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Hemolytic anemia due to glucophosphate isomerase deficiency
Hemolytic anemia due to glucophosphate isomerase deficiency, also known as GPI deficiency, is a rare inherited anemia beginning in infancy, caused by a faulty glycolytic enzyme.
Hemolytic anemia due to pyrimidine 5' nucleotidase deficiency
Hemolytic anemia due to pyrimidine 5' nucleotidase deficiency (P5N deficiency, UMPH1 deficiency, CNSHA8, OMIM 266120): rare autosomal recessive NT5C3A red cell enzymopathy with mild-moderate hemolytic anemia, basophilic stippling, and erythrocyte pyrimidine nucleotide accumulation; also mimicked by lead poisoning.
Hemolytic anemia from infection and toxins
Hemolytic anemia from infection and toxins is the accelerated destruction of red blood cells caused by infectious organisms, notably malaria, or by toxins including snake venom, copper, and lead.
Hemolytic disease of the newborn
Hemolytic disease of the newborn (HDFN, erythroblastosis fetalis): maternal IgG antibodies cross the placenta and destroy fetal red cells, mainly from RhD or ABO incompatibility; prevented by anti-D immunoglobulin, treated with phototherapy and transfusion.
Hemolytic disease of the newborn (ABO)
ABO hemolytic disease of the newborn (ABO HDN, ABO HDFN): neonatal hemolysis from maternal anti-A/anti-B IgG, almost always group O mother with A or B infant; usually mild jaundice treated with phototherapy.
Hemolytic Plaque Technique
Hemolytic plaque technique (Jerne plaque assay, plaque-forming cell assay): 1963 Jerne and Nordin method counting single antibody-secreting cells by complement lysis of sheep red blood cells in agar; predecessor of ELISPOT.
Hemolytic–uremic syndrome
Hemolytic–uremic syndrome (HUS), also called atypical HUS (aHUS) in its complement-mediated form, is a thrombotic microangiopathy with thrombocytopenia, hemolytic anemia, and kidney injury; STEC-HUS follows Shiga toxin E. coli, aHUS follows complement dysregulation treated with eculizumab or ravulizumab.
HEMOPEC trial
HEMOPEC (NCT07070973) is a pilot trial at Gemelli in Rome testing AI-guided Assisted Fluid Management and Hypotension Prediction Index against goal-directed therapy during cytoreductive surgery with HIPEC for ovarian cancer, 52 women, 2025-2027.
Hemoperfusion
Hemoperfusion is an extracorporeal treatment that passes anticoagulated blood through a column of activated charcoal or resin beads to remove poisons, toxins, and inflammatory mediators.
Hemopericardium
Hemopericardium, or hemorrhagic pericardial effusion, is blood accumulating in the pericardial sac, risking cardiac tamponade. Leading causes: invasive cardiac procedures (~31%), aortic dissection, trauma, malignancy, infection, anticoagulants; diagnosed by echocardiography and high-attenuation CT fluid.
Hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH), including familial HLH and macrophage activation syndrome, is a life-threatening hyperinflammatory cytokine storm syndrome diagnosed by HLH-2004 criteria or HScore, treated with etoposide, steroids, emapalumab, and HSCT, with about 50% adult mortality.
Hemophagocytic syndrome associated with an infection
Infection-associated hemophagocytic syndrome (IAHS), or reactive hemophagocytic syndrome, is secondary hemophagocytic lymphohistiocytosis triggered by a concurrent infection, most often Epstein-Barr virus; diagnosis uses HLH-2004 criteria or HScore, and treatment targets the infectious trigger.
Hemoporfin for injection (Fumeida)
Hemoporfin for injection (Fumeida, 复美达), also called HMME (hematoporphyrin monomethyl ether), is a Chinese class 1.1 photodynamic drug approved in 2016; the first drug worldwide for port-wine stain, given intravenously with 532 nm laser irradiation.
Hemoptysis
Haemoptysis (hemoptysis) is coughing up blood from the lower respiratory tract; 5–14% of cases are life-threatening, usually from bronchial arteries, treated with bronchial artery embolization.
Hemorrhagic fever-renal syndrome
Hemorrhagic fever with renal syndrome (HFRS), also called Korean hemorrhagic fever or epidemic hemorrhagic fever, is a rodent-borne hantavirus disease of Europe and Asia causing fever, hemorrhage, and acute kidney injury, with case fatality from under 1% (Puumala) to 15% (Hantaan).
Hemorrhoid
Hemorrhoids (piles): symptomatic engorgement of the normal anal cushions. Covers Goligher grading I–IV, prevalence (17–31%), fiber evidence, banding versus surgery, 2024 ASCRS guideline shift, and embolization.
Hemorrhoidectomy
Hemorrhoidectomy is the surgical excision of hemorrhoidal tissue, considered the gold standard for grade III–IV hemorrhoids; its main variants are the closed Ferguson technique and the open Milligan–Morgan operation.
HEMOSTA-PN trial
HEMOSTA-PN (NCT07232927) is a randomized single-center trial at Ankara University testing FloSeal and Surgicel versus suturing alone in 150 patients undergoing partial nephrectomy for T1a-T1b renal tumors, 2023-2024.
Hemostasis
Hemostasis, the arrest of bleeding from injured vessels, involves vascular constriction, platelet plug formation, and coagulation; explained by the classic cascade and the modern cell-based model of Hoffman and Monroe.
Hemostat
Hemostat (hemostatic forceps, artery forceps): a ratcheted locking surgical clamp with ring handles used to compress blood vessels and stop bleeding; types include Crile, Kelly, Halsted mosquito, and Kocher; developed from Péan's and Spencer Wells' artery forceps.
Hemostatic Techniques
Hemostatic techniques are methods for controlling bleeding: pressure, ligation, clips, cautery, topical hemostatic agents, embolization, endoscopic and surgical hemostasis, and anticoagulation reversal (MeSH D006489).
Hemothorax
Hemothorax: blood accumulating in the pleural space, usually from blunt or penetrating chest trauma. Diagnosed by chest radiograph, E-FAST, or CT; treated with tube thoracostomy, VATS for retained blood, or thoracotomy when bleeding exceeds 1500 mL.
Henagliflozin proline
Henagliflozin proline (脯氨酸恒格列净, brand name Ruiqin) is an oral SGLT2 inhibitor by Jiangsu Hengrui Pharmaceuticals, approved in China in 2021 and described as the first SGLT2 inhibitor developed independently there.
Hendra virus infection
Hendra virus infection, caused by Hendra virus (HeV, equine morbillivirus), a bat-borne henipavirus in Australia; flying-fox reservoir, horse amplifying host, 7 human cases with 4 deaths, horse vaccine Equivac HeV, no human vaccine.
Hengrui Pharma (恒瑞医药)
Hengrui Pharma (恒瑞医药), formally Jiangsu Hengrui Pharmaceuticals, is a Chinese pharmaceutical company founded in 1970 and headquartered in Lianyungang, Jiangsu, focused on oncology and listed in Shanghai and Hong Kong.
Henipavirus encephalitis
Henipavirus encephalitis is brain inflammation caused by Nipah or Hendra virus (genus Henipavirus, Paramyxoviridae), bat-borne zoonoses with 40–75% case fatality, relapsing encephalitis, no licensed treatment, and vaccine candidates in trials.
Henk Lamberts
Henk Lamberts was a Dutch general practitioner and professor at the University of Amsterdam, internationally known as the leading developer of the International Classification of Primary Care.
Henlius rituximab biosimilar (HLX01, Hanlikang)
HLX01, sold in China as Hanlikang (汉利康), is a rituximab biosimilar developed by Shanghai Henlius Biotech and approved in 2019 as the first biosimilar approved in China.
Henlius trastuzumab biosimilar (HLX02, Hanquyou)
HLX02 (Hanquyou 汉曲优, Zercepac, HERCESSI) is Shanghai Henlius's trastuzumab biosimilar for HER2-positive breast and gastric cancers, the first China-made monoclonal antibody biosimilar approved in China, the EU, and the US.
Hennekam syndrome
Hennekam syndrome, also called Hennekam lymphangiectasia-lymphedema syndrome, is a rare inherited disorder of lymphatic development featuring congenital lymphedema, intestinal lymphangiectasia, variable intellectual disability, and a distinctive face.