edgepedia

Small-molecule and chemical drug developers

317 articles

CensBio (赛神医药)

SciNeuro Pharmaceuticals (赛神医药), registered as 赛神(上海)医药科技有限公司, is a clinical-stage biotech company founded in Shanghai in 2020 by Dr. Min Li, developing treatments for Alzheimer's and Parkinson's disease.

Centrexion Therapeutics Corp

Centrexion Therapeutics Corp is a Boston-based biopharmaceutical company founded in 2013 that develops non-opioid, non-addictive therapies for chronic pain, led by former Pfizer CEO Jeffrey Kindler.

Cerecin Inc.

Cerecin Inc, formerly Accera Inc, is a private clinical-stage biotech headquartered in Denver and Singapore, developing ketogenic drugs for neurological disorders; Nestlé holds a 60 percent stake.

CF PharmTech (长风药业)

CF PharmTech (长风药业) is a Chinese developer of inhaled respiratory drugs for asthma and COPD, headquartered in Suzhou and listed in Hong Kong in 2025.

Checkmate Pharmaceuticals

Checkmate Pharmaceuticals was a clinical-stage immuno-oncology company in Cambridge, Massachusetts, founded in 2015, whose drug vidutolimod was acquired by Regeneron in 2022 for about $250 million.

Chengdu New Radiomedicine Technology (纽瑞特医疗)

Chengdu New Radiomedicine Technology (纽瑞特医疗) is a Chinese radiopharmaceutical and medical-isotope company founded in Chengdu in 2016, whose lead drug NRT6003 treats liver cancer.

Chinook Therapeutics

Chinook Therapeutics was a clinical-stage biopharmaceutical company developing precision medicines for severe kidney diseases, incubated in Vancouver and acquired by Novartis in 2023 for up to $3.5 billion.

CinCor Pharma

CinCor Pharma was a Cincinnati-based clinical-stage biopharmaceutical company, founded in 2018, that developed the hypertension drug baxdrostat and was acquired by AstraZeneca in 2023 for up to $1.8 billion.

Circle Pharma

Circle Pharma is a clinical-stage biopharmaceutical company in South San Francisco, California, developing oral macrocycle drugs for cancer, with lead program CID-078 in Phase 1 testing.

Concentric Analgesics

Concentric Analgesics is a private San Francisco biotechnology company, founded in 2014, developing non-opioid pain therapeutics based on TRPV1 agonist prodrugs such as vocacapsaicin, its lead post-surgical pain candidate.

Constellation Pharmaceuticals, Inc.

Constellation Pharmaceuticals was a Cambridge, Massachusetts biopharmaceutical company that used epigenetics to develop cancer therapeutics, including pelabresib, and was acquired by MorphoSys in 2021 for $1.7 billion.

CoreStone Bio

CoreStone Bio (晶核生物) is a clinical-stage Chinese biotechnology company founded in Shanghai in 2021 that develops image-guided targeted radionuclide therapy drugs for cancer, with a PSMA-targeted lead program in Phase I/II trials.

Corxel Pharmaceuticals (箕星药业)

Corxel Pharmaceuticals (箕星药业), known until 2026 as Ji Xing Pharmaceuticals, is a Shanghai-based clinical-stage biopharmaceutical company founded in 2019 that develops oral GLP-1, stroke, and hypertension drugs.

Coultreon Biopharma

Coultreon Biopharma, formerly Onco3R Therapeutics, is a Leuven, Belgium biotechnology company spun out of Galapagos NV in 2025, developing an oral SIK3 inhibitor for autoimmune diseases.

Cyclerion Therapeutics, Inc.

Cyclerion Therapeutics is a clinical-stage biopharmaceutical company in Cambridge, Massachusetts, spun off from Ironwood Pharmaceuticals in 2019 to develop soluble guanylate cyclase stimulators; it sold its zagociguat assets in 2023 and relaunched as a neuropsychiatric company.

Cyteir Therapeutics, Inc.

Cyteir Therapeutics was a clinical-stage biotechnology company in Lexington, Massachusetts, developing precision oncology medicines targeting DNA damage repair; it went public on Nasdaq in 2021 and announced its dissolution in 2023.

D3 Bio (德升济医药)

D3 Bio (德升济医药) is a clinical-stage Chinese biotechnology company founded in 2020 in Wuxi that develops small-molecule and antibody cancer drugs, led by founder and CEO Chen Zhijian.

Day One Biopharmaceuticals

Day One Biopharmaceuticals was a South San Francisco biopharmaceutical company that developed tovorafenib (OJEMDA), an FDA-approved treatment for relapsed pediatric low-grade glioma, before being acquired by Servier in 2026.

Deciphera Pharmaceuticals

Deciphera Pharmaceuticals was a Waltham, Massachusetts biopharmaceutical company founded in 2003 by Daniel L. Flynn that developed kinase switch-control inhibitors for cancer; its drug QINLOCK treats advanced gastrointestinal stromal tumor.

DermBiont, Inc.

DermBiont, Inc. is a Boston-based clinical-stage biotechnology company developing targeted topical small-molecule therapeutics for skin diseases, with lead candidates SM-020 for seborrheic keratoses and SM-030 for melasma.

Design Therapeutics

Design Therapeutics is a clinical-stage biopharmaceutical company in Carlsbad, California, founded in 2017 by Pratik Shah and Aseem Ansari to develop GeneTAC small molecules targeting inherited repeat expansion disorders.

Dewpoint Therapeutics

Dewpoint Therapeutics is a Boston-based biotechnology company co-founded in 2018 by Anthony Hyman and Richard Young that develops condensate-modulating small molecules, entering the clinic in 2025 with DPTX3186 for gastric cancer.

DiCE Molecules

DiCE Molecules, renamed DICE Therapeutics in 2021, was a South San Francisco biotech that used DNA-encoded libraries to discover oral small molecules before Eli Lilly acquired it in 2023.

Doma Pharma

Doma Pharma (多玛医药) is a Suzhou-based biotechnology company that operates as a life-sciences incubator and drug developer. It raised RMB 950 million in a 2022 Series A.

DrugAI (Hangzhou Derui Zhiyao)

DrugAI, also known as MindRank (德睿智药), is a Chinese AI drug-discovery startup in Hangzhou whose oral GLP-1 weight-loss drug MDR-001 became China's first AI-designed small-molecule new drug to reach Phase III trials.

EdenRoc Sciences

EdenRoc Sciences, also known as EdenRoc Sciences LLC, is a life sciences holding company founded in 2016 in Worcester, Massachusetts, focused on diseases of aging through subsidiaries in pharmaceuticals, genomics, and forensics.

Edgewise Therapeutics

Edgewise Therapeutics is a clinical-stage biopharmaceutical company, founded in 2017, that develops small molecule drugs targeting the sarcomere, first for muscular dystrophies and since 2026 for cardiovascular disease.

eFFECTOR Therapeutics

eFFECTOR Therapeutics was a clinical-stage biopharmaceutical company in Solana Beach, California, founded in 2012, whose cancer drugs tomivosertib and zotatifin failed to save it from winding down in 2024.

Elevara Medicines

Elevara Medicines is a London-based clinical-stage biotechnology company developing ELV001, an oral CDK4/6 inhibitor licensed from Japan's Teijin Pharma, as a therapy for rheumatoid arthritis.

Emalex Biosciences

Emalex Biosciences was a Chicago biotechnology company founded in 2018 to develop treatments for central nervous system disorders, best known for the Tourette syndrome drug ecopipam.