edgepedia

Nuclear medicine and molecular imaging

63 articles

4D PET

4D PET is a respiratory-gated PET technique that sorts scan data into bins of the breathing cycle, reducing motion blur for lung and liver tumors and radiotherapy planning.

Albumin, iodinated i 125 serum

Albumin, iodinated I 125 serum (125I-HSA, RISA-125, Jeanatope) is human serum albumin labeled with iodine-125, a diagnostic radiopharmaceutical (ATC V09GB02) for plasma and blood volume measurement, now largely replaced by 99mTc-albumin.

Albumin, iodinated i 131 serum

Albumin, iodinated i 131 serum (RISA, iodinated 131I human serum albumin, INN 2804) is a diagnostic radiopharmaceutical of human serum albumin labeled with iodine-131, used for blood and plasma volume, cardiac output, and blood-pool imaging; first commercial radiopharmaceutical (Abbott, 1950).

Amyloid PET

Amyloid PET is a brain positron emission tomography scan measuring amyloid-β plaque density in adults with cognitive impairment, used to select and monitor amyloid antibody therapy.

Besilesomab

Besilesomab (Scintimun, clone BW 250/183) is a murine IgG1 antibody against granulocyte antigen NCA-95/CD66b, radiolabelled with technetium-99m for scintigraphic imaging of peripheral bone osteomyelitis in adults; EU-approved 2010, not for diabetic foot, HAMA-limiting.

Binodenoson

Binodenoson (MRE-0470, Corvue) is a selective adenosine A2A receptor agonist developed by King Pharmaceuticals for pharmacologic stress SPECT myocardial perfusion imaging; effective versus adenosine with fewer side effects, but never FDA approved and development discontinued.

Bone scan

A bone scan, or bone scintigraphy, is a nuclear medicine imaging test in which a radioactive tracer reveals abnormal bone turnover across the whole skeleton.

Copper Cu-64 SAR-bisPSMA

Copper Cu 64 SAR-bisPSMA (64Cu-SAR-bisPSMA) is a bivalent PSMA-targeting PET radiotracer with a sarcophagine chelator and 12.7-hour Cu-64 half-life, developed by Clarity Pharmaceuticals for prostate cancer imaging and paired with Cu-67 for therapy.

DMSA scan

A DMSA scan is a nuclear medicine imaging test using a technetium-99m tracer to picture functioning kidney cortex, most often in children after urinary tract infection.

Dynamic PET

Dynamic PET is a nuclear medicine imaging method that records PET data continuously after tracer injection, fitting tracer kinetics to quantify physiological rate constants rather than a single static image.

Emission computed tomography

Emission computed tomography (ECT) is a nuclear medicine method that reconstructs 3D images of injected radioactive tracers for diagnosis and treatment planning, with SPECT and PET as its two branches.

First-Pass Ventriculography

First-pass ventriculography (FPRNV, first-pass radionuclide angiography): nuclear medicine technique imaging a radionuclide bolus during one transit through the heart; preferred for right ventricular ejection fraction and intracardiac shunts, distinct from equilibrium MUGA.

Florbetaben

Florbetaben (18F), brand name Neuraceq, code 18F-BAY94-9172, is an 18F-labeled stilbene PET radiotracer for brain beta-amyloid plaque imaging in cognitive impairment, approved by EMA and FDA in 2014, dosed at 300 MBq.

Florbetapir

Florbetapir (Amyvid, florbetapir F 18) is an FDA-approved fluorine-18 PET radiotracer binding beta-amyloid neuritic plaques, used to evaluate Alzheimer's disease and select patients for amyloid beta-directed therapy.

Flortaucipir

Flortaucipir (¹⁸F, Tauvid, AV-1451, T807) is an FDA-approved (2020) PET radiotracer binding aggregated tau neurofibrillary tangles to evaluate Alzheimer's disease; 370 MBq dose, 0.57 nM PHF-tau affinity, not indicated for CTE.

Fluciclovine

Fluciclovine F18 (Axumin, 18F-FACBC) is a synthetic leucine-analogue PET radiotracer approved in 2016 (FDA) and 2017 (EMA) for imaging suspected prostate cancer recurrence after elevated PSA, now largely superseded by PSMA tracers.

Fluorine-18 fluorodeoxyglucose PET

Fluorine-18 fluorodeoxyglucose PET, or FDG PET, is a nuclear medicine scan that maps glucose metabolism using a radiolabeled glucose analog, widely used to detect, stage, and monitor cancer.

Flutafuranol

Flutafuranol, also called 18F-AZD4694 or 18F-NAV4694, is a fluorine-18 benzofuran PET radiotracer for brain beta-amyloid plaques, developed by AstraZeneca, with Kd 2.3 nM, low white matter binding, and near-identical imaging to 11C-PiB; used in research, not approved.

Flutemetamol

Flutemetamol, sold as Vizamyl, is a radioactive diagnostic agent injected intravenously for brain PET imaging that estimates amyloid beta plaque density in adults with cognitive impairment.

Gallium citrate

Gallium citrate (Ga-67, Ga-68 citrate) is a radiopharmaceutical iron analogue for imaging infection, inflammation, and tumors; Ga-67 SPECT imaging at 48-72 hours, Ga-68 PET with 68-minute half-life.

Gallium-68 DOTATATE PET-CT

Gallium-68 DOTATATE PET-CT, also known as 68Ga-DOTATATE PET/CT, is a nuclear medicine scan using a gallium-labeled somatostatin analog to image neuroendocrine tumors, FDA approved in 2016.

Gated Blood-Pool Imaging

Gated blood-pool imaging, also called MUGA, ERNA, or gated radionuclide ventriculography, is an ECG-gated nuclear medicine scan using Tc-99m-labeled red blood cells to measure left ventricular ejection fraction reproducibly, mainly for chemotherapy cardiotoxicity monitoring.

Gated single-photon emission computed tomography

Gated single-photon emission computed tomography (gated SPECT, GSPECT) is a nuclear medicine method, developed in the late 1980s, that synchronizes heart perfusion imaging with the cardiac cycle to measure left ventricular function.

Gozetotide

Gozetotide (PSMA-11) is a peptide radioactive diagnostic agent labeled with gallium-68 for PET imaging of PSMA-positive prostate cancer lesions; sold as Illuccix, Locametz, and GOZELLIX, and used to select patients for Pluvicto radioligand therapy.

Hepatobiliary scintigraphy

Hepatobiliary scintigraphy, also called cholescintigraphy or HIDA, is a nuclear medicine scan that tracks an injected radioactive tracer through the liver and bile system, chiefly to diagnose acute cholecystitis.

Imciromab pentetate

Imciromab pentetate (Myoscint, R11D10) is a murine Fab antibody fragment against cardiac myosin, DTPA-conjugated and indium-111 labeled for imaging myocardial infarction; FDA approved July 3, 1996, withdrawn 1999.

ImmunoPET

ImmunoPET is a molecular imaging method in nuclear medicine that pairs radiolabeled monoclonal antibodies with PET to measure where a target accumulates in a patient.

ImmunoPET imaging

ImmunoPET imaging is a molecular imaging method in nuclear medicine that uses radiolabeled monoclonal antibodies and PET to map targets such as HER2 and PD-L1 across all lesions at once, mainly in oncology.

In vivo PET imaging

In vivo PET imaging is a molecular imaging method that visualizes an injected radiotracer in a living organism, used mainly in oncology since the late 1980s.

Iodine i 124 girentuximab

Iodine-124 girentuximab (Redectane, 124I-cG250) is a PET radiotracer of CAIX for detecting clear cell renal cell carcinoma; validated in REDECT (sensitivity 86.2%, specificity 85.9%), later superseded by 89Zr-girentuximab.