All articles starting with E
17,681 articles
Epidermolysis bullosa simplex with mottled pigmentation
Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP, OMIM 131960) is a rare autosomal dominant KRT5-related skin-fragility disorder with neonatal blistering, later reticulate hyperpigmentation that fades in adulthood, keratoderma, and nail dystrophy.
Epidermolysis bullosa simplex with muscular dystrophy
Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD, OMIM 226670) is a rare autosomal recessive plectinopathy caused by PLEC mutations, featuring neonatal skin blistering, nail dystrophy, and later-onset progressive muscular dystrophy.
Epidermolysis bullosa simplex with pyloric atresia
Epidermolysis bullosa simplex with pyloric atresia (EBS-PA, OMIM 612138) is a rare autosomal recessive skin-fragility disorder with congenital pyloric atresia, caused by PLEC, ITGB4, or ITGA6 mutations and usually fatal in infancy.
Epidermolytic nevus
Epidermolytic nevus (epidermal nevus with epidermolytic hyperkeratosis) is a rare mosaic birth defect: verrucous Blaschko-linear skin lesions with EHK histology, no extracutaneous involvement, and risk of transmitting bullous ichthyosiform erythroderma.
Epidermolytic palmoplantar keratoderma
Epidermolytic palmoplantar keratoderma (EPPK, Vörner's keratosis, OMIM 144200) is a rare autosomal dominant skin disease causing yellow thickening of palms and soles with erythematous borders, caused mostly by KRT9 mutations.
Epidermophyton
Epidermophyton (Sabour., 1907) is a dermatophyte fungus genus in Arthrodermataceae with one accepted species, E. floccosum, an anthropophilic cause of tinea cruris and tinea pedis; ITS analysis keeps it a separate genus, β-tubulin places it in Nannizzia.
Epididymis
Epididymis: convoluted duct connecting testis to vas deferens, with initial segment, caput, corpus, and cauda regions; site of mammalian sperm maturation, concentration, protection, and storage via epididymosomes.
Epididymitis
Epididymitis, inflammation of the epididymis behind the testicle, acute (<6 weeks) or chronic; caused by chlamydia, gonorrhea, or E. coli; treated with ceftriaxone plus doxycycline or levofloxacin; torsion is the key differential.
Epidural administration
Epidural administration injects local anesthetics or opioids into the epidural space between dura mater and vertebral canal. Pioneered by Corning (1885), Sicard and Cathelin (1901), and Fidel Pagés (1921); used for labor, surgery, and postoperative pain.
Epidural Blood Patch
Epidural blood patch (EBP): injection of a patient's own blood, typically 10–20 mL, into the epidural space to seal dural punctures and CSF leaks; first reported by Gormley in 1960; treats post-dural puncture headache and spontaneous intracranial hypotension.
Epidural hematoma
Epidural hematoma (EDH, extradural hematoma): blood between skull and dura, usually from middle meningeal artery tear after skull fracture. Biconvex on CT, lucid interval in under 20%, surgery if over 30 cm3 per Brain Trauma Foundation.
Epidural steroid injection
An epidural steroid injection delivers a corticosteroid, often with local anesthetic, into the epidural space around spinal nerves to relieve radicular pain from disc herniation and spinal stenosis.
Epifany Slavinetsky
Epifany Slavinetsky (Епифаний Славинецкий) was a hieromonk, philologist, and translator summoned to Moscow in 1649 to correct the Church Slavonic Bible from the Greek text.
Epigallocatechin
Epigallocatechin (EGC) is a flavan-3-ol catechin polyphenol with six hydroxyl groups and the formula C15H14O7, the second predominant catechin in green tea, first isolated in 1948.
Epigallocatechin gallate
Epigallocatechin gallate (EGCG), (−)-epigallocatechin-3-gallate, is the major catechin polyphenol of green tea (Camellia sinensis), isolated in 1948; known for poor bioavailability, anti-inflammatory and anticancer research, and liver-toxicity limits above 800 mg/day.
Epigastric hernia
Epigastric hernia: a ventral hernia through the linea alba between the xiphoid process and umbilicus, usually containing preperitoneal fat, 2-3 times more common in men, repaired surgically, often with mesh.
Epigastrium
Epigastrium (regio epigastrica): the upper central abdominal region below the sternum, above the umbilicus, flanked by the hypochondriac regions. Contains stomach, liver, pancreas, duodenum; epigastric pain (ICD-10 R10.13) has a broad differential including cardiac causes.
Epigenetic clock
An epigenetic clock is a biomarker method estimating biological age from DNA methylation patterns, used in aging research to assess disease risk and aging rate.
Epigenetic regulation of gene expression
Epigenetic regulation of gene expression: heritable control of transcription without DNA sequence change, via DNA methylation (DNMTs, TETs), histone modification, Polycomb complexes, and noncoding RNA.
Epigenetic therapy
Epigenetic therapy is a class of cancer treatment that uses drugs such as azacitidine and decitabine to reverse abnormal DNA methylation and histone modifications, reprogramming tumor cells rather than killing them.
Epigenetics
Epigenetics (epigenomics) is the study of gene-activity changes without DNA sequence alteration, via DNA methylation, histone modification, and non-coding RNAs; the term was coined by Waddington, and transgenerational inheritance in mammals remains debated.
Epigenome
The epigenome is the set of chemical modifications to DNA and DNA-associated proteins that alter gene expression without changing the DNA sequence, and many marks are heritable when cells divide.
Epigenome editing
Epigenome editing, also known as epigenetic editing or epigenome engineering, is a genome engineering method that alters gene expression without making DNA breaks, first demonstrated in 2002.
Epigenomics
Epigenomics is the genome-wide study of epigenetic changes, such as DNA methylation and histone modification, aiming to map regulatory elements and understand disease mechanisms and cell types.
Epigeus (crater on Ganymede)
Epigeus is a 343-km-diameter palimpsest impact crater on Jupiter's moon Ganymede, centered at 22.96°N, 180.65°W in the Nippur Sulcus region; IAU-named in 1997 for a Phoenician god.
Epiglottis
The epiglottis, or epiglottic cartilage, is a leaf-shaped flap of elastic cartilage behind the tongue that folds over the windpipe during swallowing, its infection called epiglottitis.
Epiglottitis
Acute epiglottitis (supraglottitis): rapidly progressive bacterial infection of the epiglottis causing airway obstruction. Once mainly Hib in children, now mostly adult disease; treated with airway protection, ceftriaxone, steroids.
Epigonii
Epigonii is a poem by Mihai Eminescu, first published in 1870 as an ars poetica contrasting the sincere writers of the past with his own cold generation.
Epigonus telescopus
Epigonus telescopus (Risso, 1810), the black cardinal fish or telescope cardinal, is a deepwater cardinalfish (Epigonidae) of temperate Atlantic, Indian, and Southwest Pacific slopes, reaching 75 cm, living 104 years, at 75–1,305 m, IUCN Least Concern.
Epigram
Epigram: a short, pointed, often witty poem, from Greek epigramma (inscription). Began as 8th-century BCE Greek verse inscriptions, became a Hellenistic literary genre, shaped by Martial, and flourished in Renaissance England.