6 articles
Alpha helix (α-helix)
The alpha helix (α-helix) is the most prevalent motif of protein secondary structure, a right-handed spiral stabilized by hydrogen bonds, proposed by Pauling in 1951.
Beta sheet
A beta sheet, or β-pleated sheet, is a major secondary structure of proteins in which extended β-strands lie side by side, held together by hydrogen bonds between neighboring strands.
CHARMM36m
CHARMM36m (C36m) is an all-atom additive protein force field for molecular dynamics simulations, introduced in 2017 as a refinement of CHARMM36 with improved accuracy for folded and intrinsically disordered proteins.
Protein folding
Protein folding is the process by which a linear chain of amino acids acquires its functional three-dimensional native state; Anfinsen showed the sequence holds all needed information, and AlphaFold later predicted structures with high accuracy.
Protein structure
Protein structure, also known as protein conformation, is the three-dimensional organization of a protein molecule across four levels, from amino acid sequence to assembled multi-chain complexes, and it determines function.
Ramachandran plot
The Ramachandran plot, also called the Ramachandran diagram, is a graph of a polypeptide's backbone torsion angles φ and ψ, introduced by G. N. Ramachandran in 1963.