32 articles
Tissue Distribution
Tissue distribution (MeSH D014018): accumulation of a drug or chemical in body organs, expressed as tissue-to-plasma ratios; governed by perfusion, membrane permeability, protein binding, and barriers like the blood-brain barrier.
Volume of distribution
Volume of distribution (Vd), apparent volume of distribution, Vd(area) and Vd(ss): pharmacokinetic ratio of drug amount in body to plasma concentration; determines loading dose and half-life; altered by protein binding, lipophilicity, obesity, kidney disease, pregnancy.