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Life and health

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Hanseniaspora

Hanseniaspora (anamorph Kloeckera) is a genus of apiculate, bipolarly budding ascomycete yeasts in Saccharomycodaceae, named in 1912; H. uvarum dominates early wine fermentation, and species show genome reduction and gene loss.

Hansoh CDH17 antibody-drug conjugate (licensed to Roche)

HS-20110 is Hansoh Pharma's CDH17-targeting antibody-drug conjugate with a topoisomerase inhibitor payload, in Phase I trials for colorectal cancer; Roche licensed worldwide rights (excluding Greater China) for US$80 million upfront plus up to US$1.45 billion in milestones.

Hantavirus infection

Hantavirus infection, or hantavirus disease, is rodent-borne illness from Hantaviridae viruses, causing HPS/HCPS in the Americas and HFRS in Europe and Asia; Andes virus alone spreads person to person.

Hantavirus pulmonary syndrome

Hantavirus pulmonary syndrome (HPS, also HCPS) is a severe rodent-borne respiratory disease of the Americas caused by New World hantaviruses such as Sin Nombre and Andes virus, first recognized in the 1993 Four Corners outbreak, with roughly 38% fatality and no specific treatment.

Hao WU

Hao Wu (吴昊) is an American epigeneticist and Associate Professor of Genetics at the University of Pennsylvania, known for mapping how TET enzymes reshape DNA methylation.

Hao Yu

Hao Yu, also known as Yu Hao (俞皓), is a Singapore-based plant biologist at the National University of Singapore known for work on flowering control in plants.

Hao Zhu

Hao Zhu is an American physician-scientist and medical oncologist who studies liver regeneration and liver cancer at UT Southwestern, where he directs the Tissue Regeneration Program.

Hao-Fountain syndrome

Hao-Fountain syndrome (HAFOUS, OMIM 616863), also called USP7-related neurodevelopmental disorder, is a rare autosomal dominant disorder caused by USP7 variants or 16p13.2 microdeletion, marked by developmental delay, speech delay, autism, hypotonia, and dysmorphic features.

Haojie Huang

Haojie Huang (黄浩杰) is a molecular biologist who researches prostate cancer, transcription factors, and therapy resistance. He is currently a Qiushi Chair Professor at Zhejiang University.

Haolong

Haolong (豪龙), type species Haolong dongi, is a 2026-named basal hadrosauroid iguanodontian dinosaur from the Early Cretaceous of Liaoning, China, the first non-avian dinosaur found with cellular-level preserved hollow skin spikes; the name also denotes a Tiangong cargo spaceplane.

Haoxing Xu

Haoxing Xu is a cell physiologist known for establishing the lysosome as a signaling organelle, pioneering the whole-lysosome patch clamp, identifying TRPML channels, and receiving a 2009 PECASE award.

Hapalemur

Hapalemur, the bamboo or gentle lemurs, is a Madagascar-endemic lemurid genus including H. griseus, H. aureus, H. meridionalis, and H. alaotrensis; bamboo-feeding, cyanide-tolerant vertical clingers and leapers, with the greater bamboo lemur often placed in Prolemur.

Haphephobia

Haphephobia, also called aphephobia or chiraptophobia, is a rare specific phobia of being touched, diagnosed under DSM-5 and ICD-11 (6B03), treated mainly with exposure therapy.

Haploceras

Haploceras is an extinct genus of haploceratid ammonoid cephalopods, type genus of Haploceratidae, type species H. elimatum, ranging from the lower Tithonian to lower Berriasian and showing sexual dimorphism.

Haplogroup

A haplogroup, short for haplotype group, is a genetic lineage defined by shared mutations on a branch of a DNA tree, tracing maternal mtDNA or paternal Y-chromosome ancestry.

Haplogroup A0a1 (Y-DNA)

Haplogroup A0a1 (Y-DNA), also written A0-A1, is a deep subclade of paternal haplogroup A under A0a/A0, estimated ~180,000 years old, associated with West-Central Africa, with one known subclade A0a1a and shallow sampling.

Haplogroup A0a2 (Y-DNA)

Haplogroup A0a2 is a deep subclade of haplogroup A0a in the human Y-chromosome tree, estimated at about 170,000 years old and carried today at low levels mainly in West-Central African forager groups.

Haplogroup A1b1 (Y-DNA)

Haplogroup A1b1 (Y-DNA), also written A1b1-L419/PF712, is a deep early-diverging African paternal lineage under A1b-P108, sister to megahaplogroup BT (split marked by M42/M94), with subclades A1b1a-M14 and A1b1b-M32, split estimated at about 143 kya.

Haplogroup B (Y-DNA)

Haplogroup B (Y-DNA), defined by SNPs M60 and M181, also called B-M60, is an aboriginal African paternal lineage, TMRCA about 110 kya, concentrated in Pygmy and Khoisan forager groups, with main subclades B1, B2a-M150, B2b, and B3.

Haplogroup B2a2 (Y-DNA)

Haplogroup B2a2, a subclade of Y-DNA haplogroup B2a (B-M150), a sub-Saharan African paternal lineage; star-like expansion, highest frequencies in Botswana and Cameroon, dating to about 40 kya, predating the Bantu expansion.

Haplogroup B2b1 (Y-DNA)

Haplogroup B2b1 (Y-DNA), also written B-M192, is a paternal lineage under B-M112 defined by SNPs M192 and 50f2(P), found mainly among Khoe-San men, with branches among Hadza, Sandawe, and Baka; TMRCA estimates around 43,000-62,000 years.

Haplogroup B2b2 (Y-DNA)

Haplogroup B2b2 (Y-DNA), also B-M115, is an African paternal subclade of B2b (M112) within haplogroup B, associated with Central African Pygmy and Khoisan hunter-gatherer populations; distinct from the unrelated Native American mtDNA haplogroup B2b2.

Haplogroup C1a1 (Y-DNA)

Haplogroup C1a1 (Y-DNA), also called C-M8, is a subclade of Y-DNA haplogroup C1a defined by the M8 marker, essentially restricted to Japanese and Ryukyuan males at about 5% or less, with subclades C1a1a1a and C1a1a1b, and linked to Jomon-period paternal lineages.

Haplogroup C2e2 (Y-DNA)

Haplogroup C2e2 is a Y-chromosome DNA subclade of haplogroup C2, defined by the SNP marker F845 and confirmed in a 2015 study of Korean men.

Haplogroup D1a1 (Y-DNA)

Haplogroup D1a1 (Y-DNA), also written D1A1, is an Asian patrilineal branch of haplogroup D-M174, estimated ~25,000 years old; subclade D1a1a1a1 (~19,000 years) is prevalent among Tibetan Plateau and Tibeto-Burman populations, distinct from mtDNA haplogroup D1.

Haplogroup E1a1 (Y-DNA)

Haplogroup E1a1 (Y-DNA), also called E-M44, is a paternal lineage defined by SNP M44 under E1a (M33, M132) in haplogroup E, an African-rooted Y-chromosome branch with a dedicated FamilyTreeDNA project.

Haplogroup H (mtDNA)

Haplogroup H (mtDNA), the dominant European maternal lineage within haplogroup HV, exceeds 40% frequency in Western Europe, was rare in Early Neolithic farmers and absent in Mesolithic hunter-gatherers, and rose via Neolithic and Bell Beaker expansions.

Haplogroup HV10 (mtDNA)

Haplogroup HV10 (mtDNA) is a rare maternal-line clade of haplogroup HV, defined by mutation C13449T within the former HV3 branch sharing T16311C; recorded in Serbian, Ashkenazi, and Belarusian samples and medieval Hungarian and Russian ancient DNA.

Haplogroup L0d1 (mtDNA)

Haplogroup L0d1 (mtDNA), a subclade of L0d within haplogroup L0, is one of the deepest-rooting human maternal lineages, carried mainly by Khoisan populations of southern Africa, with subclades L0d1a through L0d1d.

Haplogroup L1a1 (Y-DNA)

Haplogroup L1a1 (Y-DNA), also L-M27/L-L1320, is a South Asian Y-chromosome lineage under haplogroup L-M20, common in Central and South Asia, rare elsewhere, and associated with the Indus Valley.