edgepedia

DNA replication, repair, and metabolism

49 articles

Neil Osheroff

Neil Osheroff is an American biochemist at Vanderbilt University School of Medicine known for research on type II topoisomerases and the anticancer and antibacterial drugs targeting them.

Nicholas R. Cozzarelli

Nicholas R. Cozzarelli (1938–2006) was an American biochemist at UC Berkeley and a leading authority on DNA topology who served as editor-in-chief of PNAS from 1995 until his death.

Nicolas Thomä

Nicolas Thomä is a German structural biologist, professor of cancer research at EPFL since 2023, known for structural work on thalidomide and molecular glue degraders.

Paul Modrich

Paul Modrich (born 1946) is an American biochemist at Duke University who elucidated DNA mismatch repair, the pathway correcting replication errors, and shared the 2015 Nobel Prize in Chemistry.

Paul W. K. Rothemund

Paul W. K. Rothemund, also known as Paul Rothemund, is an American researcher at Caltech who invented scaffolded DNA origami, described in Nature in 2006.

Peter von Hippel

Peter H. von Hippel is an American molecular biologist and biophysical chemist, emeritus professor at the University of Oregon, known for kinetic studies of transcription and DNA replication.

R. Scott Williams

R. Scott Williams (Robert S. Williams) is a structural biologist who leads the Genome Integrity and Structural Biology Laboratory at NIEHS, studying how cells recognize and repair DNA strand breaks.

Robert A. Bambara

Robert A. Bambara is an American biochemist and professor emeritus at the University of Rochester School of Medicine, known for work on Okazaki fragment maturation and HIV reverse transcription.

Rosalind Franklin

Rosalind Elsie Franklin (1920–1958), British X-ray crystallographer; her Photo 51 and MRC data underpinned the 1953 DNA double helix model; also coal, carbon, and virus research.

Smita S. Patel

Smita S. Patel is an American biochemist and Distinguished Professor at Rutgers Robert Wood Johnson Medical School, known for quantitative studies of DNA helicases and mitochondrial replication enzymes.

Stephen Zamenhof

Stephen Zamenhof (1911–1998) was a Polish-born American biochemist, nephew of the creator of Esperanto, who worked on nucleic acid chemistry and chemical mutagenesis at Columbia and UCLA.

T.H. Tahirov

T.H. Tahirov, also known as Tahir H. Tahirov, is a structural biologist at the University of Nebraska Medical Center known for crystal structures of DNA replication and transcription complexes.

Thomas A. Kunkel

Thomas A. Kunkel is an American biochemist at NIEHS known for work on DNA replication fidelity, elected to the National Academy of Sciences in 2024.

Timothy M. Lohman

Timothy M. Lohman is an American biochemist at Washington University School of Medicine known for quantitative work on DNA helicases and the E. coli SSB protein.

Tomas Lindahl

Tomas Lindahl is a Swedish-born biochemist in the UK who showed DNA is continually damaged and repaired, winning a third of the 2015 Nobel Prize in Chemistry.

Ulrich Hübscher

Ulrich Hübscher is a Swiss molecular biologist and biochemist at the University of Zurich known for his work on eukaryotic DNA polymerases and DNA repair.

Walter Verly

Walter Verly (1923–2025) was a Belgian biochemist who discovered an E. coli endonuclease specific for apurinic sites in DNA, cited in the 2015 Nobel Prize background.

Wei Yang (molecular biologist)

Wei Yang (杨薇) is a Chinese-born American structural biologist at NIH known for crystal structures of DNA repair proteins, elected to the National Academy of Sciences in 2013.

William L. Carrier

William Louis Carrier (1929–2016) was an American biochemist at Oak Ridge National Laboratory who, with Richard Setlow, showed in 1964 that UV-damaged DNA is repaired by excision, founding nucleotide excision repair.