72,234 articles
Six-cysteine peptide SCIFF
SCIFF (Six Cysteines in Forty-Five Residues) peptides are cysteine-rich RiPP natural products from clostridia, modified by radical SAM enzymes into ranthipeptide thioether crosslinks and involved in quorum sensing.
Six-minute walk test
The six-minute walk test (6MWT) is a self-paced clinical exercise test measuring the distance walked in six minutes, widely used in COPD and pulmonary arterial hypertension.
SIX1
SIX1 (SIX Homeobox 1, sine oculis homeobox homolog 1) is a chromosome 14q23.1 homeobox transcription factor gene essential for embryonic organ development, mutated in BOR syndrome and DFNA23 deafness, and re-expressed as a poor-prognosis driver in breast, colorectal, and other cancers.
Sixth nerve palsy
Sixth nerve palsy (abducens palsy, CN VI palsy): paralysis of the sixth cranial nerve causing esotropia and horizontal double vision worse at distance and toward the affected side; usually microvascular, about 80% recover.
Siyu Zhang
Siyu Zhang is a Chinese systems neuroscientist who has been Principal Investigator at Shanghai Jiao Tong University School of Medicine since 2016, studying top-down attention and basal forebrain sleep-wake circuits.
SJ02
SJ02, sold as Slonva (晟诺娃), is a long-acting follicle-stimulating hormone drug approved in China in August 2025, where one injection replaces the first seven days of daily FSH injections in fertility treatment.
SJL/J
SJL/J (Swiss Jim Lambert) is an inbred laboratory mouse strain from Jackson Laboratory, H-2s haplotype, used for relapsing-remitting EAE multiple sclerosis research, reticulum cell sarcomas, and radioresistance.
SJLIFE study
SJLIFE (St. Jude Lifetime Cohort Study), NCT00760656, is a longitudinal cohort of childhood cancer survivors treated at St. Jude since 1962, with 3–4-day clinical assessments every 5 years, genomic sequencing, and findings on late effects and subsequent neoplasms.
SJNB-10
SJNB-10 (SJ-NB-10, NB10, NB90-9; CVCL_1441) is a human neuroblastoma cancer cell line from a 2-year-old male with an adrenal primary and liver metastasis, characterized by homozygous NF1 deletion, loss of neurofibromin, and retinoic acid resistance.
SJNB-12
SJNB-12 is a human neuroblastoma cell line derived from a bone marrow metastasis in a female infant sampled at 10 months of age, with high BCL-2 expression.
Sjoerd H. van der Burg
Sjoerd H. van der Burg is a Dutch immunologist, full professor of immunotherapy of solid tumors at Leiden University Medical Center since 2010, studying T cells and cancer.
Sjoerd Rodenhuis
Sjoerd Rodenhuis is a Dutch clinical oncologist, professor at the University of Amsterdam from 1996 to 2016, known for K-ras oncogene work in lung cancer and Dutch high-dose breast cancer trials.
Sjögren syndrome
Sjögren syndrome (Sjögren's disease), chronic autoimmune disorder attacking salivary and lacrimal glands, causing dry mouth and dry eyes; affects 1–4 million Americans, mostly women over 50, with elevated non-Hodgkin lymphoma risk.
Sjögren-Larsson syndrome
Sjögren-Larsson syndrome (SLS, OMIM #270200): autosomal recessive neurocutaneous disorder from ALDH3A2/FALDH deficiency, causing congenital ichthyosis, spastic diplegia, intellectual disability, and diagnostic retinal glistening white dots; distinct from Sjögren's disease.
Sjors Scheres
Sjors Scheres is a Dutch structural biologist and group leader at the MRC Laboratory of Molecular Biology in Cambridge, known for RELION, the most used cryo-EM structure determination program.
SJSA-1
SJSA-1 (OsA-CL, OSA; ATCC CRL-2098, RRID CVCL_1697) is a human osteosarcoma cell line established in 1982 from a 19-year-old male's femur tumor, distinguished by ~20-fold MDM2 amplification with wild-type TP53.
Sjur Olsnes
Sjur Olsnes (1939–2014) was a Norwegian biochemist and cancer researcher at the University of Oslo known for defining how the toxic lectins abrin and ricin kill cells.
SK-BR-3
SK-BR-3 (SKBR3), ATCC HTB-30, Cellosaurus CVCL_0033: human breast adenocarcinoma cell line established 1970 from a pleural effusion; HER2-positive, ER/PR-negative standard model for HER2-targeted therapy research.
SK-ES-1
SK-ES-1 (SK-ES-01, CVCL_0627) is a human Ewing sarcoma cell line established in 1971 from an 18-year-old male's bone biopsy at Memorial Sloan Kettering; it carries an EWSR1-FLI1 type 2 fusion and TP53 C176F.
SK-HEP-1
SK-HEP-1 (CVCL_0525, ATCC HTB-52) is a human cancer cell line established in 1971 from ascites of a 52-year-old man with liver adenocarcinoma; long used as a hepatocellular carcinoma model but now shown to be of endothelial origin.
SK-LU-1
SK-LU-1 (SKLU01, ATCC HTB-57, Cellosaurus CVCL_0629) is a human lung adenocarcinoma cell line established in 1969; KRAS G12D, CDKN2A-deleted, telomerase-negative and ALT-positive, non-tumorigenic in immunocompromised mice.
SK-MEL-2
SK-MEL-2 (CVCL_0069, ATCC HTB-68) is a human melanoma cell line from a 60-year-old male, established at Memorial Sloan Kettering; NRAS Q61R-mutant, TP53 G245S, NCI-60 panel member.
SK-MEL-23
SK-MEL-23 (CVCL_6027, SKMEL23) is a highly pigmented human cutaneous melanoma cell line from Memorial Sloan Kettering, established from a metastatic lymph node; PTEN-deleted, NRAS wild type, BRAF fusion, used in pigmentation, drug response, and immunotherapy research.
SK-MEL-28
SK-MEL-28 (ATCC HTB-72) is a human melanoma cell line established in 1975 from a 51-year-old male, homozygous BRAF V600E with wildtype NRAS, tumorigenic in nude mice, and a standard melanoma research model alongside A-375.
SK-MEL-5
SK-MEL-5 (CVCL_0527, ATCC HTB-70) is a human melanoma cell line established in 1974 from a metastatic axillary lymph node of a 24-year-old woman, carrying BRAF V600E and a CDKN2A deletion, used in NCI-60 drug screening and immunology research.
SK-MES-1
SK-MES-1 (SK MES 1, CVCL_0630, ATCC HTB-58) is a human lung squamous cell carcinoma cell line established in 1970 from a pleural effusion of a 65-year-old man at Memorial Sloan Kettering by Old and Trempe; epithelial, adherent, TP53-mutant.
SK-N-AS
SK-N-AS (ATCC CRL-2137, Cellosaurus CVCL_1700) is a human neuroblastoma cell line established in 1981 from a bone marrow metastasis in a 6-year-old girl; non-MYCN-amplified, IGF-II-producing, S-type, tumorigenic in nude mice.
SK-N-BE(2)
SK-N-BE(2) (CVCL_0528, ATCC CRL-2271) is a human neuroblastoma cell line established in 1972 from a bone marrow metastasis in a male child; MYCN-amplified, 1p-loss, 17q-gain, with sublines SK-N-BE(2)-C and BE(2)-M17.
SK-N-BE(2)-C
SK-N-BE(2)-C (BE2C, CVCL_0529, ATCC CRL-2268) is a clonal subline of the SK-N-BE(2) human neuroblastoma cell line, MYCN-amplified with a TP53 C135F mutation, I-type phenotype, derived from a 1972 bone marrow metastasis.
SK-N-MC
SK-N-MC (ATCC HTB-10, CVCL_0530) is a human cell line established in 1971 from a supra-orbital metastasis of an Askin tumor; long mislabeled neuroblastoma, it is an Ewing sarcoma line carrying EWS-FLI1.