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Sam Bradford
Sam Bradford (born 1987) is a former NFL quarterback, 2008 Heisman winner at Oklahoma and first overall pick of the 2010 draft by the Rams; injuries limited him to 83 games, 19,449 yards, 103 touchdowns.
Sam Darnold
Sam Darnold, NFL quarterback (Seahawks, No. 14), drafted third overall by the Jets in 2018 out of USC; Pro Bowl 2024 with Minnesota (4,319 yards, 35 TDs), won Super Bowl LX in his first 2025 Seattle season.
Sam Ehlinger
Sam Ehlinger (born 1998, Austin, Texas) is an NFL quarterback from Texas; drafted 218th overall by the Colts in 2021, he threw for 11,436 college yards, started three games in 2022, and is now with the Denver Broncos.
Sam Hartman
Sam Hartman (born 1999) is an American quarterback, Wake Forest and Notre Dame, ACC-record 134 passing TDs and 15,656 yards; undrafted 2024, Washington Commanders practice squad.
Sam Hecht (American football)
Sam Hecht (born 2003) is an NFL center for the Carolina Panthers, drafted 144th overall in 2026 from Kansas State; a former walk-on who started 25 games without allowing a sack.
Sam Horn (American football)
Sam Horn (born 2003) is a Missouri Tigers quarterback and right-handed pitcher from Lawrenceville, Georgia, drafted by the Dodgers in the 17th round of the 2025 MLB draft; Tommy John surgery ended his 2024 season and a fractured tibia ended his 2025 football season.
Sam Howell
Sam Howell (born 2000) is an NFL quarterback from Indian Trail, North Carolina; a record-setting North Carolina Tar Heels passer drafted 144th overall in 2022 by Washington, later with Seattle, Minnesota, Philadelphia, and Dallas.
Sam Hubbard
Sam Hubbard (born 1995) is a retired Cincinnati Bengals defensive end, drafted 77th overall in 2018 from Ohio State; famous for the NFL playoff-record 98-yard fumble return TD, 38.5 career sacks, and retirement in March 2025.
Sam LaPorta
Sam LaPorta, Detroit Lions tight end from Highland, Illinois and Iowa; 2023 second-round pick (34th overall) who set the NFL rookie tight end record with 86 catches, 889 yards, 10 touchdowns.
Sam Leavitt (American football)
Sam Leavitt, LSU Tigers quarterback (No. 10), formerly Michigan State and Arizona State; 2024 Big 12 Freshman of the Year, 2,885 passing yards, 24 TDs; No. 1 2026 transfer portal QB; 2027 NFL Draft prospect.
Sam Mills
Sam Mills (Samuel Davis Mills Jr.), NFL linebacker for the Saints and Panthers, 5x Pro Bowl, 'Dome Patrol' member, 'Keep Pounding' inspiration, died 2005, Pro Football Hall of Fame Class of 2022.
Sam Pittman
Sam Pittman, born 1961 in El Reno, Oklahoma, is an American college football coach who led the Arkansas Razorbacks from 2020 until being fired in September 2025.
Sam Roush
Sam Olsen Roush (born 2003) is an American football tight end for the Chicago Bears, drafted 69th overall in 2026 after playing college football at Stanford.
Sam Salz (American football)
Sam Salz, Philadelphia-born Orthodox Jewish wide receiver (5'6", 160 lbs, No. 39) who walked on at Texas A&M with no football experience; first known Orthodox Jewish player in NCAA Division I football, Shabbat-observant.
Sam Wyche
Sam Wyche (1949-2020), NFL head coach of the Cincinnati Bengals 1984-91 and Tampa Bay Buccaneers 1992-95, introduced the no-huddle offense and led the 1988 AFC champion Bengals to Super Bowl XXIII.
Samaje Perine
Samaje Perine, NFL running back (Cincinnati Bengals, No. 34), Oklahoma record-setter with 427-yard NCAA single-game rushing game; ten seasons with Washington, Bengals, Miami, Denver, and Kansas City.
Sammy Baugh
Sammy Baugh (Slingin' Sammy), 1914-2008, Hall of Fame quarterback, punter, and defensive back for the Washington Redskins 1937-1952; led NFL in passing, punting, and interceptions in 1943 and won titles in 1937 and 1942.
Sammy Watkins
Sammy Watkins, born 1993, is a former NFL wide receiver from Clemson drafted fourth overall by Buffalo in 2014; he later won Super Bowl LIV with the Kansas City Chiefs.
Santana Moss
Santana Moss (Santana Terrell Moss, born 1979) is a former NFL wide receiver, not Randy Moss, who played for the New York Jets and Washington from 2001 to 2014, totaling 732 catches, 10,283 yards, 66 touchdowns, and one 2005 Pro Bowl.
Santonio Holmes
Santonio Holmes, born 1984 in Belle Glade, Florida, is a retired NFL wide receiver (Steelers, Jets, Bears) and Super Bowl XLIII MVP famous for the toe-tap game-winning catch; later a Central State coach and 10 ALL IN Foundation co-founder.
Saquon Barkley
Saquon Barkley, NFL running back for the Philadelphia Eagles, drafted second overall by the Giants in 2018; 2024 AP Offensive Player of the Year with 2,005 rushing yards, 2,504 including playoffs, and Super Bowl LIX champion.
Sarah Thomas (American football official)
Sarah Thomas is an American football official who in 2015 became the NFL's first full-time female official and the first woman to work an NFL playoff game.
Sauce Gardner
Ahmad "Sauce" Gardner is an American cornerback for the Indianapolis Colts, drafted fourth overall in 2022 by the Jets and named AP Defensive Rookie of the Year.
Savion Williams
Savion Williams, Green Bay Packers wide receiver, former TCU dual-threat playmaker from Marshall, Texas; 2025 third-round pick (No. 87), 4.48-second 40-yard dash, 2024 season with 6 receiving and 6 rushing touchdowns.
Sawyer Robertson
Sawyer Robertson, Baylor quarterback from Lubbock, Texas; former Mississippi State four-star recruit; threw 7,616 yards and 61 TDs in three Baylor seasons, second-team All-Big 12 in 2025, signed by the Raiders as an undrafted free agent.
Scott Frost
Scott Frost, American college football coach, UCF Knights head coach since December 2024; led UCF to 13-0 in 2017, went 16-31 at Nebraska 2018-22, and is suing Nebraska over contract payments.
Scott Norwood
Scott Norwood (born 1960) is a former Buffalo Bills placekicker (1985-1991), the franchise's all-time scoring leader with 670 points, famous for the "Wide Right" 47-yard missed field goal that decided Super Bowl XXV.
Scott Pioli
Scott Pioli, NFL executive and NFL Network analyst; Patriots VP of player personnel 2002-08 with three Super Bowls, Chiefs GM 2009-12 (23-41, fired 2013), later Falcons assistant GM.
Scott Tolzien
Scott Tolzien (Toll-ZEEN), former NFL backup quarterback (49ers, Packers, Colts) and Wisconsin's 2010 Johnny Unitas Golden Arm winner; now quarterbacks coach of the New Orleans Saints after five seasons with the Dallas Cowboys.
Sean Desai
Sean Desai (born 1983, Shelton, Connecticut) is an NFL coach, Bengals senior defensive assistant, former Bears and Eagles defensive coordinator, first Indian American NFL coordinator, Temple doctorate in education.