72,234 articles
HB0017 (IL-17A antibody)
HB0017 is a humanized IgG1 monoclonal antibody against IL-17A by Shanghai Huaota (Huahai Pharmaceutical) for plaque psoriasis and ankylosing spondylitis; phase III met all endpoints and NMPA accepted its NDA.
HBA1
HBA1 (hemoglobin subunit alpha 1, alpha-1 globin) is one of two nearly identical alpha-globin genes on chromosome 16p13.3; with HBA2 it encodes the hemoglobin alpha chain, and its deletion causes alpha thalassemia.
HBA2
HBA2 (hemoglobin subunit alpha 2, Gene ID 3040) is one of two identical human alpha-globin genes on 16p13.3; it supplies most alpha-globin mRNA and its deletions or variants cause alpha-thalassemia, HbH disease, and Hb Bart syndrome.
HBEGF
HBEGF (HB-EGF, DTR) is a human EGF-family growth factor gene, secreted by macrophages, mitogenic for smooth muscle cells, and the membrane-anchored receptor for diphtheria toxin.
HBL-100
HBL-100 (CVCL_4362) is a human epithelial cell line established from breast milk, carrying tandemly integrated SV40 genomes and a Y chromosome; it is ICLAC-registered as misidentified and used as a breast epithelial model.
HBM7008 (B7-H4 x 4-1BB bispecific)
HBM7008 (CLN-418), Harbour BioMed's fully human B7-H4 x 4-1BB bispecific immune activator from the HBICE platform; Phase 1 in advanced solid tumors, licensed to Cullinan in 2023 for $25M upfront, terminated and returned in 2024.
HBM7022 (Claudin 18.2 x CD3 bispecific)
HBM7022 (AZD5863) is Harbour BioMed's fully human Claudin 18.2 x CD3 bispecific T-cell engager antibody, out-licensed globally to AstraZeneca in April 2022 for $25M upfront plus up to $325M milestones, now in Phase I solid tumor trials.
HBM9033 (MSLN ADC)
HBM9033 (PF-08052666, SGN-MesoC2) is a mesothelin-targeted antibody-drug conjugate with a camptothecin-based topoisomerase 1 inhibitor payload, DAR 8, developed by Harbour BioMed/Nona Biosciences, licensed to Pfizer for $53 million upfront plus up to $1.05 billion milestones, and discontinued in 2026 after a terminated Phase 1 trial.
HBsAg
HBsAg (hepatitis B surface antigen), formerly the Australia antigen, is the HBV envelope protein whose serum presence defines acute and chronic hepatitis B infection and whose quantification guides phase diagnosis and cure endpoints.
HbSC disease
HbSC disease is a compound heterozygous sickling hemoglobinopathy, milder than sickle cell anemia in anemia and stroke risk, yet prone to retinopathy, splenomegaly, and avascular necrosis.
HBTA
HBTA (high boiling tar acid) is a phenolic pesticide active substance, tar acids of the polyalkylphenol fraction (CAS 84989-05-9), notified as a disinfectant in the EU but not approved; distinct from HBTA abbreviations for 1-hydroxybenzotriazole and other compounds.
HCA Healthcare
HCA Healthcare (NYSE: HCA), formerly Hospital Corporation of America, is a Nashville-based for-profit hospital operator founded in 1968 by the Frists and Jack Massey; 190 hospitals, $75.6B 2025 revenue, largest US for-profit hospital chain.
HCC1806
HCC1806 is a human breast cancer cell line established in 1995 from a 60-year-old Black woman with squamous breast carcinoma, serving as a widely used model for triple-negative breast cancer.
HCC1937
HCC1937 (HCC-1937, CVCL_0290, ATCC CRL-2336) is a triple-negative, basal-like human breast cancer cell line established in 1995, homozygous for the BRCA1 5382insC mutation, with TP53 mutation and homozygous PTEN deletion, used to study BRCA1 and DNA repair.
HCC1954
HCC1954 (ATCC CRL-2338) is a human breast cancer cell line from a 1995 grade 3 invasive ductal carcinoma; HER2-overexpressing, ER/PR-negative, trastuzumab-resistant, used to test anti-HER2 drugs and antibody-drug conjugates.
HCC827
HCC827 (HCC-827, Hamon Cancer Center 827) is a human lung adenocarcinoma cell line from a 39-year-old woman, carrying EGFR exon 19 E746-A750 deletion, used to study EGFR-TKI sensitivity and acquired resistance mechanisms such as MET amplification.
HCFC1
HCFC1 (host cell factor C1, HCF-1, MRX3, XLID3) is an Xq28 gene encoding a transcriptional coregulator; kelch-domain variants cause cblX cobalamin disorder, proteolysis-domain variants focal epilepsy, others intellectual disability.
HCHS study
The Hamburg City Health Study (HCHS) is a large cohort study by the University Medical Center Hamburg-Eppendorf following 45,000 Hamburg residents to find chronic disease risk factors.
HCHS/SOL study
HCHS/SOL (Hispanic Community Health Study/Study of Latinos) is the largest US longitudinal cohort study of Hispanic/Latino health: 16,415 adults aged 18–74 at Bronx, Chicago, Miami, and San Diego centers, baseline 2008–2011, with ancillary studies and genotyping.
HCMV protein UL42
HCMV protein UL42, human cytomegalovirus immune-evasion protein, negative regulator of the cGAS/MITA (STING) innate antiviral response; its deletion raises type I interferon production. Distinct from HSV-1 UL42 processivity factor; HCMV's polymerase processivity factor is UL44.
HCN channels
HCN channels, or hyperpolarization-activated cyclic nucleotide-gated channels, are ion channels in heart and brain cell membranes, known as pacemaker channels for the funny current that sets the cardiac rhythm.
HCN4
HCN4 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 4, 15q24.1) is the slowest-activating HCN pacemaker channel, carrying about 80% of the sinoatrial funny current If; mutations cause sick sinus syndrome 2 and left ventricular noncompaction, and ivabradine blocks it.
HCRT
HCRT (hypocretin neuropeptide precursor, OX, PPOX) is the human 17q21.2 gene encoding prepro-orexin, the precursor of orexin-A and orexin-B, whose loss causes narcolepsy type 1.
HCSVD-TRC study
HCSVD-TRC (NCT06512376) is a Beijing Tiantan Hospital observational patient registry of hereditary cerebral small vessel disease, led by Yilong Wang, enrolling 100 gene-confirmed or suspected hCSVD patients for 5-year genetic, MRI, and clinical follow-up, 2022 to 2027.
HCT 116
HCT 116 (HCT116, HCT-116), a human colorectal carcinoma cell line from a male colon cancer patient, established 1981 by Brattain; MSI-high, KRAS G13D, wild-type TP53, ATCC CCL-247, NCI-60 member.
HCT 15
HCT-15 (HCT 15, CVCL_0292, ATCC CCL-225) is a human colorectal adenocarcinoma cell line from a male Dukes C patient, MSI-high, KRAS G13D, quasidiploid, genetically identical in origin to DLD-1, HCT-8, and HRT-18.
HCT 8
HCT 8 (HCT-8, HRT-18) is a human colorectal adenocarcinoma cell line from a 67-year-old male, MSI-positive with APC, KRAS G13D, and PIK3CA mutations, tumorigenic in nude mice, and genetically identical to DLD-1, HCT-15, and HRT-18.
HD domain
HD domain (histidine–aspartate domain, IPR003607): a metal-dependent phosphohydrolase protein domain in bacteria, archaea, and eukaryotes, with hydrolase, oxygenase, and lyase classes and over 318,000 members.
HD-related protein
HD-related protein: member of the histidine-aspartate (HD)-domain metalloprotein superfamily (HD-GYP, HDOD, HDIG variants), sharing one scaffold but catalyzing hydrolysis, oxygenation, or lyase reactions; many members remain hypothetical.
HDAC1
HDAC1 (histone deacetylase 1, UniProt Q13547) is a 482-aa class I zinc-dependent human deacetylase in NuRD, SIN3, CoREST, and MiDAC complexes; it represses p21/p27/p57, controls DNA repair, is embryonically essential, overexpressed in many cancers, and targeted by approved HDAC inhibitors.