perfluorocarbon droplets in water, first studied as artificial blood and later used for 19F MRI tracers and targeted drug delivery.
Phase-change perfluorocarbon nanodroplets
Phase-change perfluorocarbon nanodroplets (PFCnDs) are submicrometer liquid perfluorocarbon particles that ultrasound or laser light converts into gas microbubbles, enabling on-demand contrast imaging and drug delivery.
Superparamagnetic iron oxide nanoparticles
Superparamagnetic iron oxide nanoparticles (SPIONs) are nanoscale iron oxide crystals, usually magnetite or maghemite, coated for biocompatibility and used as MRI contrast agents, drug carriers, and heat mediators in magnetic hyperthermia.