519,064 articles
Tirabrutinib
Tirabrutinib (Velexbru; ONO-4059, GS-4059) is Ono Pharmaceutical's second-generation covalent BTK inhibitor, approved in Japan since 2020 for relapsed/refractory primary CNS lymphoma and Waldenström macroglobulinemia, dosed 480 mg once daily fasting.
Tiraera
Tiraera, also spelled tiradera, is the Spanish-language term for diss tracks and lyrical feuds in reggaeton, Latin trap, and Puerto Rican hip-hop, a tradition that grew from the 1990s underground cassette scene.
Tiragabadara Saami
Tiragabadara Saami (తిరగబడ్డారు సామి), also spelled Thiragabadara Saami, is a 2024 Telugu action drama directed by A.S. Ravi Kumar Chowdary, starring Raj Tarun and Malvi Malhotra; released 2 August 2024, it flopped with about ₹0.61 crore gross.
Tiragolumab
Tiragolumab (MTIG7192A, RG6058) is Roche's fully human anti-TIGIT IgG1 monoclonal antibody, given 600 mg every 3 weeks with atezolizumab; phase III lung cancer trials failed, but SKYSCRAPER-08 succeeded in esophageal squamous cell carcinoma.
Tirah Campaign
The Tirah Campaign was a British Indian frontier war of 1897–98 against the Afridi and Orakzai Pashtun tribes of the Tirah country, ending with the tribes defeated, fined, and disarmed.
Tiramakhan Traore
Tiramakhan Traoré is a general of the Mali Empire under Sundiata Keita known only through oral tradition, which credits him with conquering Kaabu in the Sunjata epic.
Tiramisu
Tiramisu (tiramisù, tiramesù) is a chilled Italian dessert of coffee-soaked savoiardi layered with mascarpone, egg, and sugar cream, dusted with cocoa. Codified at Le Beccherie in Treviso in the early 1970s; recipe deposited by the Accademia Italiana della Cucina.
Tiran Island (جزيرة تيران)
Tiran Island (جزيرة تيران), an uninhabited Red Sea island in the Strait of Tiran at the mouth of the Gulf of Aqaba, transferred from Egyptian administration to Saudi sovereignty by the 2016–2017 maritime delimitation agreement.
Tirana
Tirana (Tiranë), capital and largest city of Albania since 1920; 598,176 residents (2023 census), about 42% of national GDP, marked by Italian-era planning, communist demolition, and a post-1991 construction boom.
Tirana (district)
Rrethi i Tiranës (Tirana District) was Albania's most populous historic district, 717,426 people, centered on the capital; abolished by Law 8653 on 31 July 2000 and replaced by the 12-region structure.
Tirana International Airport Nënë Tereza
Tirana International Airport Nënë Tereza, also known as Rinas Airport or Nënë Tereza Airport, is Albania's principal international airport, located 17 km from Tirana and named after Mother Teresa.
Tirana Zoo
Tirana Zoo (Parku Zoologjik i Tiranës), Albania's only public zoo, opened in 1966, was rebuilt for 7 million euros, and reopened in June 2022 with about 160 animals amid continuing welfare criticism.
Tirana's Rock
Tirana's Rock, also called the Skanderbeg Building, is an 85-meter mixed-use high-rise in Tirana, Albania, designed by MVRDV, whose curved balconies sculpt the head of national hero Skanderbeg.
Tiranga (1993 film)
Tirangaa (तिरंगा, Tricolour), 1993 Hindi patriotic action drama by Mehul Kumar starring Raaj Kumar and Nana Patekar against terrorist Pralaynath Gendaswamy; blockbuster, bombed at Plaza cinema in the 1993 Bombay attacks.
Tirant lo Blanc
Tirant lo Blanc, also known as Tirant lo Blanch, is a Catalan chivalric romance by Joanot Martorell and Martí Joan de Galba, first printed in Valencia in 1490.
TIRAP
TIRAP (MAL, MyD88 adaptor-like), TIR domain-containing adaptor protein, human gene on chromosome 11; a sorting adaptor recruiting MyD88 to TLR2 and TLR4 via a PIP2-binding motif, enabling NF-κB and MAPK inflammatory signaling.
Tirapazamine
Tirapazamine (TPZ, SR 4233, WIN 59075) is an investigational hypoxia-activated prodrug, first reported 1986, that kills oxygen-poor tumor cells via reductase-generated DNA-damaging radicals; its phase III HeadSTART trial showed no survival benefit and it was never FDA-approved.
Tirasemtiv
Tirasemtiv (CK-2017357), a Cytokinetics fast skeletal muscle troponin activator for ALS, slowed vital capacity and strength decline in phase IIb but failed its phase III VITALITY-ALS primary endpoint; development suspended 2017.
Tiraspol (Тираспол)
Tiraspol (Тираспол), founded 1792 by Suvorov, is the de facto capital of unrecognized Transnistria in eastern Moldova on the Dniester's left bank; about 128,000 people, dominated by the Sheriff conglomerate and hit by the 2025 Russian gas cutoff.
Tiratricol
Tiratricol (Triac, Emcitate), a T3 thyroid hormone analogue that enters cells without the MCT8 transporter; first approved treatment for peripheral thyrotoxicosis in MCT8 deficiency (Allan-Herndon-Dudley syndrome), EU 2025, US 2026.
Tiraz
Tiraz (Arabic: طراز, ṭirāz) is a medieval Islamic inscribed textile, its Arabic inscription band, or the state workshop that made it, given as robes of honor until the thirteenth century.
Tirbanibulin
Tirbanibulin (Klisyri, formerly KX2-391) is a topical microtubule and Src kinase inhibitor ointment applied once daily for 5 days to treat actinic keratosis of the face or scalp, FDA-approved December 2020.
Tire
A tire, or pneumatic tire, is a ring-shaped component fitted around a wheel rim that carries a vehicle's load and provides traction for driving, braking, and steering.
Tire code
The tire code is the letters and numbers molded into a tire's sidewall giving its size, load capacity, and speed rating, such as P225/60R16 97T.
Tire-pressure monitoring system
A tire-pressure monitoring system (TPMS) is an electronic vehicle system that warns the driver when tire pressure is low, using either direct pressure sensors or indirect wheel-speed inference.
Tired light
Tired light is a class of non-expanding cosmological models proposed by Fritz Zwicky in 1929, in which redshift comes from photons losing energy in transit rather than cosmic expansion.
Tirela family
Tirela family (also Klumpkea/Tirela): outer main-belt asteroid family named for asteroid 1400 Tirela, identified by Nesvorný et al. 2005 as a D-group, later reclassified Ld/L-type, with high eccentricity and inclination and bimodal albedo.
Tires (TV series)
Tires is a Netflix workplace sitcom co-created by Shane Gillis, Steve Gerben, and John McKeever, set at the Valley Forge auto repair shop; self-funded after a 2019 YouTube pilot, it premiered May 23, 2024 and has been renewed through Season 4.
Tiresias (Τειρεσίας)
Tiresias (Τειρεσίας, Teiresias), blind seer of Thebes in Greek mythology who lived as both man and woman, judged Zeus and Hera's dispute, advised Oedipus, Pentheus, and Odysseus, and died at a spring.
Tîrgşor
Tîrgșor, also written Târgșor, is a locality in Prahova County, Romania, southwest of Ploiești, known for an archaeological reservation spanning the Paleolithic to the Middle Ages.