5 articles
Azabicyclo[1.1.0]butane strain-release amination
Azabicyclo[1.1.0]butane strain-release amination is a reaction family in which the highly strained amine 1-azabicyclo[1.1.0]butane, or ABB, opens its bridging N1–C3 bond to give substituted azetidines used in pharmaceutical chemistry.
Bicyclo[1.1.0]butane strain-release cross-coupling
Bicyclo[1.1.0]butane strain-release cross-coupling is a set of synthetic methods where the central bond of bicyclo[1.1.0]butane is cleaved to form substituted cyclobutanes under nucleophilic, radical, or transition-metal-catalyzed conditions.
Strain-release chemistry
Strain-release chemistry is a branch of organic synthesis in which the stored energy of strained small rings drives bond-forming reactions under mild conditions, widely used in drug discovery.
Strain-release functionalization
Strain-release functionalization is a strategy in organic synthesis where the stored strain energy of a small-ring compound, chiefly bicyclo[1.1.0]butane, drives new bond formation under mild conditions.
Strain-release functionalization of bicyclobutanes
Strain-release functionalization of bicyclobutanes is a set of synthetic methods in which bicyclo[1.1.0]butanes' strained central C–C bond is cleaved, yielding functionalized cyclobutanes, bridged bicyclics, and heterocycles under mild conditions.