# Poison dart frog
**Poison dart frog** is the common name for the frogs of the family **Dendrobatidae** (Cope, 1865), a group of small, often brightly colored, diurnal frogs native to Central and South America whose skin carries toxic alkaloids taken up from their diet. They are also called poison frogs, poison arrow frogs, and dart-poison frogs.[1](https://amphibiansoftheworld.amnh.org/Amphibia/Anura/Dendrobatoidea/Dendrobatidae) • [2](https://nationalzoo.si.edu/animals/poison-frogs)
| Key fact | Detail |
|---|---|
| Species count | 213 recognized species in the family Dendrobatidae (Amphibian Species of the World 6.2)[1](https://amphibiansoftheworld.amnh.org/Amphibia/Anura/Dendrobatoidea/Dendrobatidae) |
| Distribution | Nicaragua to the Amazon Basin of Bolivia and to the Guianas and southeastern Brazil[1](https://amphibiansoftheworld.amnh.org/Amphibia/Anura/Dendrobatoidea/Dendrobatidae) |
| Size | Generally small, about 0.75 to 1.5 inches (20 to 40 millimeters) in length[2](https://nationalzoo.si.edu/animals/poison-frogs) |
| Toxicity source | Skin alkaloids are sequestered from a diet of leaf-litter arthropods; captive-raised frogs on non-poisonous insects are not poisonous[2](https://nationalzoo.si.edu/animals/poison-frogs) • [3](https://pubmed.ncbi.nlm.nih.gov/7940573/) |
| Dart use | Only three species, all in the genus *Phyllobates*, have been documented as actually used to poison arrow or dart tips; the golden poison frog, which secretes batrachotoxin, is the most toxic of all frog species[2](https://nationalzoo.si.edu/animals/poison-frogs) |
| Parental care | Tadpole transport by males is the ancestral condition (132 species); female transport has appeared at least five times[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC8463664/) |
| Lifespan | Over ten years in human care; the tri-colored poison frog lives 12 to 20 years[2](https://nationalzoo.si.edu/animals/poison-frogs) |
| Split from relatives | Dendrobatidae diverged from its sister family Aromobatidae about 36 ± 10 million years ago[5](https://www.mdpi.com/1424-2818/11/8/126) |
## Classification and systematics
Dendrobatidae sits within the superfamily Dendrobatoidea, a rank elevated in the 2006 revision by Grant, Frost, Caldwell, Gagliardo, Haddad, Kok, Means, Noonan, Schargel, and Wheeler. That revision placed Dendrobatidae (sensu lato) as the sister taxon of [Hylodidae](https://www.edgepedia.org/hylodidae) and partitioned the former family into two families, Aromobatidae and Dendrobatidae, with only the latter bearing poisonous skin alkaloids, and provided a new arrangement of monophyletic subfamilies and genera.[6](https://doi.org/10.1206/0003-0090%282006%29299%5B1%3Apsodfa%5D2.0.co%3B2) • [1](https://amphibiansoftheworld.amnh.org/Amphibia/Anura/Dendrobatoidea/Dendrobatidae) The family name Dendrobatidae Cope, 1865 has been given precedence over the older name Phyllobatae Fitzinger, 1843 whenever the two are considered synonyms, by a 2009 decision of the International Commission on Zoological Nomenclature.[1](https://amphibiansoftheworld.amnh.org/Amphibia/Anura/Dendrobatoidea/Dendrobatidae)
The higher-level relationships of the group were debated for decades, with authors variously placing dendrobatids within [Ranidae](https://www.edgepedia.org/ranidae), near Hylodinae, or within hylid lineages based on morphology and early DNA sequences.[1](https://amphibiansoftheworld.amnh.org/Amphibia/Anura/Dendrobatoidea/Dendrobatidae) A 2000 study using mitochondrial DNA showed that, relative to *Minyobates*, the genus *Dendrobates* does not include all of its descendants, while the closest relative of every other poisonous species is *[Allobates](https://www.edgepedia.org/allobates)*.[7](https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1095-8312.2000.tb01236.x) A time-calibrated phylogeny published in 2009 from about 2,400 base pairs of mitochondrial data, and later phylogenomic work using ultraconserved elements, have continued to refine the family tree.[5](https://www.mdpi.com/1424-2818/11/8/126) New species are still being described; a 2024 molecular study added two new species to the genus *Phyllobates*, and a 2026 revision of the *Ameerega bassleri* group described a new species from Peru.[8](https://zookeys.pensoft.net/article/126733/download/pdf/) • [9](https://doi.org/10.11646/zootaxa.5759.3.4)
## Toxicity and its dietary origin
Poison frogs sequester chemical defenses from their diet of leaf-litter arthropods. The dietary hypothesis arose when it was noticed that poison frogs reared in captivity lacked alkaloids; wild-caught frogs keep their alkaloids for years in captivity, but the toxins are not present in captive-raised frogs, and frogs in zoos fed crickets and other non-poisonous insects are not poisonous.[3](https://pubmed.ncbi.nlm.nih.gov/7940573/) • [2](https://nationalzoo.si.edu/animals/poison-frogs) The insects themselves most likely acquire the toxins from their plant diet.[2](https://nationalzoo.si.edu/animals/poison-frogs)
Sequestration evolved more than once. Poison frogs of Dendrobatidae have evolved the ability to acquire alkaloids from their diet for chemical defense at least three times, and recent data show that species from each undefended poison frog clade carry measurable but low amounts of alkaloids, supporting a phenotypic intermediate called passive accumulation, which involves no derived transport and storage mechanisms yet results in low toxin levels.[10](https://pubmed.ncbi.nlm.nih.gov/39728927/) Feeding experiments show the process is fast: frogs fed the alkaloid decahydroquinoline, which they naturally sequester in the wild, took it up rapidly, meaning acute shifts in arthropod diet could quickly change a frog's chemical repertoire and its palatability to predators.[11](https://pmc.ncbi.nlm.nih.gov/articles/PMC7888741/)
The best-studied toxin is epibatidine, isolated from the Ecuadorian frog *Epipedobates tricolor*. The biochemist John William Daly collected 750 frogs in 1974 to obtain 80 milligrams of skin mucus and managed to isolate only 0.5 milligrams of epibatidine, enough to detect the molecule but not to determine its structure; nuclear magnetic resonance advances in the early 1990s revealed it in 1992 as a small alkaloid of 11 carbon, 13 hydrogen, two nitrogen, and one chlorine atoms, structurally similar to nicotine.[12](https://www.lemonde.fr/en/science/article/2026/04/19/from-a-south-american-frog-to-a-russian-penal-colony-how-the-poison-epibatidine-killed-navalny_6752595_10.html) The frogs do not produce the molecule themselves; they retain it from their food, most likely ants or small arthropods, and possibly bacteria in those insects make the toxin.[12](https://www.lemonde.fr/en/science/article/2026/04/19/from-a-south-american-frog-to-a-russian-penal-colony-how-the-poison-epibatidine-killed-navalny_6752595_10.html) Once ingested, epibatidine is believed to cross the buccal mucosa and intestinal barrier into the bloodstream, where a liver-produced protein, the alkaloid-binding globulin, acts as a toxin sponge that protects the frog from its own toxicity and carries the poison to secretory glands at the back of the head.[12](https://www.lemonde.fr/en/science/article/2026/04/19/from-a-south-american-frog-to-a-russian-penal-colony-how-the-poison-epibatidine-killed-navalny_6752595_10.html) The toxins serve the frog as a predator repellent together with its skin colors, and as a defense against pathogenic bacteria on the skin surface.[12](https://www.lemonde.fr/en/science/article/2026/04/19/from-a-south-american-frog-to-a-russian-penal-colony-how-the-poison-epibatidine-killed-navalny_6752595_10.html)
## Coloration and the dart-poison name
Poison frogs are known for bright warning colors, typically red, orange, or yellow. Such aposematic coloration is theorized to function as a visual warning that predators learn: a predator that finds an amphibian distasteful associates the color with the bad taste and refrains from attacking after one or more experiences. Some animals carry bright coloration that does not correlate with toxicity, presumably mimicking the genuinely warning-colored ones.[2](https://nationalzoo.si.edu/animals/poison-frogs)
The name poison dart frog comes from reports that indigenous communities rubbed arrow tips on the frogs' backs before hunting. However, only three species have actually been documented being used for this purpose, all in the genus *Phyllobates* rather than the more familiar brightly colored *Dendrobates*; the [golden poison frog](https://www.edgepedia.org/golden-poison-frog), the most toxic of all frog species, secretes the alkaloid batrachotoxin, which interests medical researchers developing muscle relaxants, heart stimulants, and anesthetics.[2](https://nationalzoo.si.edu/animals/poison-frogs)
## Reproduction and parental care
In wet tropical rainforests both sexes breed throughout the year, with rainfall the primary factor controlling reproductive timing. Courtship can last several hours, with the pair visiting several deposition sites and performing a mating dance of mutual stroking and cleaning of leaf surfaces. Clutch size varies from one to 40 eggs; after about ten to 18 days the eggs hatch into tadpoles, and all poison frog species carry their tadpoles on their backs to a small stream, pool, or other small body of water.[2](https://nationalzoo.si.edu/animals/poison-frogs)
**Care is divided unevenly between the sexes.** Across dendrobatids, males are the caregiver in most cases (92 species), and ancestral reconstructions support male care as the ancestral condition; female care (10 species) evolved independently at least twice. Tadpole transport by males (132 species) is the ancestral state, while transport by females (17 species) has appeared at least five times, in *Dendrobates* (subgenus *Oophaga*), *Allobates*, *Hyloxalus*, *Colostethus*, and *Mannophryne*.[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC8463664/) Transporting parents in some dendrobatids distribute their offspring across a variety of pools to increase the probability of offspring survival, a bet-hedging strategy.[13](https://phaidra.vetmeduni.ac.at/detail/o%3A3607.pdf)
Some species use tiny water bodies such as bromeliad axils, tree-holes, and palm bracts (phytotelmata), where large predators are rare but nutritional resources are scarce. Females of some species place individual tadpoles in water in bromeliads and then periodically return to deposit unfertilized eggs, which the tadpoles eat.[2](https://nationalzoo.si.edu/animals/poison-frogs) • [4](https://pmc.ncbi.nlm.nih.gov/articles/PMC8463664/) Most species have omnivorous tadpoles that eat algae, detritus, insect larvae, and dead insects; some, such as the tri-colored poison frog, are more carnivorous and eat insect larvae and other tadpoles.[2](https://nationalzoo.si.edu/animals/poison-frogs)
## Conservation
[Habitat destruction](https://www.edgepedia.org/habitat-destruction), collection for the pet trade, and the chytrid fungus all affect poison frogs. Rainforest destruction by fire and for farmland has contributed to decreasing wild numbers, and the illegal pet trade has also affected their existence.[2](https://nationalzoo.si.edu/animals/poison-frogs) Trade is substantial: approximately 62,000 specimens of the green and black poison frog (*Dendrobates auratus*) were reported in the pet trade between 1978 and 2008, raising concern that over-harvesting of rarer morphs could contribute to localized declines given the species' apparently low fecundity.[14](https://doi.org/10.2305/IUCN.UK.2020-2.RLTS.T55174A3024941.en) For the strawberry poison frog (*Oophaga pumilio*), [Nicaragua](https://www.edgepedia.org/nicaragua) was the largest exporter between 1991 and 1996 (over 95 percent of exports), and the species makes up 7 percent of all CITES amphibian trade.[15](https://doi.org/10.2305/IUCN.UK.2015-4.RLTS.T55196A3025630.en)
Some species are highly restricted. The last remaining *Epipedobates tricolor* frogs in Ecuador are scattered across just over 6,800 square kilometers of continuously declining habitat; the species was classified as vulnerable and added to the IUCN Red List in 2019.[12](https://www.lemonde.fr/en/science/article/2026/04/19/from-a-south-american-frog-to-a-russian-penal-colony-how-the-poison-epibatidine-killed-navalny_6752595_10.html) Reserves created for specific species can succeed: in Colombia, the Ranita Dorada Amphibian Reserve was set up to safeguard the two poison-dart frog species *Andinobates dorisswansonae* and *Andinobates tolimense*, and their situation has since gotten better to the point that no longer does either meet the criteria as an Alliance for Zero Extinction trigger species.[16](https://iucn.org/news/species/201811/last-refuges-endangered-species-mapped-showing-nearly-half-lack-protection)
## References
1. [Dendrobatidae Cope, 1865 (1850), Amphibian Species of the World 6.2, American Museum of Natural History](https://amphibiansoftheworld.amnh.org/Amphibia/Anura/Dendrobatoidea/Dendrobatidae)
2. [Poison frogs, Smithsonian's National Zoo and Conservation Biology Institute](https://nationalzoo.si.edu/animals/poison-frogs)
3. [An uptake system for dietary alkaloids in poison frogs (Dendrobatidae), Toxicon](https://pubmed.ncbi.nlm.nih.gov/7940573/)
4. [Aposematism facilitates the diversification of parental care strategies in poison frogs, PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8463664/)
5. [Phylogenomic Reconstruction of the Neotropical Poison Frogs (Dendrobatidae) and Their Conservation, Diversity 11(8):126](https://www.mdpi.com/1424-2818/11/8/126)
6. [Grant et al. (2006). Phylogenetic systematics of dart-poison frogs and their relatives (Amphibia: Athesphatanura: Dendrobatidae). Bulletin of the American Museum of Natural History 299](https://doi.org/10.1206/0003-0090%282006%29299%5B1%3Apsodfa%5D2.0.co%3B2)
7. [Clough & Summers (2000). Phylogenetic systematics and biogeography of the poison frogs: evidence from mitochondrial DNA sequences. Biological Journal of the Linnean Society](https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1095-8312.2000.tb01236.x)
8. [Amézquita et al. (2024). Molecular phylogenetics uncovers two new species in the genus Phyllobates (Anura, Dendrobatidae). ZooKeys 1212](https://zookeys.pensoft.net/article/126733/download/pdf/)
9. [Geralds et al. (2026). A revision of the Ameerega bassleri species group (Anura: Dendrobatidae) and a new species from Peru. Zootaxa 5759](https://doi.org/10.11646/zootaxa.5759.3.4)
10. [Passive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses](https://pubmed.ncbi.nlm.nih.gov/39728927/)
11. [Rapid toxin sequestration modifies poison frog physiology, Journal of Experimental Biology / PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC7888741/)
12. [From a South American frog to a Russian penal colony: How the poison epibatidine killed Navalny, Le Monde](https://www.lemonde.fr/en/science/article/2026/04/19/from-a-south-american-frog-to-a-russian-penal-colony-how-the-poison-epibatidine-killed-navalny_6752595_10.html)
13. [What Amphibians Can Teach Us About the Evolution of Parental Care, University of Veterinary Medicine Vienna](https://phaidra.vetmeduni.ac.at/detail/o%3A3607.pdf)
14. [Dendrobates auratus (Green and Black Poison Frog), The IUCN Red List of Threatened Species](https://doi.org/10.2305/IUCN.UK.2020-2.RLTS.T55174A3024941.en)
15. [Oophaga pumilio (Strawberry Poison Frog), The IUCN Red List of Threatened Species](https://doi.org/10.2305/IUCN.UK.2015-4.RLTS.T55196A3025630.en)
16. [Last refuges of endangered species mapped, showing nearly half lack protection, IUCN](https://iucn.org/news/species/201811/last-refuges-endangered-species-mapped-showing-nearly-half-lack-protection)
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*Topic: Encyclopedia › Life and health › Animals › Vertebrates › Reptiles and amphibians › Amphibians › Frogs and toads (Anura) › Poison dart frogs (Dendrobatidae) › Dendrobatidae overview and systematics*
*Initially written Sep 17, 2026 · Reviewed: Sep 30, 2026; Oct 21, 2026 · Edited: Sep 30, 2026; Oct 21, 2026 · Last review: Oct 21, 2026*
*Copyright 2026 EdgeChat AI, a subsidiary of Biostate AI.*
License: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license