All articles starting with S
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SLC2A2
SLC2A2 (GLUT2) is a human gene on chromosome 3q26.2 encoding a low-affinity, bidirectional glucose transporter of liver, kidney, intestine, and pancreatic beta cells; biallelic mutations cause Fanconi–Bickel syndrome.
SLC2A3
SLC2A3 (GLUT3), human gene at 12p13.31 encoding the high-affinity facilitative glucose transporter of neurons, axons and dendrites; transports glucose, galactose, mannose, xylose, not fructose; knockout is embryonic lethal.
SLC2A6
SLC2A6 (GLUT6), human gene at 9q34.2 encoding a class 3 GLUT lysosomal sugar transporter; low glucose affinity, NF-κB-regulated, linked to cancer prognosis and macrophage immunity.
SLC30A8
SLC30A8, also known as ZnT8, is a human gene on chromosome 8 that encodes a zinc transporter in pancreatic beta cells; its variants affect type 2 diabetes risk.
SLC31A1
SLC31A1 (CTR1, COPT1) is the human gene at 9q32 encoding a 190-amino-acid homotrimeric, energy-independent high-affinity copper(I) importer that also transports cisplatin and carboplatin, linking copper homeostasis to platinum chemotherapy sensitivity.
SLC35A1-CDG
SLC35A1-CDG (CDG-IIf, CMP-sialic acid transporter deficiency) is an ultrarare autosomal recessive glycosylation disorder from SLC35A1 mutations, with about six reported cases, causing seizures, ataxia, and macrothrombocytopenia.
SLC35A2-CDG
SLC35A2-CDG, formerly CDG-IIm or DEE22, is a rare X-linked dominant glycosylation disorder caused by SLC35A2 variants affecting the Golgi UDP-galactose transporter, causing infantile epileptic encephalopathy, hypotonia, and severe developmental delay, treatable in trials with galactose supplementation.
SLC35C1-CDG (CDG type IIc, LAD II)
SLC35C1-CDG, also called LAD II or CDG-IIc, is a rare autosomal recessive glycosylation disorder caused by SLC35C1 mutations at 11p11.2 that disable the Golgi GDP-fucose transporter, abolishing sialyl Lewis X, impairing leukocyte rolling, and treatable in part with oral L-fucose.
SLC39A8-CDG
SLC39A8-CDG (CDG-IIn, CDG2N, SLC39A8 deficiency) is a rare autosomal recessive congenital disorder of glycosylation caused by ZIP8 manganese-transporter variants, causing manganese depletion, type II transferrin profile, severe neurologic impairment, treatable with manganese and galactose.
SLC3A2
SLC3A2, also called 4F2hc, CD98hc, or FRP-1, is a human type II membrane glycoprotein on chromosome 11q13 that chaperones six SLC7 light-chain amino acid exchangers and links integrins to signaling; it is overexpressed in many cancers.
SLC47A1
SLC47A1 (MATE1) is a human gene at 17p11.2 encoding a proton-coupled organic cation antiporter that exports metformin, cationic drugs, and toxins from kidney and liver apical membranes; variants affect drug response.
SLC4A1
SLC4A1 (AE1, band 3, Diego blood group) encodes the red cell chloride/bicarbonate anion exchanger, a 911-aa, 14-transmembrane-segment protein; mutations cause spherocytosis, ovalocytosis, stomatocytosis, and distal renal tubular acidosis.
SLC5A1
SLC5A1 (SGLT1, sodium/glucose cotransporter 1) is a human gene at 22q12.3 encoding the 2Na+:1-glucose symporter that absorbs dietary glucose and galactose in the intestine; mutations cause glucose-galactose malabsorption.
SLC6A1
SLC6A1 (GAT1, GABATR) is a human gene at 3p25.3 encoding the sodium- and chloride-coupled GABA transporter 1; pathogenic variants cause SLC6A1-related neurodevelopmental disorder with developmental delay, epilepsy, and autism through GAT1 haploinsufficiency.
SLC6A2
SLC6A2 (NET, norepinephrine transporter) is a human gene at 16q12.2 encoding a 617-amino-acid, 12-transmembrane Na+/Cl−-coupled transporter that recycles norepinephrine into presynaptic terminals; loss-of-function variants cause orthostatic intolerance.
SLC6A4
SLC6A4 (5-HTT, SERT) is the human chromosome 17 gene encoding the serotonin transporter, the SSRI and amphetamine target; its 5-HTTLPR promoter polymorphism is widely studied but not clinically actionable.
SLC7A11
SLC7A11 (xCT, CCBR1), human gene at 4q28.3, encodes the light chain of system xc−, a sodium-independent antiporter importing cystine against glutamate 1:1 to supply glutathione; overexpressed in cancers, governs ferroptosis, targeted by erastin and sulfasalazine.
SLC7A5
SLC7A5 (LAT1), large neutral amino acid transporter 1, is the light chain of the LAT1/CD98 (SLC3A2) heterodimer, a sodium- and pH-independent amino acid antiporter at the blood-brain barrier and placenta, overexpressed in cancers and targeted by the inhibitor nanvuranlat (JPH203).
SLC9A1
SLC9A1, also known as NHE1, is a human protein-coding gene on chromosome 1p36.11 encoding sodium/hydrogen exchanger 1, a ubiquitous antiporter that regulates intracellular pH; mutations cause Lichtenstein-Knorr syndrome.
SLC9A3
SLC9A3 is a human gene coding for NHE3, a sodium/hydrogen exchanger in the intestine and kidney that drives sodium absorption, and whose mutations cause congenital sodium diarrhea.
SLCO1B1
SLCO1B1 (OATP1B1, OATP-C) is a liver-specific human transporter gene on chromosome 12p12 that clears bilirubin and statins; the rs4149056 variant reduces function and raises statin myopathy risk.
SLCO1B3
SLCO1B3, on chromosome 12, encodes OATP1B3 (OATP8), a liver-specific hepatic uptake transporter for statins, bile acids, bilirubin, and hormones; combined OATP1B1/1B3 deficiency causes Rotor syndrome.
SLCO2A1
SLCO2A1 (PGT, OATP2A1) is a human gene at 3q22.1 encoding a prostaglandin transporter; loss-of-function mutations cause primary hypertrophic osteoarthropathy (PHOAR2, PHOAD) and CEAS via elevated PGE2.
SLCO2B1
SLCO2B1 (OATP2B1, OATP-B, SLC21A9), gene ID 11309 on 11q13.4, encodes a broadly expressed organic anion uptake transporter, the main intestinal OATP, with pH-dependent transport, fruit juice drug interactions, and clinically annotated variants.
Sleaford Mods
Sleaford Mods, also styled Sleaford Mods (post-punk duo), are an English Nottingham-formed electronic punk pair of Jason Williamson's ranted vocals and Andrew Fearn's minimal beats, known for Austerity Dogs, UK Grim (UK No. 3) and 2026's The Demise of Planet X.
Sleater-Kinney
Sleater-Kinney: American riot grrrl-rooted rock band formed 1994 in Olympia, Washington, by Corin Tucker and Carrie Brownstein; eleven albums 1995–2024, including Dig Me Out, One Beat, and Little Rope.
Sleazy Dizzy
Sleazy Dizzy (小偷阿星, Siu tau ah sing) is a 1990 Hong Kong comedy-crime film directed by Chor Yuen, starring Stephen Chow as a thief helping an amnesiac undercover cop find missing HK$50 million; box office HK$7,968,106.
Sled
Sled is rider slang for a motorcycle, usually a heavy cruiser, and also names the desert sleds raced in Southern California from the 1950s, mostly Triumph 650 twins.
Sled dog
Sled dog: a working dog trained to pull sleds over snow and ice; Siberian lineage 9,500 years old; breeds like Siberian Husky and Alaskan Malamute; used for mail, the 1925 serum run, and races like the 1,000-mile Iditarod.
Sledge Hammer!
Sledge Hammer! is a satirical American police sitcom created by Alan Spencer, starring David Rasche as a gun-obsessed Dirty Harry parody, airing 41 episodes on ABC from 1986 to 1988.