88 articles
Gefurulimab
Gefurulimab (ALXN1720, Klygefa) is a humanized bispecific VHH nanobody from Alexion/AstraZeneca that binds C5 and albumin, blocking terminal complement activation; once-weekly subcutaneous therapy for AChR-Ab+ generalized myasthenia gravis with positive CHMP opinion in September 2026.
Hansoh CDH17 antibody-drug conjugate (licensed to Roche)
HS-20110 is Hansoh Pharma's CDH17-targeting antibody-drug conjugate with a topoisomerase inhibitor payload, in Phase I trials for colorectal cancer; Roche licensed worldwide rights (excluding Greater China) for US$80 million upfront plus up to US$1.45 billion in milestones.
HBM9033 (MSLN ADC)
HBM9033 (PF-08052666, SGN-MesoC2) is a mesothelin-targeted antibody-drug conjugate with a camptothecin-based topoisomerase 1 inhibitor payload, DAR 8, developed by Harbour BioMed/Nona Biosciences, licensed to Pfizer for $53 million upfront plus up to $1.05 billion milestones, and discontinued in 2026 after a terminated Phase 1 trial.
HMPL-A830
HMPL-A830 is HUTCHMED's first-in-class KRAS inhibitor payload conjugated to an anti-EGFR antibody (ATTC) for solid tumors; in Phase I/IIa trial NCT07718581 and licensed to GSK ex-Greater China for up to US$1.295 billion.
Idursulfase beta
Idursulfase beta (Hunterase, GC1111) is a CHO-cell recombinant iduronate-2-sulfatase for weekly IV enzyme replacement therapy in Hunter syndrome (MPS II), approved in Korea in 2012, with higher FGly content and specific activity than idursulfase (Elaprase).
Iltamiocel
Iltamiocel, formerly known as autologous muscle-derived cells (AMDC), is an investigational cell therapy developed by Cook MyoSite in Pittsburgh, studied for stress urinary incontinence, fecal incontinence, and dysphagia.
Indium in 111 satumomab pendetide
Indium In 111 satumomab pendetide, sold as OncoScint CR/OV by Cytogen, is a discontinued diagnostic radiopharmaceutical, the first FDA-approved tumor-imaging agent for immuno-SPECT, approved in 1992.
Ivonescimab (AK112)
Ivonescimab (依沃西单抗, AK112/SMT112) is Akeso's first-in-class tetravalent Fc-silent bispecific antibody blocking PD-1 and VEGF, licensed to Summit Therapeutics for up to $5 billion; approved in China for NSCLC, with HARMONi-2 beating pembrolizumab on PFS and OS.
Izalontamab brengitecan
Izalontamab brengitecan (伦康依隆妥单抗, iza-bren, BL-B01D1, BMS-986507) is a first-in-class EGFR×HER3 bispecific antibody-drug conjugate with a topoisomerase I inhibitor payload, approved in China in 2026 for nasopharyngeal and esophageal cancers.
Levilimab
Levilimab (BCD-089, Ilsira) is a fully human IgG1 monoclonal antibody against the interleukin-6 receptor from Biocad, Russia; approved there in 2020 for severe COVID-19 cytokine release syndrome and studied in rheumatoid arthritis; ATC L04AC25; no US/EU approval.
LM-305 (GPRC5D ADC)
LM-305 (AZD0305) is LaNova Medicines' anti-GPRC5D antibody-drug conjugate with an MMAE payload for multiple myeloma; NMPA IND approved November 2022, phase 1/2 trial NCT05647512, exclusively licensed to AstraZeneca in May 2023 for up to $600 million.
Loncastuximab tesirine
Loncastuximab tesirine, sold as Zynlonta and developed as ADCT-402, is a CD19-targeted antibody–drug conjugate linking a monoclonal antibody to the PBD dimer SG3199, FDA-approved in 2021 for relapsed or refractory large B-cell lymphoma.
Mevonlerbart
Mevonlerbart (REGN1909) is a fully human monoclonal antibody from Regeneron that binds Fel d 1, the dominant cat allergen, and is in Phase 3 development for cat allergy.
Mocertatug rezetecan
HS-20089 (GSK5733584, mocertatug rezetecan) is a Hansoh-discovered, GSK-licensed B7-H4-targeted antibody-drug conjugate with a topoisomerase I inhibitor payload (DAR 6) in phase 3 trials for platinum-resistant ovarian cancer.
Narsoplimab
Narsoplimab (OMS721, YARTEMLEA, narsoplimab-wuug) is Omeros' fully human IgG4 monoclonal antibody inhibiting MASP-2, the lectin complement pathway effector enzyme; FDA-approved December 2025 for transplant-associated thrombotic microangiopathy but refused by EMA in 2026.
Nipocalimab
Nipocalimab (Imaavy, M281, JNJ-80202135) is a fully human aglycosylated IgG1 monoclonal antibody blocking FcRn to lower IgG; FDA-approved in 2025 for generalized myasthenia gravis and in 2026 for warm autoimmune hemolytic anemia.
Octocog alfa
Octocog alfa is recombinant full-length human coagulation factor VIII for haemophilia A, sold as Advate (Takeda, 2003) and Kovaltry (Bayer); intravenous replacement therapy, prophylaxis, and surgery, not for von Willebrand disease.
Oleclumab
Oleclumab (MEDI9447) is AstraZeneca/MedImmune's human anti-CD73 monoclonal antibody that blocks adenosine-mediated immunosuppression; tested with durvalumab in NSCLC (COAST, PACIFIC-9), pancreatic, colorectal, and breast cancer trials.
Oportuzumab monatox
Oportuzumab monatox (Vicinium, Vicineum, VB4-845) is an investigational anti-EpCAM scFv fused to Pseudomonas exotoxin A, given intravesically for BCG-unresponsive bladder cancer; FDA CRL and EMA withdrawal in 2021.
Pegunigalsidase alfa
Pegunigalsidase alfa (Elfabrio, pegunigalsidase alfa-iwxj) is a PEGylated recombinant alpha-galactosidase A enzyme replacement therapy made in tobacco cells, approved in 2023 for adults with Fabry disease, dosed 1 mg/kg IV every 2 weeks, noninferior to agalsidase beta in the BALANCE trial.
Pozelimab
Pozelimab (Veopoz, pozelimab-bbfg, REGN3918) is Regeneron's fully human anti-C5 IgG4P monoclonal antibody, FDA-approved August 18, 2023 as the first treatment for CHAPLE disease (CD55-deficient protein-losing enteropathy), and in phase 3 trials with cemdisiran for PNH and myasthenia gravis.
Recaticimab injection
Recaticimab (艾心安, AiXinAn; SHR-1209) is a long-acting humanized IgG1 anti-PCSK9 monoclonal antibody with an Fc YTE mutation, approved in China in 2025 for hypercholesterolemia and mixed dyslipidemia, dosed every 4 to 12 weeks.
Recombinant human interferon alfa-1b
Recombinant human interferon alfa-1b (重组人干扰素α1b), China's first gene-engineering Class I new drug, cloned by Hou Yunde in 1982; brands SinoGene and Yundesu; used for viral hepatitis, pneumonia, and pediatric viral infections.
Reslizumab
Reslizumab (Cinqair, Cinqaero) is a humanized IgG4-kappa anti-IL-5 monoclonal antibody for add-on treatment of severe eosinophilic asthma in adults, given as 3 mg/kg intravenous infusion every 4 weeks, with a boxed anaphylaxis warning.
Riferminogene pecaplasmid
Riferminogene pecaplasmid (NV1FGF, XRP0038) is a Sanofi-aventis pCOR plasmid gene therapy expressing FGF-1 for critical limb ischemia; its phase III TAMARIS trial showed no benefit over placebo.
Riliprubart
Riliprubart (SAR445088, BIVV020, TNT020) is Sanofi's investigational humanized IgG4 monoclonal antibody inhibiting activated C1s in the classical complement pathway, studied in cold agglutinin disease and CIDP; its MOBILIZE phase 3 CIDP trial was stopped for futility in June 2026.
Risvutatug rezetecan
Risvutatug rezetecan (HS-20093, GSK5764227, Ris-Rez) is a B7-H3-targeted antibody-drug conjugate from Hansoh Pharma, licensed to GSK; its phase 3 ARTEMIS-008 trial showed 18.5 vs 10.3 months overall survival versus topotecan in relapsed SCLC.
Rolditamig deuderuxtecan
Rolditamig deuderuxtecan (TQB2102) is a HER2 bispecific antibody-drug conjugate from Chia Tai Tianqing (Sino Biopharmaceutical), targeting HER2 ECD II and ECD IV with a cleavable linker and topoisomerase I inhibitor payload; licensed exclusively to Cipla for India, South Africa, and five other emerging markets in August 2026.
Ruplizumab
Ruplizumab (hu5c8, BG9588, ANTOVA), a humanized IgG1 anti-CD40L monoclonal antibody for lupus nephritis and ITP; effective but halted for thromboembolic events caused by FcγRIIa-mediated platelet activation.
Sacituzumab drozuntecan
DB-1305/BNT325 (sacituzumab drozuntecan) is DualityBio's third-generation TROP2-targeting ADC using topoisomerase-I inhibitor P1021 on the DITAC platform; partnered with BioNTech ex-Greater China, in Phase I/IIa trials (NCT05438329) with FDA Fast Track designation.