All articles starting with G
18,970 articles
Glucose-6-phosphatase
Glucose-6-phosphatase (G6Pase, EC 3.1.3.9; subunits G6PC1, G6PC2, G6PC3) is an ER enzyme complex hydrolyzing glucose-6-phosphate to glucose and phosphate, the final step of glycogenolysis and gluconeogenesis; defects cause glycogen storage disease type I.
Glucose-6-phosphate dehydrogenase
Glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49), first and rate-limiting enzyme of the oxidative pentose phosphate pathway producing NADPH; X-linked; deficiency affects over 400 million people and risks hemolysis with primaquine, fava beans, and oxidizing drugs.
Glucose-6-phosphate dehydrogenase deficiency
Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency, G6PDD) is an X-linked genetic enzyme disorder affecting about 400 million people, causing hemolytic anemia triggered by infections, fava beans, and drugs such as primaquine, and linked to malaria-endemic regions.
Glucose-6-phosphate isomerase
Glucose-6-phosphate isomerase (GPI, phosphoglucose isomerase), enzyme catalyzing glucose-6-phosphate to fructose-6-phosphate in glycolysis; GPI gene 19q13.1; autosomal recessive GPI deficiency causes chronic nonspherocytic hemolytic anemia, ~100 cases reported.
Glucose-dependent insulinotropic receptor
GPR119, the glucose-dependent insulinotropic receptor, is a lipid-sensing class A GPCR in pancreatic beta cells and gut L cells; activated by OEA and related lipids, it amplifies insulin and GLP-1/GIP secretion and is a type 2 diabetes drug target.
Glucose-galactose malabsorption
Glucose-galactose malabsorption (GGM, congenital glucose-galactose malabsorption, SGLT1 deficiency) is a rare autosomal recessive disease caused by SLC5A1 mutations, causing life-threatening neonatal watery diarrhea treated with a glucose-, galactose-, and lactose-free diet.
Glucose-responsive microneedle insulin patch
A glucose-responsive microneedle insulin patch, or smart insulin patch, is a transdermal device whose micron-scale needles release insulin at a rate that adjusts automatically to glucose concentration.
Glucosinolate
Glucosinolates (GSLs), also called mustard oil glucosides, are sulfur-rich anionic plant secondary metabolites of the Brassicales order, hydrolyzed by myrosinase into isothiocyanates, thiocyanates, and nitriles for defense and human health effects.
Glucosyl hesperidin
Glucosyl hesperidin (GH, monoglucosyl hesperidin, CitraPeak) is an enzymatically glucosylated, water-soluble form of the citrus flavonoid hesperidin; GRAS (GRN 901, 2020) in the US and EU novel food authorized 2025.
Glucosylated steviol glycosides
Glucosylated steviol glycosides, also called enzyme-modified steviol glycosides, are stevia-derived sweeteners with 1–20 added glucose units made via CGTase from starch; about 120–150 times sweeter than sucrose, GRAS-notified in the US and EFSA-assessed.
Glucosyltransferase
Glucosyltransferase: glucose-transferring glycosyltransferase (EC 2.4.1.5) building glucans from donors like UDP-glucose and sucrose; a B. subtilis/S. salivarius version is FDA GRAS (GRN 1210, 2025).
Glucuronic acid
Glucuronic acid: C6-oxidized glucose sugar acid; as UDP-glucuronic acid it drives hepatic glucuronidation of bilirubin, hormones, and drugs via UGT enzymes (40-75% of xenobiotic elimination), and gut microbial beta-glucuronidases reverse the conjugation.
Glucuronidation
Glucuronidation: phase II metabolism in which UGT enzymes attach glucuronic acid from UDP-glucuronic acid to drugs and endobiotics like bilirubin, forming water-soluble glucuronides excreted via transporters; UGT1A1, UGT2B7, inhibition, induction, polymorphisms.
Glucuronoxylan synthase
Glucuronoxylan synthase is the Golgi-localized glycosyltransferase complex, built from IRX9, IRX10, and IRX14 proteins, that synthesizes the xylan backbone of glucuronoxylan in plant cell walls.
GLUE (benchmark)
GLUE, the General Language Understanding Evaluation benchmark, is a suite of nine NLP tasks and a leaderboard introduced in 2018 to test whether one model handles many language tasks.
GLUE and SuperGLUE
GLUE and SuperGLUE, the General Language Understanding Evaluation benchmarks, are English natural language understanding benchmark suites, GLUE released in 2018 and SuperGLUE its harder 2019 successor.
Glueball
A glueball, also called gluonium, is a hypothetical particle made entirely of gluons, which carry color charge and can bind to each other; candidates include f0(1710) and X(2370).
Glued laminated timber
Glued laminated timber, commonly called glulam, is an engineered structural wood product made by bonding lumber with adhesives, patented in 1906 and used in beams, arches, and bridges.
GlueX
GlueX (Gluonic Excitations Experiment) is a particle physics experiment in Hall D at Jefferson Lab, Newport News, Virginia, that searches for exotic hybrid mesons with a polarized photon beam.
Glufosfamide
Glufosfamide (beta-D-glucosyl-isophosphoramide mustard, D19575) is an investigational glucose-conjugated alkylating prodrug of ifosfamide mustard, cleaved by intracellular glucosidases; tested through phase III mainly in pancreatic cancer without approval.
Glufosinate
Glufosinate is a non-selective, foliar herbicide, sold as an ammonium salt, derived from phosphinothricin, a natural amino acid produced by Streptomyces soil bacteria that kills plants by inhibiting glutamine synthetase and is used on glufosinate-tolerant crops.
GLUG
GLUG (Pfam PF07581, InterPro IPR011493) is a conserved bacterial protein domain named for its G-L-any-G motif, found in IgA1 (M26) peptidases and haemagglutinin-like surface proteins, distinct from the Drosophila Glug glucose transporter gene.
Gluino
The gluino is the hypothetical supersymmetric partner of the gluon, a color-charged, electrically neutral Majorana fermion and a central Large Hadron Collider search target, excluded below roughly 2.25 TeV.
Glumetinib
Glumetinib (谷美替尼, gumarontinib, SCC244, brand Haiyitan) is a selective type Ib MET tyrosine kinase inhibitor approved in China (2023) and Japan (2024) for MET exon 14 skipping-mutant advanced NSCLC, dosed 300 mg once daily, with GLORY phase II ORR 66%.
Gluon
The gluon is the spin-1 gauge boson of the strong interaction, which binds quarks into protons and neutrons; it was discovered at the PETRA collider in 1979.
Gluon field
The gluon field, also called the gluon four potential, is the gauge field of quantum chromodynamics, the SU(3) theory of the strong interaction, whose quanta are the gluons.
GlusterFS
GlusterFS is a free and open-source scale-out network filesystem that pools the storage of many servers, created by Gluster and acquired by Red Hat in 2011.
GLUT4
GLUT4 (SLC2A4), the insulin-responsive glucose transporter of skeletal and cardiac muscle and adipose tissue, discovered 1988, cloned 1989; insulin and exercise drive its translocation from GLUT4 storage vesicles to the cell surface via Akt-AS160/TBC1D4-Rab signaling; its impairment underlies insulin resistance in type 2 diabetes.
Glutamate (neurotransmitter)
Glutamate (L-glutamate, MSG's parent amino acid) is the mammalian brain's principal excitatory neurotransmitter, acting via AMPA, NMDA, kainate, and metabotropic receptors, cleared by EAAT transporters, recycled through the glutamate-glutamine cycle, and central to plasticity, learning, and excitotoxic disease.
Glutamate decarboxylase
Glutamate decarboxylase (GAD, EC 4.1.1.15) is a PLP-dependent enzyme converting L-glutamate to GABA and CO2. Mammals have GAD65 and GAD67 isoforms; GAD65 is a type 1 diabetes and stiff-person syndrome autoantigen; bacterial GAD mediates acid resistance.