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Small incision lenticule extraction

Small incision lenticule extraction (SMILE) is a refractive surgery in which a femtosecond laser cuts a disc of tissue inside the cornea, removed through a small incision to correct myopia.

Small Industries Development Bank of India (लघु उद्योग विकास बैंक भारत)

Small Industries Development Bank of India (लघु उद्योग विकास बैंक भारत), or SIDBI, is India's development finance institution for micro, small, and medium enterprises, established in 1990.

Small interfering RNA

Small interfering RNA (siRNA), the ~19–30 bp duplex of RNA interference, guides Argonaute/RISC to cleave matching mRNA; discovered via Fire and Mello's 2006 Nobel work, with patisiran the first FDA-approved siRNA drug (2018).

Small intestinal bacterial overgrowth

Small intestinal bacterial overgrowth (SIBO), also called bacterial overgrowth of the small bowel, is excessive bacteria in the small intestine causing diarrhea, bloating, and malabsorption; diagnosis by jejunal aspirate culture or breath tests is contested.

Small intestinal biopsy

A small intestinal biopsy is a diagnostic procedure that takes mucosal tissue samples from the duodenum during upper endoscopy and examines them under the microscope, principally to diagnose celiac disease.

Small intestine

Small intestine: the 3–5 m duodenum–jejunum–ileum tube between stomach and colon; performs 90–95% of nutrient absorption, absorbs 7–8 of 9 daily liters of water, and shows five molecular regions.

Small Is Beautiful

Small Is Beautiful: Economics as if People Mattered is a 1973 essay collection by economist E. F. Schumacher arguing for human-scale work, technology, and ownership over unlimited growth.

Small Island Developing States

Small Island Developing States (SIDS) are small island and low-lying coastal countries recognized by the United Nations since 1992, totaling 39 states with about 65 million people.

Small kidney

Small kidney (ICD-11 MF54.2; renal hypoplasia or kidney atrophy): a kidney under 11 cm long and 120 g, from congenital underdevelopment or acquired shrinkage from infection, blockage, or vascular disease.

Small kinetochore-associated protein

Small kinetochore-associated protein (SKAP, kinastrin, KNSTRN, UniProt Q9Y448) is a 316-aa microtubule plus-end tracking protein that partners with Astrin to stabilize bioriented kinetochore-microtubule attachments, reduce friction, and support mouse spermatogenesis.

Small Laude

Small Laude (Marissa Eduardo Laude, born 1968) is a Filipino socialite and lifestyle vlogger whose Small's World YouTube channel, started in 2019 at Karen Davila's urging, grew past 2 million subscribers; she also runs Timson Printing with husband Philip Laude and the skincare brand Small Steps Skin.

Small Leucine-Rich Proteoglycans

Small leucine-rich proteoglycans (SLRPs), also called small leucine-rich repeat proteoglycans, are the largest proteoglycan family: 18 members in five classes, 36–42 kDa LRR cores, regulating collagen fibrillogenesis and ECM assembly.

Small lymphocytic lymphoma

Small lymphocytic lymphoma is an indolent cancer of B lymphocytes, mainly in enlarged lymph nodes, the same disease as chronic lymphocytic leukemia with under 5 × 10⁹/L cells in blood.

Small Magellanic Cloud

The Small Magellanic Cloud (Nubecula Minor) is a dwarf irregular galaxy orbiting the Milky Way about 200,000 light-years away, visible to the naked eye from the Southern Hemisphere.

Small modular reactor

A small modular reactor, or SMR, is a nuclear reactor of up to 300 MWe whose modules are fabricated in a factory and shipped to site for assembly.

Small nuclear ribonucleoprotein F

Small nuclear ribonucleoprotein F (snRNP-F, Sm-F, SNRPF) is a core spliceosomal Sm protein forming the heptameric Sm ring of U1, U2, U4, U5, U7 and minor snRNPs, essential for pre-mRNA splicing and snRNP assembly.

Small nuclear ribonucleoprotein G

SNRPG (Sm-G, small nuclear ribonucleoprotein G) is a human 2p13.3 gene encoding an 8.5 kDa Sm core protein of the U1, U2, U4, and U5 snRNPs and the minor U12 spliceosome, assembled by the SMN complex, with reported roles in cancer.

Small nuclear RNA

Small nuclear RNA (snRNA; U1-U6, U11, U12, U4atac, U6atac): 100-300-nucleotide nuclear RNAs forming the catalytic core of major and minor spliceosomes that remove introns from pre-mRNA.

Small nucleolar RNA

Small nucleolar RNA (snoRNA; SNORD/SNORA genes): short non-coding RNAs in the nucleolus that, as box C/D and H/ACA snoRNPs, guide rRNA 2'-O-methylation, pseudouridylation, and pre-rRNA cleavage.

Small nucleolar RNA host gene 1

SNHG1 (small nucleolar RNA host gene 1; UHG, U22HG, LINC00057) is a human lncRNA gene at 11q12.3 hosting eight SNORD snoRNAs, upregulated in many cancers and a proposed prognostic biomarker.

Small nucleolar RNA SNORD115

SNORD115 (HBII-52) is a paternally expressed cluster of about 47 orphan C/D box snoRNA genes at the imprinted 15q11-q13 Prader-Willi locus, with an 18-nt complementarity to HTR2C exon Vb and a modifying interaction with SNORD116.

Small nucleolar RNA SNORD116

SNORD116 (HBII-85) is an orphan box C/D snoRNA cluster in the paternally imprinted SNHG14 host gene at 15q11-q13; its loss causes Prader-Willi syndrome, and mouse deletion produces hyperphagia and growth deficiency.

Small nucleolar RNA U3

U3 snoRNA (SNORD3A) is the first-discovered, most abundant box C/D small nucleolar RNA, ubiquitous in eukaryotes; it guides pre-rRNA cleavage at A0/A1/A2 for 18S rRNA, forms the SSU processome with fibrillarin and Utp proteins, and has mitotic and antiviral roles.

Small open economy

A small open economy is a country that trades and borrows internationally yet is too small to influence world prices, making it a price taker in world markets.

Small pelagic fish body oil

Small pelagic fish body oil (SPPFBO), GRAS Notice 102, is whole-body oil from sardine, anchovy, and similar planktivorous fish, rich in EPA and DHA, permitted in US foods up to 3 g/day combined.

Small plaque parapsoriasis

Small plaque parapsoriasis (chronic superficial dermatitis, digitate dermatosis) is a benign chronic scaly skin disease with patches under 5 cm on the trunk; rarely progresses to mycosis fungoides; treated with narrowband UVB phototherapy.

Small Plum Blossoms in a Mountain Garden

Small Plum Blossoms in a Mountain Garden (山园小梅, Shan yuan xiao mei) is a plum blossom poem by the Northern Song poet Lin Bu (967–1028), famous for its couplet on sparse shadows and hidden fragrance.

Small Pond

Small Pond (小池) is a seven-character quatrain by the Southern Song poet Yang Wanli, composed in 1176 at his Jishui home and now taught in Chinese first-grade textbooks.

Small press science fiction publishing

Small press science fiction publishing covers specialist SF and fantasy presses in two waves: hardcover pioneers from 1946, and collector presses from the 1970s reprinting 1950s paperback originals.

Small Prophets

Small Prophets is a 2026 BBC Two sitcom created, written and directed by Mackenzie Crook, starring Pearce Quigley and Michael Palin, about a man growing prophesying homunculi in his Manchester garden shed; renewed for a BBC One second series.