25,729 articles
Oculoskeletodental syndrome
Oculoskeletodental syndrome (OCSKD, OMIM 618440) is an extremely rare autosomal recessive ciliopathy caused by PIK3C2A loss-of-function variants, causing congenital cataract, glaucoma, skeletal and dental anomalies, developmental delay, and stroke.
Oculotrichoanal syndrome
Oculotrichoanal syndrome, also called Manitoba oculotrichoanal (MOTA) or Marles syndrome, is a rare autosomal recessive FREM1 disorder with hypertelorism, eyelid coloboma, aberrant hairline, and anal anomalies, concentrated in a northern Manitoba Ojibway-Cree community.
Odanacatib
Odanacatib (MK-0822) was an investigational oral, once-weekly cathepsin K inhibitor Merck developed for osteoporosis and abandoned in September 2016 after a trial showed increased stroke risk.
Odense University Hospital
Odense University Hospital, also known as Odense Universitetshospital (OUH), is one of Denmark's four university hospitals, in Odense, owned by the Region of Southern Denmark and partnered with the University of Southern Denmark.
Odesivimab
Odesivimab (REGN3471) is a non-neutralizing human IgG1 antibody against Ebola virus glycoprotein, one of three components of Inmazeb (REGN-EB3), FDA-approved October 14, 2020 for Zaire ebolavirus infection; it kills infected cells via FcγRIIIa effector signaling and also binds soluble glycoprotein.
Odevixibat
Odevixibat (Bylvay) is an oral ileal bile acid transporter inhibitor by Albireo/Ipsen treating cholestatic pruritus in PFIC (approved EU/US 2021) and Alagille syndrome (US 2023), acting locally in the gut.
Odonto-onycho-dermal dysplasia
Odonto-onycho-dermal dysplasia (OODD, OMIM 257980) is a rare autosomal recessive WNT10A ectodermal dysplasia with severe tooth agenesis, cone-shaped teeth, nail dystrophy, palmoplantar hyperkeratosis, and variable sweating changes.
Odontochondrodysplasia
Odontochondrodysplasia (ODCD, Goldblatt syndrome, OMIM 184260) is a rare autosomal recessive skeletal dysplasia with dentinogenesis imperfecta, short stature, joint laxity, and platyspondyly, caused by hypomorphic TRIP11 or MIA3 variants.
Odontogenesis imperfecta
Odontogenesis imperfecta (ODI) is a hereditary tooth-structure disturbance, a generalized genetic defect of enamel and dentine formation; also a former MeSH heading (1965-93) for odontodysplasia and ICD-11 code LA30.9.
Odontoidectomy
Odontoidectomy is a neurosurgical procedure that removes the odontoid process of the second cervical vertebra to relieve compression of the brainstem and upper spinal cord.
Odontology
Odontology (ISSN 1618-1247) is a peer-reviewed English dentistry and craniofacial research journal, official journal of the Society of the Nippon Dental University, published by Springer since 2001 as successor to Shigaku; MEDLINE-indexed, 2025 impact factor 2.6.
Odontometry
Odontometry is the measurement of tooth characteristics (MeSH D009811), covering mesiodistal and buccolingual crown dimensions used in orthodontics, endodontic working-length determination, and forensic estimation of sex, age, and population affinity.
Odronextamab
Odronextamab (REGN1979, Ordspono) is Regeneron's fully human IgG4 CD20 x CD3 bispecific antibody for relapsed/refractory follicular lymphoma and DLBCL; EU conditional approval August 2024, FDA complete response letters.
Odulimomab
Odulimomab (anti-LFA1, antibody 25.3) is a murine IgG1 monoclonal antibody against human CD11a, the LFA-1 alpha chain; the first LFA-1/ICAM-1 antibody tested clinically, in bone marrow and kidney transplant induction.
Oedema of eyelid
Oedema of eyelid (eyelid edema, ICD-11 NA06.02) is fluid-driven eyelid swelling from allergic, infectious, inflammatory, drug, traumatic, or systemic causes; orbital cellulitis is the key dangerous differential.
Oedema of larynx
Oedema of larynx (laryngeal edema, ICD-11 CA0H.3, ICD-10 J38.4) is fluid accumulation in laryngeal tissue from anaphylaxis, angioedema, infection, intubation injury, or radiotherapy, causing hoarseness and potentially fatal airway obstruction.
Oedema of legs
Oedema of legs (lower extremity oedema, ICD-11 MG29.01) is excess interstitial fluid causing leg swelling; causes include heart, kidney, liver failure, venous disease, DVT, and drugs such as amlodipine.
Oesophageal erosion
Oesophageal erosion (esophageal erosion, ICD-11 DA25.0) is a shallow mucosal breach of the oesophagus not extending through the muscularis mucosa, usually caused by acid reflux, diagnosed by endoscopy, and treated with proton pump inhibitors.
Oesophageal fistula without atresia
Oesophageal fistula without atresia, or H-type tracheoesophageal fistula (Gross type E), is a rare congenital trachea-oesophagus connection with a patent oesophagus, occurring in 1 in 50,000–80,000 births, diagnosed by bronchoscopy and cured by surgical division.
Oesophageal haemorrhage
Oesophageal haemorrhage (食道出血), ICD-11 code ME24.A2, is bleeding from the oesophagus classified under upper gastrointestinal bleeding; causes include varices, oesophagitis, Mallory-Weiss tears, and oesophageal haematoma.
Oesophageal obstruction
Oesophageal obstruction (ICD-11 DA20.0, ICD-10 K22.2): partial or complete blockage of the esophagus from intrinsic causes (tumors, rings, webs, strictures) or extrinsic compression, presenting as dysphagia and treated by cause-directed endoscopy.
Oesophageal ulcer
An oesophageal ulcer, spelled esophageal ulcer in American English, is a mucosal break in the oesophagus extending into deeper wall layers, usually caused by reflux or drugs.
Oesophageal varices with bleeding
Oesophageal varices with bleeding (ICD-11 DA26.00) is rupture of dilated portosystemic collateral veins in the lower oesophagus due to portal hypertension, treated with vasoactive drugs, band ligation, and TIPS; six-week mortality is 10-20%.
Oesophageal varices without bleeding
Oesophageal varices without bleeding, also called unruptured esophageal varices, are dilated lower-esophageal collateral veins from portal hypertension, present in about 60% of cirrhosis patients, graded small or large, and managed with beta-blockers or band ligation.
Oesophageal web
Oesophageal web (esophageal web): thin mucosal membrane across the upper esophagus, often with iron-deficiency anemia or Plummer-Vinson syndrome; causes dysphagia, diagnosed by barium swallow, treated by dilation.
Oesophagitis
Oesophagitis (esophagitis), inflammation of the oesophagus, ICD-11 DA24. Causes include reflux, infection, pills, allergies, radiation; EoE defined by ≥15 eosinophils/hpf.
Oesophagostomiasis
Oesophagostomiasis, or nodular worm infection (ICD-11 1F69), is human infection with Oesophagostum nematodes, mainly Oesophagostomum bifurcum, endemic in northern Togo and Ghana, causing nodular abdominal disease and controlled by albendazole mass treatment.
OFA VS OBA1 study
OFA VS OBA1 (NCT07075302) is a retrospective observational cohort study at Hospital HM Nou Delfos, Barcelona, comparing opioid-free versus opioid-based anesthesia in 70 bariatric surgery patients, with 48-hour morphine consumption as the primary outcome.
OFA-MG study
OFA-MG (NCT07077031) is a retrospective observational study at Hospital HM Nou Delfos, Barcelona, comparing magnesium sulfate bolus 40 mg/kg versus bolus 50 mg/kg plus 15 mg/kg/h infusion in opioid-free anesthesia for bariatric surgery; infusion reduced 48-hour morphine use.
Ofatumumab
Ofatumumab (Arzerra, Kesimpta) is a fully human anti-CD20 IgG1κ monoclonal antibody, FDA-approved in 2009 for CLL and later as subcutaneous Kesimpta for relapsing multiple sclerosis; EU Arzerra authorization withdrawn in 2019.