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Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency

Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency (CHAI disease, CTLA-4 insufficiency) is an autosomal dominant immune dysregulation disorder from heterozygous CTLA4 mutations, causing lymphoproliferation, autoimmunity, hypogammaglobulinemia, and infections with incomplete penetrance.

Autoimmune lymphoproliferative syndrome-recurrent viral infections due to CASP8 deficiency

Autoimmune lymphoproliferative syndrome-recurrent viral infections due to CASP8 deficiency, also called caspase-8 deficiency state, is a rare genetic disorder with lymphadenopathy, splenomegaly, and recurrent herpesvirus infections.

Autoimmune myopathy

Autoimmune myopathy, also called idiopathic inflammatory myopathy, is a group of acquired diseases in which the immune system attacks muscle fibers, causing progressive weakness and elevated muscle enzymes.

Oct 20, 2026

Autoimmune pancreatitis type 2

Autoimmune pancreatitis type 2, also called idiopathic duct-centric pancreatitis, is a rare steroid-responsive inflammation of the pancreas that begins at a younger age than type 1 and is strongly associated with ulcerative colitis.

Autoimmune polyendocrinopathy type 1

Autoimmune polyendocrinopathy type 1, also called APECED, is a rare autosomal recessive autoimmune disorder caused by AIRE gene mutations, typically combining candidiasis, hypoparathyroidism, and adrenal failure.

Autoimmune polyendocrinopathy type 2

Autoimmune polyendocrinopathy type 2 (APS-2, Schmidt syndrome): rare adult-onset autoimmune disorder combining Addison disease with autoimmune thyroid disease and/or type 1 diabetes, polygenic HLA DR3/DR4-associated, female-predominant, prevalence about 1.4–2.0 per 100,000.

Autoimmune polyendocrinopathy type 3

Autoimmune polyendocrinopathy type 3 (APS3, autoimmune polyglandular syndrome type 3, ORPHA:227982): rare multifactorial autoimmune syndrome combining autoimmune thyroid disease with another autoimmune disease such as type 1 diabetes, pernicious anemia, vitiligo, or myasthenia gravis, always excluding Addison disease.

Autoimmune polyendocrinopathy type 4

Autoimmune polyendocrinopathy type 4 (APS-4), also called autoimmune polyglandular syndrome type 4, is an uncommon autoimmune condition attacking one endocrine organ and at least one other organ.

Autoimmune pulmonary alveolar proteinosis

Autoimmune pulmonary alveolar proteinosis (aPAP), formerly idiopathic PAP, is a rare lung disease caused by GM-CSF autoantibodies that block alveolar macrophage surfactant clearance; treated with whole lung lavage and inhaled GM-CSF.

Autoimmune retinopathy

Autoimmune retinopathy (AIR), including cancer-associated retinopathy (CAR), melanoma-associated retinopathy (MAR), and non-paraneoplastic npAIR, is a rare antibody-mediated retinal degeneration causing progressive painless vision loss, diagnosed by ERG changes, antiretinal antibodies, and exclusion of malignancy.

Autoimmune thyroiditis

Autoimmune thyroiditis, chiefly Hashimoto's thyroiditis (chronic lymphocytic thyroiditis), is immune-mediated thyroid destruction causing hypothyroidism; affects about 7.5% of adults, four times more women, treated with levothyroxine.

Autoimmunity

Autoimmunity: immune responses against the body's own tissues, once denied under Ehrlich's horror autotoxicus, accepted in the 1950s; over 80 autoimmune diseases affect 3-5% of people, mostly women, with tolerance failure, environmental triggers, and emerging CAR-T therapies.

Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation

APLAID (autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation), OMIM 614878, is a rare autosomal dominant disease from gain-of-function PLCG2 missense mutations, causing neutrophilic skin lesions, bowel and eye inflammation, antibody deficiency, and G-CSF-driven autoinflammation, without cold urticaria.

Autoland

Autoland (Autolanding) is an aircraft system that lands a plane without pilot control using ILS or GPS guidance, certified for low-visibility Category II and III operations.

Oct 10, 2026

Autoliv

Autoliv, Inc. is a Stockholm-headquartered automotive safety supplier and the world's largest maker of airbags, seatbelts, and steering wheels, holding around 44% of the combined airbag and steering wheel market.

Autologous blood injection

Autologous blood injection (ABI) is a procedure in which a patient's own blood is injected into an injured tendon to stimulate healing, used mainly for tennis elbow.

Autologous blood transfusion

Autologous blood transfusion is the return of a patient's own previously collected blood instead of donor blood, used in cardiac, orthopedic, trauma, and obstetric surgery through techniques such as cell salvage.

Autologous breast reconstruction

Autologous breast reconstruction is a surgical technique that rebuilds the breast after mastectomy using the patient's own tissue, most often a DIEP flap from the abdomen, accounting for about a quarter of US breast reconstructions.

Autologous chondrocyte implantation

Autologous chondrocyte implantation (ACI) is a two-stage cell-based surgery that repairs cartilage defects, chiefly in the knee, first reported in humans by Brittberg and colleagues in 1994.

Autologous cultured chondrocytes on a porcine collagen membrane

MACI (autologous cultured chondrocytes on porcine collagen membrane; matrix-induced autologous chondrocyte implantation) is a Vericel two-stage knee cartilage repair biologic, FDA approved December 13, 2016, for full-thickness cartilage defects in adults.

Autologous fat transfer

Autologous fat transfer, or fat grafting, is a surgical procedure that moves a patient's own fat by liposuction to restore volume in the face, breasts, or buttocks.

Autologous fat transplantation

Autologous fat transplantation, also called fat grafting or lipofilling, is a surgical procedure that moves a patient's own fat to restore volume, most often in the breast and face.

Autologous fecal microbiota transplantation

Autologous fecal microbiota transplantation (auto-FMT) is a procedure in which a patient's own stool, banked before treatment, is reinfused to restore gut microbiota after antibiotics or chemotherapy.

Autolus Therapeutics plc

Autolus Therapeutics plc is a London-based, Nasdaq-listed biopharmaceutical company spun out of University College London in 2014; its CAR T therapy AUCATZYL, for adult leukemia, won FDA approval in November 2024.

Autolysis

Autolysis (GO:0001896) is programmed cell death by lysis in bacteria and filamentous fungi, mediated by autolysins; seen in Bacillus subtilis sporulation, Streptococcus pneumoniae transformation, biofilms, and engineered autolytic bacteria.

Autolysis (biology)

Autolysis is the spontaneous self-digestion of cells or tissues by their own enzymes, chiefly leaked lysosomal hydrolases after death. Also called postmortem autolysis; distinct from necrosis and apoptosis; exploited industrially in yeast extract production.

Automan

Automan is a 1983-1984 American ABC science fiction superhero series created by Glen A. Larson, starring Desi Arnaz Jr. as programmer Walter Nebicher and Chuck Wagner as his holographic crime-fighting alter ego Otto J. Mann, cancelled after 13 episodes.