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Trastuzumab
Trastuzumab (Herceptin) is a humanized anti-HER2 monoclonal antibody from Genentech, FDA-approved in 1998 for HER2-positive breast cancer and later gastric cancer, with biosimilars and ADC derivatives now in wide use.
Trastuzumab botidotin for injection
Trastuzumab botidotin (博度曲妥珠单抗, A166, brand Shutaile) is a Kelun-Biotech HER2-targeting antibody-drug conjugate with a Duo-5 (MMAF-derivative) payload, DAR 2, approved by China's NMPA in October 2025 for previously treated HER2-positive metastatic breast cancer.
Trastuzumab brengitecan
Trastuzumab brengitecan (T-Bren, BL-M07D1) is a Sichuan Baili HER2-directed antibody-drug conjugate using the Ed-04 topoisomerase I inhibitor payload, GGFG cathepsin B-cleavable linker, and DAR 8, in phase 3 breast cancer trials.
Trastuzumab deruxtecan
Trastuzumab deruxtecan (Enhertu, T-DXd, DS-8201a) is a HER2-directed antibody-drug conjugate linking trastuzumab to the topoisomerase I inhibitor DXd, approved for HER2-positive, HER2-low, and HER2-mutant cancers.
Trastuzumab duocarmazine
Trastuzumab duocarmazine (SYD985, T-Duo, Jivadco) is a HER2-targeted antibody-drug conjugate linking trastuzumab to the duocarmycin prodrug seco-DUBA; it met PFS endpoint in the TULIP phase III trial but its EMA application was withdrawn.
Trastuzumab emtansine
Trastuzumab emtansine (T-DM1, Kadcyla), an antibody-drug conjugate of trastuzumab and the tubulin inhibitor DM1; first ADC approved for a solid tumor (2013) for HER2-positive breast cancer.
Trastuzumab envedotin
Trastuzumab envedotin (DP303c) is a CSPC-developed HER2-targeted antibody-drug conjugate: trastuzumab-sequence IgG1 with site-specific MMAE conjugation (DAR 2.0), phase 3 PFS 8.8 vs 5.8 months versus T-DM1 in HER2-positive advanced breast cancer.
Trastuzumab pamirtecan
DB-1303 (trastuzumab pamirtecan, BNT323) is DualityBio's third-generation HER2-targeting antibody-drug conjugate with a topoisomerase I inhibitor payload; its Phase 3 breast cancer trial met its PFS endpoint and China's NMPA accepted its BLA in 2026.
Trastuzumab regimen
A trastuzumab regimen is a cancer treatment pairing trastuzumab, a monoclonal antibody against the HER2 receptor, with chemotherapy, used mainly in HER2-positive breast and gastric cancers.
Trastuzumab vedotin
Trastuzumab vedotin (MRG002) is an investigational HER2-targeting antibody-drug conjugate: fucosylated trastuzumab (MAB802) linked to MMAE via a Val-Cit linker, DAR 3.8, in phase I/II trials for HER2-positive and HER2-low breast and gastric cancers.
Tratado Descritivo do Brasil
The Tratado Descritivo do Brasil, offered in Madrid in 1587, is a treatise on colonial Brazil by the Bahia sugar-mill owner Gabriel Soares de Sousa.
TRATON
TRATON is a Munich-based European commercial vehicle manufacturer and listed subsidiary of Volkswagen AG, which owns 87.52% and holds the brands Scania, MAN, International, and Volkswagen Truck & Bus.
Traudl Junge
Traudl Junge, born Gertraud Humps, was the youngest of Adolf Hitler's personal secretaries from late 1942 until 1945, later known for her memoir Until the Final Hour.
Trauerspiel
Trauerspiel (German for "mourning play") is a German dramatic genre, the baroque mourning drama of seventeenth-century Silesia written by authors like Andreas Gryphius and Lohenstein.
Trauffer
Trauffer is the stage name of Marc A. Trauffer, a Swiss Mundart-pop singer from the Bernese Oberland who has topped the Swiss album charts since 2014.
Trauma center
Trauma center: hospital specialized in definitive care of severely injured patients, classified ACS Levels I-V, designated by states and verified by the ACS; first U.S. centers opened 1966, Shock Trauma Center 1969.
Trauma laparotomy
Trauma laparotomy is an emergency operation in which the abdomen is opened to find and repair life-threatening internal injuries after blunt or penetrating trauma, the standard of care for unstable patients.
Trauma team activation
Trauma team activation (TTA) is a hospital protocol that summons a designated trauma team before or upon arrival of a patient with suspected major trauma.
Trauma-sensitive yoga
Trauma-sensitive yoga is yoga adapted for trauma survivors, using gentle Hatha-based practice, invitational language, and participant choice; a 2014 trial found it reduced PTSD symptoms.
Traumatic amputation of thumb
Traumatic amputation of thumb (ICD-11 NC59.0): accidental severing of the thumb by saws, crush, or avulsion. Managed by microsurgical replantation when feasible, else toe transfer, pollicization, or revision amputation.
Traumatic aortic rupture
Traumatic aortic rupture, or blunt traumatic aortic injury (BTAI), is a deceleration tear of the aorta, usually at the isthmus, from motor vehicle crashes; 80% die prehospital, diagnosed by contrast CT, treated mainly with delayed TEVAR.
Traumatic asphyxia
Traumatic asphyxia, also called Perthes syndrome or masque ecchymotique, is a rare crush-injury syndrome from thoracic compression causing cervicofacial cyanosis, petechiae, and subconjunctival hemorrhage via valveless SVC backflow.
Traumatic avascular necrosis
Traumatic avascular necrosis is bone death after injury, when fracture or dislocation cuts a bone's blood supply; typical sites are the femoral head, scaphoid, talus, and proximal humerus.
Traumatic bonding
Traumatic bonding, or trauma bonding, is the emotional attachment a victim develops toward an abuser through intermittent abuse and reward, distinct from Stockholm syndrome and from bonding over shared trauma.
Traumatic brain injury
Traumatic brain injury (TBI), also called concussion in its mild form, is brain dysfunction from a bump, blow, jolt, or penetrating head injury; classified by Glasgow Coma Scale as mild, moderate, or severe, causing about 69 million injuries yearly.
Traumatic cataract
Traumatic cataract: lens opacity from blunt, penetrating, radiation, electrical, or chemical eye injury; occurs in 27-65% of ocular trauma; rosette morphology; managed by globe closure then cataract extraction with IOL.
Traumatic cerebral oedema
Traumatic cerebral oedema (ICD-11 NA07.2) is fluid accumulation in brain tissue after traumatic brain injury, occurring in over 60% of mass-lesion cases. Subtypes include cytotoxic, vasogenic, and ionic edema; treatment uses hyperosmolar therapy, CSF drainage, and decompressive craniectomy, with corticosteroids contraindicated.
Traumatic haemopneumothorax
Traumatic haemopneumothorax (ICD-11 NB32.2, ICD-10 S27.2) is blood and air in the pleural space after chest injury, common after penetrating trauma, diagnosed by eFAST and CT, and managed by observation, chest drainage, or VATS.
Traumatic haemothorax
Traumatic haemothorax is a collection of blood in the pleural space between the lung and chest wall, caused by blunt or penetrating trauma and usually treated with a chest tube.
Traumatic insemination
Traumatic insemination, or hypodermic insemination, is mating in which males pierce the partner's body wall and inject sperm into the body cavity, best known in bed bugs (Cimex lectularius), with the spermalege as female counter-adaptation and repeated independent origins across arthropods.