95 articles
WNT1
WNT1 (Wnt family member 1, formerly int1) is a chromosome 12q13.12 gene encoding a secreted Wnt ligand acting via Frizzled and LRP5/6; heterozygous variants cause dominant early-onset osteoporosis, biallelic variants osteogenesis imperfecta type XV.
WNT3A
WNT3A (Wnt family member 3A), human gene at 1q42.13 encoding Wnt-3a, a 352-amino-acid secreted canonical Wnt ligand that binds Frizzled and LRP5/6 to stabilize beta-catenin, acting in stem cell self-renewal, development, and cancer.
WNT4
WNT4 (Wnt family member 4, SERKAL) is a human gene at 1p36.12 encoding a secreted Wnt ligand required for Müllerian duct formation, ovarian androgen suppression, and kidney development; mutations cause SERKAL syndrome and Müllerian aplasia with hyperandrogenism.
WNT5A
WNT5A (Wnt family member 5A, gene ID 7474) encodes a secreted WNT glycoprotein ligand for Frizzled-5 and ROR2, the prototypic non-canonical WNT ligand; mutations cause autosomal dominant Robinow syndrome and dysregulation links to cancer metastasis.
Zygote arrest protein 1
Zygote arrest protein 1 (ZAR1, Zar1) is an oocyte-specific maternal-effect RNA-binding protein essential for the oocyte-to-embryo transition; its loss causes one-cell embryo arrest and female infertility, and human ZAR1 variants cause oocyte maturation failure.