All articles starting with D
24,034 articles
Design technology co-optimization
Design technology co-optimization (DTCO) is a semiconductor methodology that jointly optimizes a manufacturing process, its design rules, and design enablement, replacing the traditional one-way handoff to designers.
Design Therapeutics
Design Therapeutics is a clinical-stage biopharmaceutical company in Carlsbad, California, founded in 2017 by Pratik Shah and Aseem Ansari to develop GeneTAC small molecules targeting inherited repeat expansion disorders.
Design thinking
Design thinking is a human-centered, iterative approach to innovation that begins from people's needs rather than fixed specifications, popularized by IDEO and Stanford's d.school through stages like empathize and prototype.
Design-based inference
Design-based inference is a framework for statistical inference in which uncertainty is quantified through the randomization used to select samples, not through assumed models, tracing to Jerzy Neyman's 1934 paper.
Design-based research
Design-based research (DBR), a methodology from the learning sciences, studies learning in real classrooms through iterative cycles of design, enactment, analysis, and redesign, aiming to improve practice and build theory.
Design-basis accident
A design-basis accident (DBA) is a postulated accident a nuclear facility is designed to withstand through conservative analysis, with radioactive releases kept within acceptable limits and no significant radiological consequences.
Design–bid–build
Design–bid–build, or DBB, is a construction project delivery method where design and construction are sequential and contracted separately, the traditional method for US public works.
Design–build
Design–build, or design and build, is a project delivery method in which a single entity holds one contract with the owner for both design and construction.
Design–build–finance–operate
Design–build–finance–operate (DBFO) is a public–private partnership structure in which a private party designs, builds, finances, and operates a capital project while government retains ownership, first used on UK roads in 1996.
DesignArena
DesignArena is a crowdsourced benchmarking platform built by Arcada Labs, a Y Combinator Summer 2025 startup, that runs blind voting tournaments ranking AI models on website, image, and video generation and app-building agents.
Designated driver
A designated driver is a member of a drinking group who stays sober and drives the others home safely, a concept popularized in the United States in 1988.
Designated for assignment
Designated for assignment (DFA): MLB transaction removing a player from the 40-man roster, starting a seven-day window to trade, waive, outright, or release him; pay continues, veterans can refuse outright assignments.
Designated hitter
Designated hitter (DH), baseball rule letting a specialist bat for the pitcher; adopted by the AL in 1973 (Ron Blomberg first), universal in MLB since 2022, Central League Japan 2027.
Designated marksman rifle
A designated marksman rifle (DMR) is a scoped, semi-automatic rifle issued to an infantry squad's designated marksman to engage point targets at 300 to 600 meters.
Designated Pilot Examiner
A Designated Pilot Examiner (DPE) is a private individual, not an FAA employee, appointed by the FAA to conduct pilot certificate and rating practical tests, roughly 124,000 in fiscal 2024.
Designated Player Rule
Designated Player Rule (Beckham Rule): MLS roster rule letting each club sign up to three players above the Maximum Salary Budget Charge ($803,125 in 2026), created in 2006 for David Beckham's LA Galaxy signing.
Designated survivor
Designated survivor: the U.S. official in the presidential line of succession who skips the State of the Union and similar gatherings, staying at a secure location to assume the presidency if an attack kills the leadership present. Cold War-era practice, first acknowledged in 1981.
Designated Survivor (TV series)
Designated Survivor is an American political thriller (2016–2019) starring Kiefer Sutherland as Tom Kirkman, a HUD secretary who becomes president after a State of the Union attack; two ABC seasons, one Netflix season.
Designated Survivor: 60 Days
Designated Survivor: 60 Days (60일, 지정생존자) is a 2019 tvN South Korean remake of the American series Designated Survivor: after a National Assembly bombing kills the succession line, Environment Minister Park Mu-jin (Ji Jin-hee) serves 60 days as acting president. 16 episodes, Studio Dragon/eOne, AACA Best Adaptation winner.
Designation of workers by collar color
Designation of workers by collar color is an informal way of classifying jobs as white-collar office work, blue-collar manual work, and newer colors like pink and gray.
Designed protein 2D lattices
Designed protein 2D lattices are planar, periodically ordered arrays of protein building blocks assembled with a prescribed geometry, either through engineered protein-protein interfaces or DNA origami scaffolds.
Designed protein nanocages
Designed protein nanocages, also called nanohedra, are artificial proteins that self-assemble into hollow geometric shells, engineered computationally or from natural cages for vaccines and drug delivery.
Designer
A designer is a professional working in a recognized design specialism such as industrial, graphic, or UX design, an occupation now spread across the whole economy rather than only dedicated design firms.
Designer baby
Designer baby: a baby whose genes are selected or altered before birth, via IVF embryo testing (PGT-M, polygenic scores) or CRISPR editing; first PGT births 1990, He Jiankui's 2018 CCR5-edited twins, widely restricted by law.
Designer drug
A designer drug is a synthetic psychoactive substance made by slightly modifying a controlled drug so it mimics the original's effects while evading existing legal controls.
Designing Data-Intensive Applications
Designing Data-Intensive Applications (DDIA) is Martin Kleppmann's 2017 O'Reilly book on database internals, replication, partitioning, transactions, consensus, and batch and stream processing; a second edition with Chris Riccomini appeared in February 2026.
Designing Woman
Designing Woman is a 1957 MGM romantic comedy directed by Vincente Minnelli, starring Gregory Peck and Lauren Bacall as a sportswriter and fashion designer in a whirlwind marriage; it won George Wells the 1958 Oscar for Best Original Screenplay.
Designing Women
Designing Women: American CBS sitcom created by Linda Bloodworth-Thomason, 1986-1993, 163 episodes, set at the Atlanta interior design firm Sugarbaker & Associates with Dixie Carter, Delta Burke, Annie Potts, Jean Smart, and Meshach Taylor; known for feminist social-issue comedy.
Designit
Designit is a global strategic design and innovation consultancy founded in 1991 in Aarhus, Denmark, and owned since 2015 by the Indian IT company Wipro.
Desiigner
Desiigner (Sidney Royel Selby III, born 1997, Brooklyn) is the rapper behind "Panda", a 2016 Hot 100 number one, triple platinum, sampled by Kanye West; G.O.O.D. Music 2016–2019, then independent.