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U.S. Route 65

U.S. Route 65, or US 65, is a north-south United States Numbered Highway running 960 miles from Albert Lea, Minnesota, to Clayton, Louisiana, through Des Moines and Little Rock.

U.S. Route 66

U.S. Route 66, popularly known as the "Mother Road," ran about 2,400 miles from Chicago to Los Angeles through eight states; it was decommissioned in 1985.

U.S. Route 68

U.S. Route 68 (US 68) is a United States Numbered Highway about 552 miles long, running from Reidland, Kentucky, through Lexington to Findlay, Ohio. It was one of the original 1926 routes.

U.S. Route 7

U.S. Route 7 (US 7) is a 308-mile north–south United States highway in western New England, running from Norwalk, Connecticut, to Highgate Springs, Vermont, just south of the Canadian border.

U.S. Route 70

U.S. Route 70 (US 70) is a United States Numbered Highway running east-west for 2,385 miles from Atlantic, North Carolina, to Globe, Arizona, and is an original 1926 route.

U.S. Route 74

U.S. Route 74, also known as US 74 or the Andrew Jackson Highway, is a highway from Wrightsville Beach, North Carolina, to I-75 in Cleveland, Tennessee.

U.S. Route 8

U.S. Route 8 (US 8) is a 279.6-mile east-west United States Numbered Highway from Forest Lake, Minnesota, to Norway, Michigan, crossing northern Wisconsin and designated in 1926.

U.S. Route 85

U.S. Route 85, also known as US 85, is a north-south United States highway from Canada to Mexico, an original 1926 route and a major freight corridor.

U.S. Route 87

U.S. Route 87, or US 87, is a United States Numbered Highway running from Port Lavaca, Texas, on the Gulf Coast to Havre, Montana, through the Texas Panhandle and eastern New Mexico.

U.S. Route 89

U.S. Route 89, the National Park Highway, runs 1,215 miles from Flagstaff, Arizona to the Canadian border near Babb, Montana through seven national parks; originally a 1,600-mile border-to-border route designated in 1927.

U.S. Route 97

U.S. Route 97 (US 97) is a north-south United States highway running from the Canada–US border at Oroville, Washington, through eastern Washington and central Oregon to Weed, California.

U.S. Route 98

U.S. Route 98 (US 98) is a 928-mile east–west United States Numbered Highway running from Natchez, Mississippi, to Palm Beach, Florida, following the Gulf Coast for much of its length.

U.S. Route 99

U.S. Route 99 was a United States numbered highway, 1,499 miles from Blaine, Washington, to Calexico, California, decommissioned after Interstate 5 replaced it in the 1960s and 1970s.

U.S. Securities and Exchange Commission

U.S. Securities and Exchange Commission (SEC), independent federal regulator created by the Securities Exchange Act of 1934; protects investors, maintains fair markets, facilitates capital formation; five commissioners, oversees exchanges, broker-dealers, FINRA, and NRSROs.

U.S. Senior Open

U.S. Senior Open (United States Senior Open Championship), USGA national golf championship for players 50 and older since 1980; first won by Roberto De Vicenzo at Winged Foot; Miller Barber and Padraig Harrington hold three titles each.

U.S. Ski and Snowboard

U.S. Ski and Snowboard, legally the United States Ski Association, is the national governing body for Olympic and Paralympic skiing and snowboarding in the United States.

U.S. Ski and Snowboard Hall of Fame

The U.S. Ski and Snowboard Hall of Fame is the national hall of fame for American skiers and snowsport contributors, established in 1954 in Ishpeming, Michigan, with over 430 honored members.

U.S. Space & Rocket Center

The U.S. Space & Rocket Center is a state-owned space museum in Huntsville, Alabama, opened in 1970, home of Space Camp, and official visitor center for NASA's Marshall Space Flight Center.

U.S. standard clothing size

U.S. standard clothing size: voluntary body-measurement tables for American ready-to-wear, once set by NBS Commercial Standard CS215-58 (1958, withdrawn 1983), now maintained by ASTM International (D5585, D6240), with widespread vanity sizing.

U.S. state

U.S. state: one of 50 constituent units sharing sovereignty with the federal government, each with its own constitution. Distinguished by Tenth Amendment reserved powers, congressional admission under Article IV, and 144 state constitutions since 1776.

U.S. state and territory temperature extremes

The U.S. state and territory temperature extremes are NOAA-certified record highs and lows for all 50 states, D.C., and inhabited territories, including the 134°F Death Valley world record.

U.S. Steel

U.S. Steel, formally United States Steel Corporation, is an American steelmaker founded in Pittsburgh in 1901 by J.P. Morgan and Andrew Carnegie, acquired by Nippon Steel in 2025.

U.S. Steel Košice

U.S. Steel Košice (USSK) is an integrated steelmaker in Košice, Slovakia, and Central Europe's largest, founded as the state-owned VSŽ in 1959 and acquired by U.S. Steel in 2000.

U.S. Strategic Bitcoin Reserve

The U.S. Strategic Bitcoin Reserve is a Treasury program, created by executive order in March 2025, that holds forfeited bitcoin as a reserve asset rather than selling it.

U.S. Women's Open

U.S. Women's Open, oldest LPGA major (since 1946), USGA-conducted since 1953, 72-hole stroke play; 2026 champion Nelly Korda at Riviera, $12.5M purse; Rawls and Wright won four each.

U.S. Women's Open (bowling)

The U.S. Women's Open is a PWBA Tour major in women's bowling, a 56-game marathon with four oil patterns awarding the green jacket and $60,000 top prize; recent champions include Sin Li Jane, New Hui Fen, and Jillian Martin.

U.S. Xpress

U.S. Xpress is a Chattanooga, Tennessee-based truckload carrier founded in 1985 with about 7,200 tractors; Knight-Swift acquired it on July 1, 2023 for a total purchase price of $630.0 million.

U.S.–German Peace Treaty (1921)

The U.S.–German Peace Treaty of 1921, commonly called the Treaty of Berlin, restored peace between the United States and Germany after the Senate refused to ratify the Treaty of Versailles.

U.S.A. (trilogy)

U.S.A., also called Dos Passos's U.S.A. trilogy, is a trilogy of novels by John Dos Passos, collected in 1938 and treated as a landmark of American modernist fiction.

U(r)gia

U(r)gia, also Ugia, Urgia, or Ugium, an ancient Turdetan oppidum of Baetica near the Guadalquivir mouth, cited by Pliny as Urgia Castrum Iulium; a Caesarian municipium and Augustan colony, location uncertain (Torres de Alocaz or Espera).