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Nucleic acids, RNA, and chromatin

164 articles

Jean Brachet

Jean Brachet (1909–1988) was a Belgian biochemist and embryologist at the Université Libre de Bruxelles who showed that RNA is essential to protein synthesis, making him a founder of molecular biology.

Jean Thomas (Welsh biochemist)

Jean Olwen Thomas is a British biochemist whose work on histone association underpinned the nucleosome model of chromatin; she is a Fellow of the Royal Society.

Jean‐Louis Mergny

Jean-Louis Mergny (born 1966 in Nantes) is a French biophysicist and Inserm research director at École Polytechnique known for work on G-quadruplex DNA and the G4Hunter algorithm.

Jeffrey S. Kieft

Jeffrey S. Kieft is an RNA structural biologist and virologist known for work on viral IRES RNAs, and Executive Director of the New York Structural Biology Center since 2023.

Jerard Hurwitz

Jerard Hurwitz (1928–2019) was an American biochemist at Memorial Sloan Kettering Cancer Center who co-discovered DNA-dependent RNA polymerase in 1960 and polynucleotide kinase, DNA ligase, and RNA ligase.

Jeremy M Berg

Jeremy M. Berg is an American biochemist known for predicting the structure of zinc finger proteins and directing NIGMS at the NIH from 2003 to 2011.

Jerome Vinograd

Jerome Vinograd (1913–1976) was an American biophysical chemist at Caltech, called by The New York Times one of the foremost DNA researchers, known for density gradient ultracentrifugation and closed circular DNA.

Jerry L. Workman

Jerry L. Workman is an American biochemist at the Stowers Institute for Medical Research who pioneered the study of chromatin in transcription regulation and discovered the SAGA complex.

Jikui Song

Jikui Song is a structural biologist whose laboratory determines the structures of DNA methyltransferases, explaining how DNA methylation patterns are established and maintained in mammals.

Jirō Kondō

Jirō Kondō (近藤 次郎; Jiro Kondo) is a Japanese structural molecular biologist and professor at Sophia University in Tokyo, known for X-ray crystal structures of DNA and RNA, including a metallo-DNA nanowire.

Johannes C. Walter

Johannes C. Walter, also known as Johannes Walter, is an American biochemist and HHMI investigator at Harvard Medical School who studies how vertebrate cells replicate and repair DNA.

John A. Tainer

John A. Tainer is an American structural biologist who determines atomic structures of DNA repair proteins, work linking mutations in those machines to cancer, at MD Anderson Cancer Center.

John E. Hearst

John E. Hearst (1935–2022) was an American chemist at UC Berkeley and Lawrence Berkeley National Laboratory known for psoralen photochemistry probing nucleic acid structure and for co-founding Cerus Corporation.

John N. Vournakis

John N. Vournakis (1939–2018) was an American physical biochemist who studied messenger RNA at MIT, Harvard, and Syracuse, helped clone the first mammalian gene, and co-founded biotech companies.

Jonathan B. Chaires

Jonathan B. Chaires, also published as Jonathan Chaires, is an American biophysical chemist at the University of Louisville known for research on nucleic acids, G-quadruplexes, and drug-DNA interactions.

Juli Feigon

Juli Feigon is an American structural biologist who studies nucleic acid structures and is Distinguished Professor of Biochemistry at UCLA, known for NMR and cryo-EM structures of telomerase.

K. E. van Holde

K. E. van Holde, or Kensal Edward van Holde, was an American biochemist at Oregon State University best known for describing the nucleosome core particle and chromatin structure.

Karolin Luger

Karolin Luger is an Austrian-born biochemist and structural biologist at the University of Colorado Boulder, best known as lead author of the 1997 crystal structure of the nucleosome.

Katalin Karikó

Katalin Karikó (Karikó Katalin), Hungarian-American biochemist born 1955 in Szolnok; with Drew Weissman showed nucleoside-modified mRNA evades immune detection, enabling BioNTech/Pfizer and Moderna COVID-19 vaccines and the 2023 Nobel Prize in Physiology or Medicine.

Keith R. Fox

Keith R. Fox is a British biochemist who spent his career at the University of Southampton, studying DNA sequence recognition, triple helices, and G-quadruplex structures.

Keqiong Ye

Keqiong Ye (叶克穷) is a Chinese structural biologist who has led a research group at the Institute of Biophysics, Chinese Academy of Sciences, since 2014, known for crystal structures of box C/D and H/ACA snoRNPs.

Kevin D. Corbett

Kevin D. Corbett is a structural biologist and professor of cellular and molecular medicine at UC San Diego since 2011, known for his work on meiotic chromosomes and bacterial anti-phage defenses.

Kozo Tomita

Kozo Tomita (富田 耕造) is a Japanese structural biologist and molecular biologist who studies RNA, and has been professor of RNA biology at the University of Tokyo since 2016, known for work on the CCA-adding enzyme.

Leon A. Heppel

Leon A. Heppel (1912–2010) was an American biochemist who pioneered RNA enzymology and developed the osmotic shock method for releasing enzymes from bacteria, working at NIH and Cornell.

M Rhyan Puno

M Rhyan Puno (Marc Rhyan Anthony Puno) is an American structural biologist known for 2018 structures of the RNA exosome and the discovery that YTHDC2 is essential for meiosis.

M.C. Wahl

Markus C. Wahl is a German structural biochemist, professor at Freie Universität Berlin since 2009, known for his work on the spliceosome and the Mg²⁺-independent kinase CASK.

Mahlon Hoagland

Mahlon Hoagland (1921–2009) was an American biochemist who co-discovered amino acid activation and transfer RNA with Paul Zamecnik, and led the Worcester Foundation from 1970 to 1985.

Malcolm F. White

Malcolm F. White is a biochemist and Professor of Biochemistry at the University of St Andrews, known for research on CRISPR antiviral defense and DNA repair.

Maria A. Schumacher

Maria A. Schumacher is a structural biologist who determines atomic structures of protein–DNA and protein–RNA regulatory complexes, especially in microbial pathogenesis, and is a Distinguished Professor of Biochemistry at Duke University.

Maria Spies

Maria Spies is a biophysicist and professor of biochemistry and molecular biology at the University of Iowa, known for single-molecule dissection of DNA repair machines and for her HHMI Early Career Scientist Award.