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Edgepedia

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ATG-201

ATG-201 is Antengene's investigational "2+1" CD19/CD3 bispecific T-cell engager for B cell-related autoimmune diseases, using steric hindrance masking to lower CRS risk; UCB licensed it worldwide in March 2026 for up to about USD 1.2 billion.

ATG12

ATG12 (autophagy related 12; APG12, HGNC:588) is a ubiquitin-like protein conjugated to ATG5 by ATG7 and ATG10; the ATG12–ATG5–ATG16 complex acts as an E3-like enzyme for ATG8 lipidation in autophagy.

ATG16L1

ATG16L1 (autophagy related 16 like 1) is a 561-amino-acid human autophagy protein; its T300A/rs2241880 variant is a Crohn's disease risk factor affecting Paneth cells and innate immune cytokine regulation.

ATG5

ATG5 (autophagy related 5, APG5) is a human chromosome 6q21 gene encoding a core autophagy protein; conjugated to ATG12, it forms an E3-like complex with ATG16L1 for LC3 lipidation, with knockout, disease, and cancer roles.

ATG7

ATG7, or autophagy-related gene 7, is an E1-activating enzyme that powers the ATG12 and ATG8/LC3 conjugation systems required for autophagosome formation, and whose pathogenic variants cause a childhood neurodevelopmental disorder.

ATG8 conjugation and lipidation enzymes

ATG8 conjugation and lipidation enzymes (ATG4 proteases, ATG7, ATG3, ATG12–ATG5–ATG16) attach LC3/GABARAP proteins to phosphatidylethanolamine during autophagy, mediating priming, PE-conjugation, and de-lipidation.

ATG9A

ATG9A (APG9L1, mATG9), autophagy related 9A, is a human protein-coding gene at 2q35 encoding the only multi-pass transmembrane protein of the core autophagy machinery, a homotrimeric phospholipid scramblase essential for autophagosome formation and membrane repair.

Atget (Mercurian crater)

Atget: 100-km-diameter impact crater within Mercury's Caloris basin, just south of its center; IAU feature ID 14394; named for French photographer Eugène Atget; imaged at 88 m/pixel by MESSENGER in 2011; its low-reflectance ejecta record Caloris stratigraphy.

Athabasca (lake)

Lake Athabasca, largest lake in Saskatchewan (7,935 km2, 213 m), straddling the Saskatchewan-Alberta border; fed by Peace, Athabasca, and Fond du Lac rivers, drains via Slave River to Great Slave Lake; Cree name, fur-trade hub, gold and uranium mining.

Athabasca (river)

Athabasca River, Alberta river over 1,200 km from Jasper National Park to Lake Athabasca; fur trade route, Athabasca Pass 1811, heritage river 1989, main water source for oil sands mining.

Athabasca Glacier

Athabasca Glacier, an outlet glacier of the Columbia Icefield in Jasper National Park, Alberta; Canada's most accessible glacier, 8.3 km long, retreating since its 1843/4 Little Ice Age maximum and thinned 60 m from 1961 to 2020.

Athabasca Indigenous Investments

Athabasca Indigenous Investments is a limited partnership of 23 First Nation and Métis communities in northeast Alberta holding an 11.57% stake in seven Enbridge pipelines.

Athabasca Oil Corporation

Athabasca Oil Corporation is a Calgary-based Canadian oil and gas producer with SAGD bitumen projects at Leismer and Hangingstone in Alberta's Athabasca oil sands, plus Duvernay light oil.

Athabasca Oil Pipeline

The Athabasca Oil Pipeline, Enbridge Line 19, is a crude oil pipeline in Alberta running 542 km from Fort McMurray to Hardisty, in service since 1999.

Athabasca oil sands

The Athabasca oil sands, also called the Athabasca Tar Sands, are a large deposit of bitumen-bearing sand in northeastern Alberta near Fort McMurray, the largest of Alberta's three oil sands areas.

Athabasca Oil Sands Project

The Athabasca Oil Sands Project (AOSP) is an oil sands operation in northern Alberta combining the Muskeg River and Jackpine mines with the Scotford Upgrader, producing about 328,000 barrels daily.

Athabasca Sand Dunes Provincial Park

Athabasca Sand Dunes Provincial Park is a wilderness park in northern Saskatchewan, protecting Canada's largest active sand dunes, the most northerly in the world, and endemic plants.

Athabasca, Alberta

Athabasca is a town in northern Alberta, 145 km north of Edmonton on the Athabasca River; formerly Athabasca Landing, a fur-trade gateway to the North, it had 2,759 people in 2021.

Athabaskan brainstem dysgenesis syndrome

Athabaskan brainstem dysgenesis syndrome (ABDS, formerly Navajo brainstem syndrome) is a rare autosomal recessive HOXA1 disorder of Navajo and Apache children causing horizontal gaze palsy, deafness, central hypoventilation, and developmental delay.

Athabaskan languages

Athabaskan (Dene) is a family of about forty Indigenous North American languages. Spoken in Alaska, western Canada, and the American Southwest, it is the core of Na-Dene.

Athadu (అతడు)

Athadu (అతడు, "Him") is a 2005 Telugu action thriller directed by Trivikram Srinivas, starring Mahesh Babu as hitman Nandu who assumes a dead man's identity after being framed for a politician's murder; re-released in 4K in 2025.

Athaku Yamudu Ammayiki Mogudu (అత్తకి యముడు అమ్మాయికి మొగుడు)

Athaku Yamudu Ammayiki Mogudu (అత్తకి యముడు అమ్మాయికి మొగుడు), also spelled Attaku Yamudu Ammayiki Mogudu, is a 1989 Telugu action comedy-drama directed by A. Kodandarami Reddy, starring Chiranjeevi, Vijayashanti, and Vanisri, released 14 January 1989 and remade in Tamil as Mappillai.

Athaliah (עֲתַלְיָה)

Athaliah was a queen of Judah who reigned from 841 to 835 BC, the only ruling queen in the biblical record, before being deposed by the priest Jehoiada.

Athalie

Athalie is a five-act verse tragedy by Jean Racine, his last play, first performed in 1691 and drawn from the biblical story of the usurping queen Athaliah.

Athame

An athame is a usually black-handled ritual knife used in Wicca and related magical traditions to direct energy and cast the ritual circle, not for cutting.

Athan Kuliopulos

Athan Kuliopulos is an American molecular biologist at Tufts Medical Center who co-developed pepducins, cell-penetrating peptides that switch GPCR signaling, and showed MMP-1 activates PAR1.

Athanasian Creed

The Athanasian Creed, also called Quicumque Vult, is a Christian profession of faith setting out the Trinity and the incarnation, probably written in southern Gaul in the fifth or sixth century.

Athanasios Davakis

Athanasios Davakis (Greek: Θανάσης Δαβάκης), born in 1962, is a Greek New Democracy politician and lawyer who has represented Laconia in parliament since 1993 and serves as Deputy Minister of National Defence.

Athanasios Diakos

Athanasios Diakos (Αθανάσιος Διάκος), born Athanasios Massavetas, was a Greek armatolos who became an early hero of the Greek War of Independence, dying impaled in 1821.

Athanasios Nenes

Athanasios Nenes (Αθανάσιος Νενές) is a Greek atmospheric scientist and professor at EPFL in Switzerland, known for the ISORROPIA aerosol models and research on how particles affect clouds and climate.