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Edgepedia

519,064 articles

tRNA-splicing endonuclease subunit Sen15

Sen15 (TSEN15) is the smallest, noncatalytic structural subunit of the eukaryotic tRNA splicing endonuclease heterotetramer, pairing with Sen34; loss-of-function mutations cause pontocerebellar hypoplasia type 2.

tRNA(Ile2) 2-agmatinylcytidine synthetase

tRNA(Ile2) 2-agmatinylcytidine synthetase, also called tRNA(Ile2) agmatidine synthetase (TiaS), is an archaeal enzyme that attaches agmatine to the wobble cytidine of isoleucine tRNA, producing agmatidine, required for accurate AUA decoding.

tRNA/rRNA methyltransferase LasT, C-terminal domain

LasT C-terminal domain (InterPro IPR063618): auxiliary RNA-binding CTD of LasT, an uncharacterized E. coli tRNA/rRNA methyltransferase (b4403, K02533) in the SPOUT TrmJ/LasT family; the Cm32/Um32 activity belongs to TrmJ, not LasT.

tRNAHis guanylyltransferase catalytic domain

tRNAHis guanylyltransferase catalytic domain (Thg1): the RRM-fold polymerase-palm enzyme core that adds G−1 to tRNAHis in the reverse 3′–5′ direction via adenylylation, nucleotidyl transfer, and pyrophosphate removal, using a two-metal-ion mechanism.

Trnava, Slovakia

Trnava (Trnavský kraj) is one of Slovakia's eight self-governing regions, in western Slovakia, with the city of Trnava as its capital and about 566,000 people.

TRNT1-related SIFD

TRNT1-related SIFD is an autosomal recessive disorder caused by variants in the TRNT1 gene, combining sideroblastic anemia, recurrent fevers, B-cell immunodeficiency, and developmental delay, first described in 2013.

Troades

Troades ("The Trojan Women") is a first-century AD Latin tragedy in five acts by Seneca the Younger, reworking Euripides to dramatize the deaths of Astyanax and Polyxena after Troy's fall.

Troas (region)

Troas (Τρωάς), also known as the Troad, is an ancient region in northwestern Asia Minor whose strategic position beside the Hellespont made it prized, and which contains Troy.

Trobriand oral literature

Trobriand oral literature is the spoken myth, story, song, and magic of the Trobriand Islands of Papua New Guinea, transmitted largely in the Kilivila language.

Trocar

A trocar is a surgical device that pierces the body wall to place a cannula, creating an access channel for instruments, optics, and gas, especially in laparoscopy.

Trochaic tetrameter

Trochaic tetrameter is a verse meter built from four trochees, one of the three primary measures of classical Greek and Latin verse, used in drama for hurried or excited dialogue.

Trochidae

Trochidae, the top shells, is the largest family of Trochoidea vetigastropod marine snails, with over 600 species in conical, nacreous-shelled, corneous-operculum grazers and filter feeders worldwide.

Trochilus

Trochilus is a genus of hummingbirds established by Linnaeus in 1758, now containing only the two Jamaican streamertails, which differ chiefly in bill color: red in the Red-billed Streamertail and black in the Black-billed Streamertail.

Trochlear nerve

Trochlear nerve (CN IV), fourth cranial nerve, purely motor to the superior oblique muscle; smallest cranial nerve with the longest intracranial course and the only dorsal brainstem exit; palsy causes vertical diplopia and head tilt.

Trochoidea (superfamily)

Trochoidea (Rafinesque, 1815), also called Trochacea, is the largest vetigastropod snail superfamily, over 2,000 species of top and turban shells worldwide, with a Middle Triassic fossil record and unstable family-level classification.

Trochophore and early larval development in gastropods

The trochophore is an early free-swimming larval stage of many marine molluscs, including gastropods, arising from spiral cleavage and swimming by bands of cilia until it becomes a veliger larva.

Troels Skrydstrup

Troels Skrydstrup is a Danish organic chemist and professor at Aarhus University, known for catalysis with small gaseous molecules, CO2 utilization, and catalytic recycling of thermoset plastics.

Troels Troels-Lund

Troels Troels-Lund (1840–1921) was a Danish cultural historian whose 14-volume Daily Life in the Nordic Countries in the Sixteenth Century, published 1879–1901, depicted ordinary life in Denmark and Norway.

Troeven

Troeven, Dutch for "trumps", is a four-player partnership point-trick card game from southern Limburg, a 32-card variant of Belgian Couillon with tree-branch scoring, described by Harry Tiggelovend.

Troff

Troff, known on some systems as ditroff, is a document formatting program developed at Bell Labs for Unix around 1973, still the standard formatter of Unix manual pages.

Trofim Lomakin

Trofim Lomakin (Трофим Фёдорович Ломакин, 1924–1973), Soviet weightlifter: 1952 Helsinki Olympic light-heavyweight gold (417.5 kg total), 1960 Rome silver, world champion 1957 and 1958, ten world records, career ruined by alcoholism.

Trofim Lysenko (Трофи́м Дени́сович Лысе́нко)

Trofim Denisovich Lysenko (Трофи́м Дени́сович Лысе́нко, 1898–1976), Soviet agronomist behind Lysenkoism and Michurinism: rejected Mendelian genetics, promoted vernalization, dominated Soviet biology 1948–1965 until his 1965 downfall.

Trofinetide

Trofinetide, sold as Daybue, is a synthetic peptide drug approved in the United States in March 2023 as the first FDA-approved treatment for Rett syndrome.

Trofosfamide

Trofosfamide (TFF, Ixoten, A-4828) is an oral oxazaphosphorine prodrug metabolized mainly to ifosfamide; approved in Europe for lymphoma, used off-label as low-dose palliative/maintenance therapy in soft tissue sarcoma.

Troglav

Troglav (Veliki Troglav), 1,913 m, is the highest peak of the Dinara massif on the Croatia–Bosnia and Herzegovina border, in Livno municipality, BiH; distinct from a lower Troglav mountain near Kraljevo, Serbia.

Troglitazone

Troglitazone, sold as Rezulin, was the first thiazolidinedione approved in the United States for type 2 diabetes, in January 1997, and was withdrawn in March 2000 over sometimes fatal liver injury.

Troglodytes

Troglodytes (Vieillot, 1809) is a genus of wrens in Troglodytidae, including the House Wren and Eurasian wren; molecular phylogenies show it is paraphyletic, with northern species moved to Nannus.

Trogoderma granarium

Trogoderma granarium, the khapra beetle (EPPO code TROGGA), is a flightless dermestid beetle and A2 quarantine pest of stored grains, native to the Indian subcontinent, with diapausing larvae surviving up to six years.

Trogodytice

Trogodytice (Τρωγλοδυτική, Trogodytike), ancient Red Sea coastal region of the Trogodytes, from Suez to Bab al-Mandab in modern Eritrea and Sudan; home of Ptolemaic Berenike Trogodytika and Ptolemais of the Hunts.

Trogon

Trogon (genus, Brisson 1760) is the largest Neotropical trogon genus, family Trogonidae, order Trogoniformes, with a unique heterodactyl foot; recent 2023-2025 splits raised its species count and renamed several English names.