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Atxa
Atxa is an archaeological site on a hill in Vitoria-Gasteiz, Álava, Spain, with a Second Iron Age settlement overlaid by a Roman military camp of the 1st century AD.
ATXN1
ATXN1 (ataxin 1, HGNC:10548) is a human protein-coding gene at 6p22.3 encoding the 815-aa nuclear protein ataxin-1; CAG repeat expansion (pathogenic above ~39 repeats) causes spinocerebellar ataxia type 1 via toxic gain of function.
ATXN2
ATXN2 (ataxin 2), gene at 12q24.12 encoding a 1,312-aa RNA-binding protein; CAG repeat expansion beyond 33 causes SCA2, intermediate 29-34 repeats raise ALS risk.
ATXN7
ATXN7 (ataxin 7) is a chromosome 3 gene encoding a SAGA deubiquitinase-module subunit; CAG repeat expansion in exon 3 causes spinocerebellar ataxia type 7 with ataxia and retinal blindness.
Atypical
Atypical is a Netflix comedy-drama (2017-2021, 4 seasons, 38 episodes) created by Robia Rashid, starring Keir Gilchrist as Sam Gardner, an autistic teen seeking love and independence; praised critically but debated as autism representation.
Atypical antipsychotic
Atypical (second-generation) antipsychotics, led by clozapine (US launch 1990), treat schizophrenia and bipolar disorder with fewer movement side effects than typical drugs; notable agents include risperidone, olanzapine, quetiapine, and aripiprazole.
Atypical chronic myeloid leukemia
Atypical chronic myeloid leukemia (aCML), renamed MDS/MPN with neutrophilia by WHO 2022, is a rare BCR::ABL1-negative MDS/MPN with dysplastic neutrophilia, ASXL1/SETBP1 mutations, median survival 12–20 months, and transplant as the only curative option.
Atypical cystic fibrosis
Atypical cystic fibrosis (non-classic CF), a milder CFTR-mutation disease affecting about 2% of CF patients, with pancreatic sufficiency, borderline sweat chloride, or single-organ disease, often diagnosed in adolescence or adulthood.
Atypical depression
Atypical depression, a major depressive disorder subtype with mood reactivity plus hypersomnia, hyperphagia, leaden paralysis, and rejection sensitivity; MAOI-responsive, immunometabolically distinct from melancholic depression.
Atypical hemolytic uremic syndrome
Atypical hemolytic uremic syndrome (aHUS) is a rare complement-mediated thrombotic microangiopathy causing hemolytic anemia, thrombocytopenia, and kidney injury, treated with eculizumab or ravulizumab.
Atypical juvenile parkinsonism
Atypical juvenile parkinsonism (ORPHA:391411) is a rare autosomal recessive, complex young-onset Parkinson disease with pyramidal signs, eye movement abnormalities, intellectual disability, ataxia, epilepsy, and psychiatric features, linked to ATP13A2, PLA2G6, FBXO7, DNAJC6, SPG11, SPG15, and SYNJ1.
Atypical lichen myxedematosus
Atypical lichen myxedematosus, an intermediate form of lichen myxedematosus (papular mucinosis), is a rare cutaneous mucinosis not meeting criteria for scleromyxedema or localized LM, with about 20 reported cases and unpredictable course.
Atypical MAP kinases
Atypical MAP kinases are the four mammalian mitogen-activated protein kinases, ERK3, ERK4, ERK7/8, and NLK, that fall outside the conventional ERK, p38, JNK, and ERK5 subfamilies and are not activated by canonical MAPKK cascades.
Atypical Meigs syndrome
Atypical (incomplete) Meigs syndrome, ORPHA:314466, is a rare benign ovarian tumor disorder with pleural effusion but no ascites; the effusion resolves after tumor resection. Prevalence under 1 in 1,000,000; distinct from pseudo-Meigs and Tjalma syndromes.
Atypical melanocytic naevus
Atypical melanocytic naevus (atypical mole, dysplastic nevus, Clark nevus): a benign acquired mole with melanoma-like clinical features, ICD-11 2F20.1, a strong melanoma risk marker, strongest under age 40.
Atypical papilloma of choroid plexus
Atypical papilloma of choroid plexus (atypical choroid plexus papilloma, aCPP), WHO grade II, ICD-O 9390/1, is a rare intermediate choroid plexus tumor defined by ≥2 mitoses per 10 high-power fields, with higher recurrence risk than grade I papilloma.
Atypical pneumonia
Atypical pneumonia: pneumonia from organisms like Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella, with systemic symptoms, interstitial infiltrates, and beta-lactam resistance; also called walking pneumonia.
Atypical Rett syndrome
Atypical (variant) Rett syndrome: rare genetic neurological disorder requiring regression plus 2 of 4 main and 5 of 11 Rett criteria; linked to MECP2, CDKL5, FOXG1; milder or more severe than classic Rett.
Atypical Rib domain
Atypical Rib domain (aRib), Pfam PF18938, a bacterial cell-surface protein domain related to the Rib domain (PF08428) but lacking the Ig fold; defined by SrpA and GspB adhesin structures, found mainly in Firmicutes.
Atypical teratoid rhabdoid tumor
Atypical teratoid rhabdoid tumor (ATRT, AT/RT) is a rare grade 4 embryonal brain or spinal cord cancer of infants and young children, driven by SMARCB1 or SMARCA4 loss, with TYR, SHH, and MYC molecular subgroups.
Atypical Werner syndrome
Atypical Werner syndrome (AWS): clinically diagnosed Werner syndrome without WRN mutations, usually from heterozygous LMNA mutations; autosomal dominant, onset in the early 20s or earlier, faster progression than classical WS, prevalence under 1 in 1,000,000.
Atypidae
Atypidae, the purseweb spiders, is a mygalomorph spider family with three genera (Atypus, Sphodros, Calommata) and about 54 species; members hunt from an upright silk tube, biting prey through the silk, and form the basal atypoid lineage with Antrodiaetidae and Mecicobothriidae.
Atz Kilcher
Atz Kilcher (Attila Kuno Kilcher) is an American singer-songwriter, Vietnam veteran, and patriarch of Discovery's Alaska: The Last Frontier; oldest son of homesteaders Yule and Ruth Kilcher outside Homer, Alaska, and father of singer Jewel.
Atzompa
Atzompa is a Zapotec archaeological site on El Bonete Hill in Santa María Atzompa, Oaxaca, part of Monte Albán, occupied about 650–900 AD, with three ball courts, two palaces, elite tombs, and a pre-Hispanic pottery kiln.
Au
Au is the chemical symbol for gold, from the Latin aurum, a soft yellow metallic element with atomic number 79 that occurs natively and resists nearly all acids.
Au Bon Pain
Au Bon Pain is a Boston-based fast-casual bakery-café chain founded by Louis Kane and Ron Shaich, whose parent became Panera Bread in 1999; now owned by Ampex Brands with 250+ cafés in hospitals, universities, and airports.
Au Hasard Balthazar
Au hasard Balthazar (1966) is Robert Bresson's French-Swedish drama about a donkey passed between owners in rural France, paralleling Marie (Anne Wiazemsky). Ranked joint 25th in the 2022 Sight & Sound critics' poll; inspired by Dostoevsky's The Idiot.
Au jus
Au jus (French, 'with juice') describes meat, especially roast beef, served with its own thin, unthickened pan juices, or in American usage the sauce itself; unlike gravy it is never thickened with flour or dairy.
Au Lac
Au Lac (Âu Lạc) was an early Vietnamese state founded by Thuc Phan, reigning as An Duong Vuong, with its capital at Co Loa near Hanoi.
AU Mic
HD 197481, better known as AU Microscopii (AU Mic), is a young, nearby red dwarf star in Microscopium with an edge-on debris disk and three known planets.