63 articles
Iodohippurate
Iodohippurate (ortho-iodohippuric acid, OIH) is a hippuric acid radiopharmaceutical labeled with I-123 or I-131, cleared by renal tubular secretion (OAT1, ~500-600 mL/min) for renography and effective renal blood flow measurement.
Lymphoscintigraphy
Lymphoscintigraphy is a nuclear medicine imaging method that tracks radiolabeled particles through lymphatic vessels and nodes, used to diagnose lymphedema and guide sentinel lymph node biopsy in breast cancer and melanoma.
M-fluorobenzylguanidine
M-fluorobenzylguanidine (MFBG, florbenguane F 18, IRP 101) is an investigational fluorine-18 PET tracer, a norepinephrine analog taken up via hNET, studied for neuroblastoma, pheochromocytoma/paraganglioma, and cardiac sympathetic imaging, outperforming 123I-MIBG.
MIBG & SSTR NB study
MIBG & SSTR NB (NCT07064746) is a prospective observational Nanjing First Hospital trial comparing 123I-MIBG SPECT/CT with 68Ga-DOTA-TATE SSTR PET for diagnosing and staging neuroblastoma in 150 Chinese children aged 0-18.
MIBG scintigraphy
MIBG scintigraphy is a nuclear medicine scan using radioiodinated MIBG, a norepinephrine analog, to image the heart's sympathetic innervation and adrenergic tumors like pheochromocytoma and neuroblastoma, first reported in 1981.
Molecular breast imaging
Molecular breast imaging (MBI) is a nuclear medicine technique that uses a gamma camera and injected tracer to find breast tumors mammography may miss, especially in dense tissue.
Molecular Imaging (procedure)
Molecular imaging is a medical imaging procedure in which molecularly targeted probes visualize biochemical and cellular processes in living subjects, spanning PET, MRI, ultrasound, fluorescence, and microscopy.
Nuclear stress test
A nuclear stress test is a cardiac imaging procedure that combines exercise or drug-induced stress with a radioactive tracer to diagnose and risk-stratify coronary artery disease.
Patlak plot
The Patlak plot, also called the Gjedde-Patlak plot, is a graphical method in pharmacokinetic imaging that estimates the irreversible tracer uptake rate constant Ki from dynamic PET data.
Pentetreotide
Pentetreotide (Octreoscan, indium In 111 pentetreotide) is a DTPA conjugate of octreotide radiolabeled with indium-111 for somatostatin receptor scintigraphy of neuroendocrine tumors; FDA approved 1994, now largely replaced by gallium-68 SSTR PET.
PET reconstruction
PET reconstruction is the computational step that converts coincidence events recorded by a PET scanner into a 3D image of radiotracer concentration, typically using statistical methods like MLEM and OSEM.
PET/CT imaging
PET/CT imaging, also called FDG PET/CT, is a hybrid nuclear medicine examination that fuses PET metabolic activity with CT anatomy, improving cancer staging accuracy by roughly 10–15%.
Piflufolastat
Piflufolastat (18F-DCFPyL; Pylarify in the US, Pylclari in the EU) is a fluorine-18-labeled PSMA-targeted PET radiotracer for staging and detecting recurrent prostate cancer, FDA approved May 2021.
Pittsburgh compound B
Pittsburgh compound B (PiB, [11C]6-OH-BTA-1) is a carbon-11 PET radiotracer developed by Mathis and Klunk at the University of Pittsburgh from thioflavin T; first used in humans in 2002, it images beta-amyloid plaques and serves as the reference standard for amyloid PET tracers.
PSMA PET
PSMA PET is a nuclear medicine imaging method that detects and stages prostate cancer using radiotracers binding prostate-specific membrane antigen, standard of care since 2020.
Radioimmunodetection
Radioimmunodetection (RAID), also called radioimmunoscintigraphy, is a nuclear medicine technique using radiolabeled monoclonal antibodies to image tumors; it evolved into immunoPET after FDG-PET displaced it for staging.
Radioisotope Diagnostic Techniques
Radioisotope diagnostic techniques, the basis of nuclear medicine, use radiotracers imaged by SPECT and PET to show organ function; Tc-99m, F-18 FDG, and I-123 are the workhorse isotopes.
Radionuclide Generators
A radionuclide generator, colloquially a "radioisotope cow," is a device holding a long-lived parent isotope whose short-lived daughter is repeatedly "milked" off for nuclear medicine imaging.
Renal scintigraphy
Renal scintigraphy is a nuclear medicine imaging method that injects a radioactive tracer, records its passage through the kidneys with a gamma camera, and measures perfusion, function, and drainage.
Renography
Renography, or dynamic renal scintigraphy, is a nuclear medicine imaging method that tracks an injected radiotracer through the kidneys to measure function, perfusion, and urinary drainage.
Somatostatin receptor scintigraphy
Somatostatin receptor scintigraphy (SRS) is a nuclear medicine scan using radiolabeled octreotide to image neuroendocrine tumors; introduced in 1992, it was superseded by SSTR PET.
Targeted PET imaging
Targeted PET imaging is a nuclear medicine method using radiolabeled tracers that bind molecular targets like PSMA or somatostatin receptors, visualized by positron emission tomography.
Technetium (99mtc) apcitide
Technetium (99mTc) apcitide, also 99mTc-P280, brand AcuTect, is a technetium-99m-labeled cyclic peptide radiopharmaceutical binding platelet glycoprotein IIb/IIIa receptors, FDA-approved September 14, 1998 (NDA 020887) for imaging acute venous thrombosis and now discontinued.
Technetium bicisate
Technetium (99mTc) bicisate (ECD, Neurolite) is a lipophilic 99mTc radiopharmaceutical for brain SPECT perfusion imaging, FDA-approved in 1994 as an adjunct to CT/MRI for stroke localization, trapped in brain by esterase hydrolysis.
Technetium tc-99m trofolastat chloride
Technetium (99mTc) trofolastat chloride, also MIP-1404 or RoTecPSMA, is a urea-based PSMA-targeting technetium-99m SPECT/CT radiotracer for prostate cancer imaging, approved in the UK (2025) and Switzerland (2025).
Technetium teboroxime
Technetium teboroxime (Cardiotec, SQ30217), a BATO-class 99mTc myocardial perfusion SPECT tracer with 85-90% extraction and rapid washout; FDA-approved 1990, discontinued, abandoned clinically due to fast washout.
Tetrofosmin
Tetrofosmin (Myoview) is a lipophilic cationic diphosphine chelating technetium-99m, a SPECT radiopharmaceutical for myocardial perfusion and left ventricular function imaging, FDA approved 1996, distinguished from sestamibi by faster liver clearance.
Theranostics
Theranostics, a term coined in 1998 fusing therapy and diagnostics, is the nuclear medicine practice of imaging a tumor target and treating it with a matched radiopharmaceutical.
Time-of-flight positron emission tomography
Time-of-flight positron emission tomography (TOF-PET) is a nuclear medicine imaging technique that uses photon arrival-time differences to localize emissions, improving image quality, especially in large patients.
Total-body PET
Total-body PET is positron emission tomography with a long axial field of view that images the whole adult body in one bed position, cutting radiation dose sharply.