25,729 articles
Latozinemab
Latozinemab (AL001) is Alector's human IgG1 anti-sortilin antibody meant to raise progranulin in FTD-GRN. It elevated PGRN 165% in the phase 3 INFRONT-3 trial but failed its clinical endpoint; development was discontinued in 2025.
Latrepirdine
Latrepirdine (Dimebon, dimebolin), a Soviet 1983 antihistamine repurposed for Alzheimer's and Huntington disease; strong phase II results led to a Pfizer deal, but phase III trials failed.
Latrine
Latrine: a pit-based facility for disposing of human excreta, including simple pit, VIP, and twin-pit latrines. Used by about 1.77 billion people; distinct from flush toilets and open defecation.
Lattice corneal dystrophy type I
Lattice corneal dystrophy type I (LCD1, Biber-Haab-Dimmer, classic lattice corneal dystrophy) is a rare autosomal dominant TGFBI (5q31, R124C) amyloid stromal corneal dystrophy causing lattice lines, erosions, and vision loss from the first decade, treated with PTK or keratoplasty.
Laubry-Pezzi syndrome
Laubry-Pezzi syndrome, or ventricular septal defect with aortic insufficiency, is a rare congenital heart malformation in which an aortic cusp prolapses into a VSD via the Venturi effect, causing aortic regurgitation; described by Laubry and Pezzi in 1921.
Laudanum
Laudanum, an alcoholic tincture of opium, was named by Paracelsus in the 16th century and popularized by Thomas Sydenham's 1667 recipe; it dominated Victorian home medicine, caused widespread poisoning deaths, and survives as Schedule II opium tincture.
Laughter Therapy
Laughter therapy (humor therapy): complementary therapy using humor, laughter exercises, laughter yoga, and clowning to improve well-being; MeSH D027641, introduced 2002; meta-analyses show moderate mental health benefits with low study quality.
Lauha Parpati
Parpati Lauha (Lauha Parpati, लौहपर्पटी) is an Ayurvedic herbo-mineral flake medicine of Kajjali (mercury-sulphur) with Lauha Bhasma, used for malabsorption, anaemia, and digestive disorders; AFI Part 1 formulation 16:4, no expiry date assigned.
Laura Delano
Laura Delano, American writer and consultant, ex-psychiatric patient of 14 years, founder of Inner Compass Initiative (2018) and author of the 2025 memoir Unshrunk; not a physician, distinct from any namesake.
Laurence Auzière-Jourdan
Laurence Auzière-Jourdan (born Laurence Auzière, 1977) is a French cardiologist in Nogent-sur-Marne, daughter of Brigitte Macron and stepdaughter of President Emmanuel Macron; married to radiologist Guillaume Jourdan, she keeps a low public profile.
Laurence E. Earley
Laurence E. Earley, also known as Laurence Elliott Earley, was an American nephrologist who chaired medicine at the University of Pennsylvania from 1977 to 1990.
Laurence-Moon syndrome
Laurence-Moon syndrome (LMS, OMIM 245800, ORPHA 2377) is a very rare autosomal recessive PNPLA6-related disorder with progressive spastic paraplegia, chorioretinal dystrophy, and hypogonadism, distinct from Bardet-Biedl syndrome.
Laurie M. Gunter
Laurie Martin Gunter was an American gerontological nursing researcher and academic administrator who headed the Department of Nursing at Penn State from 1971 to 1976.
Laurin-Sandrow syndrome
Laurin-Sandrow syndrome (Sandrow syndrome, tetramelic mirror-image polydactyly, OMIM 135750) is an extremely rare autosomal dominant congenital disorder with polysyndactyly of the hands, mirror feet, nasal defects, and ulnar/fibular duplication, caused by ZRS microduplications on 7q36.3.
Lavanabhaskara curna
Lavanabhaskara curna (लवणभास्कर चूर्ण), also written Lavan Bhaskar Churna, is an Ayurvedic salt-based powder with 17 ingredients, used for indigestion, loss of appetite, and abdominal distension, recorded in the Sharangdhar Samhita.
Lavangadi Curna
Lavangadi Curna (Lavaṅgādi cūrṇa) is a classical Ayurvedic clove-based polyherbal powder in the Ayurvedic Formulary of India, dosed 5-10 g, studied clinically in Amavata and Grahani (IBS).
Lavangadi Vati
Lavangadi Vati (Lavaṅgādi vaṭī) is a classical Ayurvedic clove-based pill listed in the Ayurvedic Formulary of India (AFI000403), made with clove, black pepper, bibhitaka, khadira, and babbula, used for cough and dyspnea at a 1 g dose.
Lavender aromatherapy
Lavender aromatherapy is a complementary clinical method delivering essential oil of Lavandula angustifolia by inhalation, bath, or oral capsule to reduce anxiety, pain, and sleep disturbances, though trial evidence is of low average quality.
Lawrence S. Lewin
Lawrence S. Lewin (1938–2012) was an American health policy consultant who founded The Lewin Group, a Washington-based consulting firm, and was elected to the Institute of Medicine in 1984.
Lawrence W. Green
Lawrence W. Green is an American health education scholar and Professor Emeritus at UCSF, originator of the PRECEDE-PROCEED planning model and first Director of the federal Office of Health Promotion.
Laxative
Laxatives are medicines that help pass stools, used for constipation, bowel preparation, and opioid-related constipation. Four main types (bulk-forming, osmotic, stool softener, stimulant) differ in onset from 6 hours to 3 days; overuse risks dependency.
Layer-by-layer nanoparticles
Layer-by-layer nanoparticles are drug-delivery particles built by sequentially adsorbing oppositely charged polymers or lipids onto a colloidal core, used mainly in cancer therapy and gene delivery.
Lazar J. Greenfield Sr.
Lazar J. Greenfield Sr. is an American vascular surgeon who developed the Greenfield vena cava filter, introduced in 1973, and later chaired surgery at the University of Michigan.
Lazarus and Joannes Baptista Colloredo
Lazarus and Joannes Baptista Colloredo were Italian conjoined twins born in Genoa in 1617; Lazarus carried his malformed parasitic twin, and they toured Europe as performers.
Lazarus sign
Lazarus sign: complex spinally mediated arm-flexion movement in brain-dead patients, named by Ropper 1984, occurring in about 2% during apnea testing or ventilator withdrawal; does not invalidate brain-death diagnosis.
Lazarus syndrome
Lazarus syndrome, or autoresuscitation, is the delayed unassisted return of spontaneous circulation minutes after CPR is stopped and death declared; about 76 reported cases since 1982, mechanisms include auto-PEEP and delayed drug effects.
Lazertinib
Lazertinib (YH25448; Leclaza, Lazcluze) is an oral, brain-penetrant third-generation EGFR tyrosine kinase inhibitor for NSCLC, approved in South Korea in 2021 and, with amivantamab, in the US in 2024.
Laziness
Laziness, also called sloth or idleness, is the disinclination to work or expend effort. Not a psychiatric diagnosis; modern research explains it via motivation quality, effort-based decision making, depression, and apathy.
LB2102 (DLL3 CAR-T)
LB2102 (DJI-136) is Legend Biotech's dnTGFBR2-armored, DLL3-targeted autologous CAR-T therapy for ES-SCLC and LCNEC, licensed to Novartis in 2023 for $100M upfront plus up to $1.01B milestones; phase 1 NCT05680922 showed no DLTs and ORR 18%.
LBL-051
LBL-051: first-in-class CD19×BCMA×CD3 trispecific T-cell engager from Nanjing Leads Biolabs' LeadsBody platform, licensed to Aditum Bio spinout Oblenio Bio for autoimmune B-cell depletion; Phase 1a dosing in Europe since August 2026.