25,729 articles
Obecabtagene autoleucel
Obecabtagene autoleucel (obe-cel, AUCATZYL, AUTO1) is an autologous CD19-directed CAR T-cell therapy by Autolus, FDA-approved November 8, 2024 for adults with relapsed/refractory B-cell precursor ALL; FELIX trial showed 78% remission with low severe CRS and ICANS.
Obefazimod
Obefazimod (ABX464, SPL-464) is Abivax's oral quinoline small molecule that binds the cap-binding complex to upregulate miR-124; developed first for HIV, now in Phase 3 for ulcerative colitis.
Obeldicks study
Obeldicks: German one-year outpatient lifestyle intervention for obese children and adolescents (Datteln, Witten/Herdecke), combining nutrition, exercise, and behavior therapy; 79% success, sustained 4-year weight loss, with Obeldicks Light and Mini variants.
OBESE-DKD trial
OBESE-DKD (NCT04626323), Randomized Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease: open-label randomized trial randomizing 60 patients with type 2 diabetes, proteinuria, obesity, and CKD stage 3 to Roux-en-Y gastric bypass versus best medical treatment.
Obesity
Obesity, a chronic disease of excess body fat diagnosed in adults as BMI ≥ 30 kg/m², affected 1.1 billion people in 2024; the 2025 Lancet Commission split it into clinical and preclinical categories beyond BMI.
Obesity hypoventilation syndrome
Obesity hypoventilation syndrome, also called Pickwickian syndrome, is obesity (BMI ≥30) with awake hypercapnia (PaCO2 ≥45 mmHg) and sleep-disordered breathing; about 90% of patients have OSA, and CPAP or NIV plus weight loss are the main treatments.
Obesity in children or adolescents
Pediatric obesity, excessive fat accumulation in children and adolescents defined by WHO growth references; 170 million affected aged 5-19 in 2024; treated with behavioral intervention, GLP-1 drugs, bariatric surgery.
Obesity in the United States
Obesity in the United States: adults with BMI 30+. NHANES measured prevalence 40.3% (2021–2023), up from 13.4% in 1960–1962; severe obesity 9.7%; GLP-1 drug use rising rapidly.
Obesity Management
Obesity management, also called weight management, is the integrated professional screening, evaluation, and treatment of obesity as a chronic disease, using lifestyle intervention, GLP-1 pharmacotherapy, and bariatric surgery within multidisciplinary care.
Obeticholic acid
Obeticholic acid (Ocaliva, 6α-ethyl-chenodeoxycholic acid) is a semisynthetic FXR agonist approved in 2016 for primary biliary cholangitis, later withdrawn in the EU (2024) and US (2025).
Obexelimab
Obexelimab is a monoclonal antibody targeting CD19 and FcγRIIB that inhibits B-cell signaling without depleting B cells, developed for autoimmune diseases including IgG4-related disease.
Obiltoxaximab
Obiltoxaximab (Anthim) is a monoclonal antibody against Bacillus anthracis protective antigen, FDA-approved in 2016 for treating and preventing inhalational anthrax, dosed 16 mg/kg IV, and stockpiled in the US Strategic National Stockpile.
Obinutuzumab
Obinutuzumab (Gazyva, GA101) is a glycoengineered type II anti-CD20 humanized IgG1 monoclonal antibody for CLL, follicular lymphoma, lupus nephritis, and idiopathic nephrotic syndrome, with enhanced ADCC and direct cell death versus rituximab.
Obinutuzumab/venetoclax regimen
The obinutuzumab/venetoclax regimen is a fixed-duration combination of the antibody obinutuzumab and the oral BCL-2 inhibitor venetoclax, used to treat previously untreated chronic lymphocytic leukemia.
Objective structured clinical examination
The objective structured clinical examination (OSCE) is a performance-based medical assessment where examinees rotate through timed stations, scored on clinical tasks, devised in Scotland in the 1970s.
Oblimersen sodium
Oblimersen sodium (G3139, augmerosen, Genasense) is a first-generation phosphorothioate antisense 18-mer against BCL-2 mRNA, tested in phase 3 cancer trials but refused EMA approval.
ObOd study
ObOd (Obesity and Oral Diseases in Adult Patients, NCT04602572) is a University of Bergen prospective cohort study of 400 obese adults at Haukeland University Hospital, tracking periodontal and caries outcomes over 18 months after non-surgical or bariatric weight-loss treatment.
Obscure gastrointestinal bleeding
Obscure gastrointestinal bleeding (OGIB) is bleeding from the digestive tract with no source found after negative endoscopy; it may be visible or hidden, such as iron-deficiency anemia.
ObservatoireEI study
ObservatoireEI (Observatoire EI, NCT03272724) is the French National Observatory on Infective Endocarditis, a prospective multicentre open cohort registry run from Nancy, enrolling adults with definite or possible IE since 2008.
Obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD), a mental disorder of recurring obsessions and compulsions, lifetime prevalence 1–3%, classified in Obsessive-Compulsive and Related Disorders in DSM-5 and ICD-11, treated with ERP and SSRIs.
Obsessive–compulsive personality disorder
Obsessive–compulsive personality disorder (OCPD), also called anankastic personality disorder, is a Cluster C personality disorder marked by perfectionism, orderliness, and control; distinct from OCD, prevalence about 2–8%, treated with psychotherapy and SRIs.
Obstetric embolism
Obstetric embolism is the blockage of a maternal blood vessel by a clot, air, fat, amniotic fluid, or infected material during pregnancy, childbirth, or the puerperium.
Obstetric fistula
Obstetric fistula, or vesicovaginal and rectovaginal fistula from obstructed labour, is a childbirth tear causing incontinence; 50,000-100,000 new cases yearly, treatable by surgery, preventable with obstetric care.
Obstetric laceration of cervix
Obstetric laceration of cervix (cervical tear from childbirth; ICD-11 JB0A.3, ICD-10 O71.3): a tear of the cervix during labor or delivery, causing postpartum hemorrhage; risk factors include forceps delivery, cerclage, nulliparity, and induction.
Obstetric Surgical Procedures
Obstetric surgical procedures are operations performed on a pregnant woman for conditions of pregnancy, labor, or the puerperium, ranging from cesarean section, the most frequent major abdominal surgery worldwide, to cervical cerclage.
Obstetric ultrasonography
Obstetric ultrasonography (prenatal ultrasound, fetal sonography) images the fetus and uterus with sound waves, not radiation. Key uses: CRL dating at 8–14 weeks, biometry (BPD, HC, AC, FL), anomaly screening, Doppler, 3D/4D imaging.
Obstetrical Analgesia
Obstetrical analgesia (obstetric analgesia) is pain relief without loss of consciousness during labor, delivery, or the postpartum period. Main methods: epidural and combined spinal-epidural blocks, parenteral opioids, nitrous oxide; epidural gives the strongest pain relief with trade-offs in hypotension, fever, and assisted birth.
Obstetrical and Gynecological Diagnostic Techniques
Obstetrical and gynecological diagnostic techniques (MeSH D003944) are methods for diagnosing pregnancy, labor, puerperium, and female genital diseases, spanning ultrasound, NIPT, amniocentesis, CVS, hysteroscopy, and colposcopy.
Obstetrical Extraction
Obstetrical extraction, or operative vaginal delivery, is birth assisted by obstetric forceps or a vacuum extractor (ventouse) during the second stage of labor; rates run 5-20% in high-income countries and are declining.
Obstetrical Forceps
Obstetrical forceps: two-bladed metal instrument for assisted vaginal birth, invented by Peter Chamberlen the Elder, kept secret a century, refined by Smellie; now used in under 1% of US vaginal births.