All articles starting with T

TOPAZ trial (NCT07734792)

TOPAZ (NCT07734792) is a phase 2/3 randomized trial testing early tirzepatide, a dual GLP-1/GIP agonist, in 726 thrombectomy-treated acute ischemic stroke patients with large vessel occlusion across China; primary endpoint mRS 0-1 at 90 days.

TOPBP1

TOPBP1 (DNA topoisomerase II binding protein 1, HGNC:17008, 3q22.1) is a human scaffold protein with nine BRCT domains that activates the ATR checkpoint kinase, initiates DNA replication, and mediates repair and mitotic chromosome tethering with CIP2A.

TOPCAT trial

TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) was an NHLBI-funded trial of spironolactone in HFpEF: 3,445 patients, neutral primary endpoint (HR 0.89), reduced HF hospitalization, and marked Russia/Georgia regional heterogeneity.

Topcoder

Topcoder is a crowdsourcing platform founded in April 2001 by Jack Hughes that pioneered online algorithm contests and runs crowdsourced software development, design, and data science work for clients.

Tope Awotona

Tope Awotona is a Nigerian-born software entrepreneur who founded Calendly in Atlanta in 2013, funding it with his life savings; a 2021 round valued it at over $3 billion.

Tope Lawani

Temitope "Tope" Lawani is a Nigerian investor who co-founded Helios Investment Partners in London in 2004, the largest Africa-focused private investment firm, backing companies like Helios Towers and Fawry.

Topeiros (Paradeisos)

Topeiros (Τοπειρός), also Paradeisos, an ancient Thracian city on the west bank of the Nestos in Thrace, a Via Egnatia station; founded 1st century AD, coinage under Antoninus Pius to Geta, Slav capture 549-550, Justinianic refortification.

Topeka (ferry)

Topeka was the concept name of a planned Norwegian zero-emission RoRo cargo ship powered by liquid hydrogen under Wilhelmsen's EU-funded HySHIP project, designed for a Stavanger–Kristiansund route before the newbuild was canceled.

Topeka, Kansas

Topeka, Kansas, the state capital and fifth-largest city (about 126,000 people), home of Washburn University and the Kansas State Capitol, and the defendant city in the 1954 Brown v. Board of Education school desegregation ruling.

TOPEX/Poseidon

TOPEX/Poseidon was a joint NASA and CNES satellite mission launched in 1992 that used radar altimetry to measure sea-surface height across the global ocean, beginning the precise satellite record of sea-level rise.

Topfreedom

Topfreedom is the movement for women's right to go bare-chested in public where men may, also called topfree equality or Free the Nipple. Key facts: New York legalized it in 1992, Ontario in 1996, GoTopless founded 2007.

Topgolf

Topgolf: golf entertainment chain founded 2000 in Watford, England, with RFID-chipped balls, target-based scoring games, Toptracer tracking, and food and beverage at 100+ venues; merged with Callaway 2021, 60% sold to Leonard Green effective January 1, 2026.

Toph Beifong

Toph Beifong (北方拓芙), the Blind Bandit, is a blind earthbending master from Avatar: The Last Airbender who teaches Aang, bends metal via seismic sense, later leads Republic City police, and appears in Korra, Netflix live action (Miya Cech), and games.

Tophaceous gout

Tophaceous gout, also called chronic tophaceous gouty arthropathy, is advanced gout with tophi, urate crystal deposits in tissues; treated with treat-to-target urate-lowering therapy, lower urate targets, and pegloticase for refractory tophi.

Topher Conway

Topher Conway is an American venture capitalist and Managing Partner at SV Angel, the San Francisco firm founded by his father Ron Conway, which he joined in 2009.

Topher DiMaggio

Topher DiMaggio, born Michael Romeo Christopher Fink, is an American gay adult film performer and underwear model, best known as Superman in a 2016 porn parody.

Topher Grace

Topher Grace (Christopher John Grace, born 1978) is an American actor known for Eric Forman on That '70s Show, Venom in Spider-Man 3, David Duke in BlacKkKlansman, and Home Economics.

Tophet (תֹּפֶת)

Tophet (תֹּפֶת) is a biblical site in the Valley of Hinnom near Jerusalem, and the modern label for Punic sanctuaries at Carthage and elsewhere holding urns of cremated children.

Tophet of Carthage

The Tophet of Carthage (Precinct of Tanit) is a Punic sanctuary in Carthage where burned remains of young children and animals were buried in urns until 146 BC.

Tophet of Motya

The Tophet of Motya is a Punic burial precinct on San Pantaleo island, Sicily, holding cremation urns of infants used from the 8th to 4th century BC.

Tophet of Sulcis

The Tophet of Sulcis is a Phoenician and Punic open-air sanctuary at Sant'Antioco, Sardinia, where urns holding cremated stillborn and young children were buried from the 8th century BC.

Tophet of Tharros

The Tophet of Tharros is a Punic open-air sanctuary of infant cremations and stelae at Tharros, Sardinia, used from the 7th to the 2nd century BC.

Oct 22, 2026

Topi Shukla

Topi Shukla (टोपी शुक्ला) is a Hindi novel by Rahi Masoom Raza, published in 1969, following the friendship of a Hindu boy, Topi, and a Muslim boy, Iffan.

Topia

Topia, originally MOVE Guides, is a privately held software company founded in 2010 and headquartered in Denver, Colorado. Its platform helps enterprises manage global mobility and cross-border compliance.

Topiary

Topiary: the art of clipping evergreen shrubs and trees, chiefly box and yew, into geometric or fanciful shapes; originated in imperial Rome, revived in Renaissance Italy, still practiced in gardens such as Levens Hall.

Topic

Topic, born Tobias Topić, is a German DJ and producer from Solingen known for his melancholic dance music and the 2019 multi-platinum hit "Breaking Me" with A7S.

Topic Maps

Topic Maps is an ISO standard (ISO/IEC 13250), first published in 2000, that encodes knowledge as topics, associations, and occurrences, overlaid on collections of documents like an index.

Sep 29, 2026

Topic modeling

Topic modeling is a family of statistical and machine learning methods for large document collections, best known through latent Dirichlet allocation, introduced by Blei, Ng, and Jordan in 2002.