All articles starting with P
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PDCD10
PDCD10 (CCM3, TFAR15) is a human gene at 3q26.1 encoding a 212-amino-acid adaptor protein of the CCM signaling and STRIPAK complexes; its mutations cause cerebral cavernous malformation type 3, about 10 percent of familial cases, with an aggressive early-onset course.
PDCD1LG2
PDCD1LG2 (PD-L2, B7-DC, CD273) is a human chromosome 9 gene encoding a B7-family ligand of PD-1, binding it 2-6-fold more strongly than PD-L1 and also binding RGMb; studied as a cancer immunotherapy target.
PDCD4
PDCD4 (programmed cell death 4, H731), a tumor suppressor gene on human chromosome 10 (10q25.2), encodes a 469-aa protein that binds eIF4A via two MA3 domains, blocks translation initiation, and whose loss predicts poor cancer survival.
PDCD5
PDCD5 (TFAR19), a human chromosome 19q13.11 gene encoding a pro-apoptotic protein that translocates to the nucleus, regulates the TIP60/HDAC3-p53 pathway, and shows reduced expression in several cancers.
PDCD6
PDCD6, also called ALG-2 or ALG2, is a human gene at 5p15.33 encoding a 22-kDa penta-EF-hand calcium-binding protein involved in apoptosis, COPII vesicle transport, ESCRT membrane repair, and cancer.
PDCD6IP
PDCD6IP (ALIX, AIP1), human gene at 3p22.3 encoding an ESCRT scaffold protein with Bro1, V, and proline-rich domains; acts in cytokinesis abscission, endosomal vesicle formation, HIV budding, exosome biogenesis; mutations cause microcephaly-29.
PDDL
PDDL, or Planning Domain Definition Language, is a standardized formal language for describing planning domains and problem instances to automated planners, created in 1998 for the AIPS-98 planning competition.
PDE-constrained optimization
PDE-constrained optimization is a class of optimization problems minimizing a cost functional subject to partial differential equations as constraints, underlying optimal control, inverse problems, and design, with the adjoint equation supplying gradients.
PDE4B
PDE4B (phosphodiesterase 4B, DPDE4/PDEIVB) is a cAMP-specific type IV phosphodiesterase gene on chromosome 1p31.3 with five isoforms, linked to schizophrenia, bipolar disorder, and TNFα inflammatory signaling, and a drug target for selective PDE4B inhibitors.
PDE4D
PDE4D (phosphodiesterase 4D, DPDE3, STRK1) is a human chromosome 5 gene encoding a cAMP-degrading phosphodiesterase; one of four PDE4 genes, linked to acrodysostosis, asthma susceptibility, and ischemic stroke.
PDE4D7
PDE4D7 is a splice variant of the PDE4D gene that degrades cAMP and acts as a tumor suppressor in prostate cancer, where its loss predicts poor survival.
PDE5 inhibitor
PDE5 inhibitors (sildenafil/Viagra, tadalafil/Cialis, vardenafil, avanafil) block phosphodiesterase type 5, prolonging NO-cGMP signalling. Developed for angina, approved for erectile dysfunction from 1998 and pulmonary arterial hypertension; nitrates are contraindicated.
PDF, or Portable Document Format, is a fixed-layout file format developed by Adobe and launched in 1993, made an ISO standard in 2008 and used for contracts, reports, forms, and papers.
PDF Solutions
PDF Solutions, Inc. is a Santa Clara, California provider of analytics software, test hardware, and services for semiconductor manufacturing, founded in 1991 and traded on Nasdaq as PDFS.
PDF/A
PDF/A is a family of ISO standards (ISO 19005) defining PDF variants for the long-term preservation of electronic documents, first published in 2005, with PDF/A-4 released in 2020.
PDF417
PDF417 is a two-dimensional stacked barcode symbology invented in 1991 by Ynjiun P. Wang at Symbol Technologies, standardized as ISO/IEC 15438, and used on US and Canadian driver licenses and airline boarding passes.
PDGA World Championships
PDGA World Championships: annual disc golf world titles run by the Professional Disc Golf Association since 1982 (Los Angeles). Four events since 2018: Professional, Masters, Amateur, Junior; 2025 pro champions Gannon Buhr and Ohn Scoggins in Finland.
PDGF/VEGF receptor family
The PDGF/VEGF receptor family is a group of receptor tyrosine kinases with split kinase domains, comprising five class III receptors (PDGFRα, PDGFRβ, KIT, CSF1R, FLT3) and three VEGF receptors.
PDGFB
PDGFB (c-sis, SIS) is a human chromosome 22 gene encoding platelet-derived growth factor subunit B, the B-chain once identified with the v-Sis oncogene; it drives pericyte recruitment, BBB integrity, and FDA-approved wound healing.
PDGFRA
PDGFRA (platelet derived growth factor receptor alpha), gene at 4q12 encoding PDGFRα tyrosine kinase receptor; mutated in about 10% of GISTs, D842V exon 18 mutation is imatinib-resistant and treated with avapritinib.
PDHA1
PDHA1 is an X-linked human gene at Xp22.12 encoding the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex; its variants cause most primary pyruvate dehydrogenase deficiency.
PDIA3
PDIA3 (ERp57, GRP58, 1,25D3-MARRS), gene ID 2923 at 15q15.3, encodes a 56.8 kDa ER protein disulfide isomerase that folds glycoproteins with calnexin/calreticulin and forms the MHC I peptide-loading complex.
PDK4
PDK4 (pyruvate dehydrogenase kinase 4, MIM:602527) is a gene on 7q21.3 encoding a mitochondrial kinase that inhibits the pyruvate dehydrogenase complex by phosphorylating E1α, regulating glucose metabolism; overexpressed in type 2 diabetes muscle.
PDNONG trial
PDNONG (NCT07321470) is a randomized trial at National Taiwan University Hospital testing complete nasogastric tube omission (CONGT, thick needle suction) versus postoperative-only omission (PONGT) after pancreaticoduodenectomy in 240 patients, primary endpoint Clavien-Dindo grade II or higher complications within 90 days.
PDOGG
Pdogg (피독) is the professional name of Kang Hyo-won, a South Korean record producer at Big Hit Music who has been BTS's main producer since their 2013 debut.
PDP-1
The PDP-1, also known as the DEC PDP-1, was the first computer sold by Digital Equipment Corporation, an 18-bit interactive machine first shipped in November 1960.
PDP-10
The PDP-10, marketed as the DECsystem-10, was a 36-bit mainframe computer family made by Digital Equipment Corporation from 1967 to 1983, influential in timesharing and the early ARPANET.
PDP-11
The PDP-11 was a family of 16-bit minicomputers sold by Digital Equipment Corporation of Maynard, Massachusetts, from 1970 into the 1990s, with about 600,000 units sold.
PDP-8
The PDP-8, also known as the DEC PDP-8, is a 12-bit minicomputer introduced by Digital Equipment Corporation in 1965, considered the first commercially successful minicomputer.
PDPK1
PDPK1 (PDK1), 3-phosphoinositide-dependent protein kinase-1, EC 2.7.11.1, is an AGC-family serine/threonine kinase that activates AKT, S6K, SGK, RSK, and PKC via activation-loop phosphorylation; a cancer signaling hub with no approved selective inhibitor.