429 articles
Common Terminology Criteria for Adverse Events
The Common Terminology Criteria for Adverse Events (CTCAE) is a vocabulary and five-point severity scale from the US National Cancer Institute for grading adverse events in cancer trials.
CONAN trial
The CONAN trial was a phase 4 randomized trial at the Clínica Universidad de Navarra in Pamplona, Spain, testing antibiotic lock solutions in implanted venous port catheters.
CONDITION trial
CONDITION trial (NCT05253820): single-center randomized trial comparing distal vs conventional transradial access for coronary procedures; distal access cut 3-month radial artery occlusion from 3.3% to 0.8% but lowered puncture success.
COOBA trial
COOBA (NCT04112251), Effects of COcoa Supplement in OBese Adolescent Subjects: Mexican randomized double-blind placebo-controlled trial of 500 mg cocoa flavonol capsules (100 mg/day epicatechin) for 12 weeks in obese adolescents aged 10–16, measuring body fat, TG/HDL-C, and HOMA-IR; completed 2020, sponsor National Polytechnic Institute, Mexico.
COOP-DANCE trial
COOP-DANCE (NCT06644690) was a Turkish assessor-blinded pilot RCT testing CO-OP occupational therapy plus creative dance versus CO-OP alone in 26 older adults with mild cognitive impairment; no executive-function benefit.
COPD-LTOT trial
COPD-LTOT (NCT03020212) is a completed randomized trial by Fundación Neumológica Colombiana testing long-term oxygen therapy in 220 COPD patients with PaO2 50–55 mm Hg living at 2,640 m in Bogotá, evaluating adjusted oxygen criteria via pulmonary hypertension and erythrocytosis outcomes.
COSINE study
COSINE (NCT05945043), a Guy's and St Thomas' NHS Trust observational study continuing SINE, measuring neural respiratory drive by surface EMG and breathlessness in 124 pleural effusion patients before and after thoracocentesis, 2023-2027.
CP fascia trial
CP fascia trial (NCT06837025), a Finnish pilot RCT comparing Stecco fascial manipulation with traditional stretching in 20 children aged 7-14 with spastic cerebral palsy, GMFCS II-III, one weekly session for 8 weeks; feasibility-focused, results expected 2027.
CRT_TriageER study
CRT_TriageER (NCT07054151) is a 2024 cross-sectional study by Sofuoglu and Başer, Izmir Democracy University, of capillary refill time in 313 emergency department patients, finding mean CRT 2.00 s, longer in red triage codes.
CSM study
CSM study: the AOSpine CSM North America (NCT00285337) and CSM International (NCT00565734) prospective cohort studies of cervical spondylotic myelopathy surgery, 757 patients, 26 sites, 2005-2011, led by Michael Fehlings.
cSVF-Lung trial
cSVF-Lung (NCT03909750, GARM 2 Lung) was a suspended Phase 1 Healeon Medical trial testing autologous adipose-derived stromal vascular fraction by IV infusion in COPD and restrictive lung disease, 50 planned participants.
DAI trial
DAI trial (NCT05471180), a withdrawn randomized double-blind Brazilian trial testing 660 nm diode laser photobiomodulation plus protective spray film versus sham for incontinence-associated dermatitis in 78 hospitalized adults.
DANAMI-3 trial
DANAMI-3 (Third Danish Study of Optimal Acute Treatment of Patients With STEMI), a Danish program of three randomized trials (iPOST, DEFER, PRIMULTI) at 4 centers, 2011-2014, testing postconditioning, deferred stenting, and complete revascularization in STEMI.
DANISH trial
DANISH (Danish Study to Assess the Efficacy of ICDs in Non-ischemic Systolic Heart Failure on Mortality), 2016 NEJM randomized trial of 1,116 patients: prophylactic ICD did not reduce all-cause mortality but halved sudden cardiac death.
Dapa-CKD trial
DAPA-CKD (Dapagliflozin And Prevention of Adverse Outcomes in Chronic Kidney Disease), NCT03036150: AstraZeneca-funded phase 3 trial of dapagliflozin 10 mg vs placebo in 4304 patients with proteinuric CKD stages 2–4, with or without type 2 diabetes; 39% relative risk reduction in the primary renal-cardiovascular composite endpoint.
DCIS trial
DCIS trial (NCT03002766): Milan phase 2 prospective study of 224 women testing a margin-width plus risk-factor score to omit radiotherapy after breast-conserving surgery for ductal carcinoma in situ; 1.138% yearly recurrence with 57.6% avoiding radiation.
DEAL-COVID19 trial
DEAL-COVID19 (NCT05808231) was an Indonesian multicenter randomized trial testing quinine sulfate as add-on therapy for hospitalized adults with mild-to-moderate COVID-19; its published cohort of 25 patients showed no significant efficacy differences versus standard care.
DEFINE-FLOW trial
DEFINE-FLOW (NCT02328820), a prospective nonrandomized multicenter trial of 455 patients in Europe and Japan, tested combined FFR and CFR measurement for coronary stenoses; intact CFR did not make low-FFR lesions safe to defer revascularization.
DICEE trial
DICEE trial (Deflated and Inflated Cuff Endotracheal Extubations, NCT06990308): a single-center blinded randomized trial at Naval Medical Center Camp Lejeune comparing deflated versus inflated cuff extubation in 88 healthy adults after non-airway surgery, using contrast chest radiography to detect airway contamination.
DIMAN study
DIMAN (NCT02680327) is a prospective observational feasibility pilot at the Montreal Heart Institute testing recruitment and retention of elderly cardiac surgery patients for a multicenter audit of advance care planning practices and end-of-life communication satisfaction, using CANHELP questionnaires and 5-meter gait speed frailty assessment.
DIMS trial
DIMS trial (NCT03165812), A Diabetes Improvement in Medical Therapy Versus SADJB Study: Malaysian trial comparing SADJB-SG bariatric surgery with intensive medical therapy for type 2 diabetes in Asian patients with BMI 23.5-30 kg/m2; 84 planned participants, no results posted.
DIOPSYS trial
DIOPSYS trial (NCT03642782): a single-arm diagnostic study at Groupe Hospitalier Paris Saint-Joseph, Paris, sponsored by Fondation Hôpital Saint-Joseph, testing the Diopsys NOVA pattern electroretinogram for early glaucoma diagnosis; 12 patients planned, started July 2018, now suspended.
Disease-Free Survival
Disease-free survival (DFS), also called relapse-free survival (RFS), is an oncology clinical trial endpoint measuring time after primary treatment without signs or symptoms of cancer; the FDA accepts it as a surrogate for overall survival in adjuvant settings such as resected colon cancer, melanoma, renal cell cancer, GIST, breast cancer, and stage III NSCLC.
DISMUD study
DISMUD (NCT03295175), Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis, a withdrawn observational study by Hospital Universitario San Ignacio, Bogota, comparing dartos smooth muscle in congenital megaprepuce, hypospadias, and controls; zero enrolled.
DissEcT trial
DissEcT (NCT06992453), Disentangling Microbiome Engraftment by Multi-omics of the Gut Ecosystem During Fecal Transplant, is a Rome-based trial using multi-omics to study FMT engraftment in rCDI, ulcerative colitis, and metabolic syndrome.
DISTROKE trial
DISTROKE (NCT03626558), Diaphragmatic Function Description in Stroke Patients, was a withdrawn French preliminary ultrasound study of post-stroke diaphragm function; no participants were enrolled and no results were posted.
DN trial
DN trial (NCT02838394, "Dry Needling and Functional Improvement"): Brigham Young University randomized trial testing whether gluteal trigger point dry needling evokes segmental neuromodulation and reduces disability; terminated, 20-participant target, blunted-needle sham.
DOMINO trial
DOMINO (Doxycycline versus Macrolides for Mycoplasma pneumoniae INfectiOn in Children) is a planned South Korean multicentre randomised trial, NCT07306234, testing first-line doxycycline versus azithromycin in 208 children aged 3–17 with suspected macrolide-resistant M. pneumoniae pneumonia.
DreaminLMBC study
DreaminLMBC (NCT05550090, ZCHBC022) is an observational study using DCE-MRI combined with IVIM-DWI to predict early chemotherapy sensitivity of breast cancer liver metastases in about 40 patients.
DRTST trial
DRTST (Duodenal Resection Tri-Staple Technology), NCT03277144, is an Italian multicenter randomized trial led by Maurizio Degiuli, University of Turin, comparing three-line Tri-Staple stapler closure of the duodenal stump against conventional techniques during open gastrectomy for gastric cancer, targeting 700 patients.