88 articles
Sacituzumab govitecan
Sacituzumab govitecan (Trodelvy, sacituzumab govitecan-hziy) is a Trop-2-directed antibody-drug conjugate linking a humanized anti-Trop-2 antibody to SN-38, a topoisomerase I inhibitor; FDA-approved since 2020 for metastatic triple-negative and HR+/HER2- breast cancer.
Sedomigene (NL003, Huasuoling) HGF plasmid
Sedomigene injection (Huasuoling, NL003, Donaperminogene Seltoplasmid) is a naked HGF plasmid gene therapy by Beijing Northland Biotech, approved by NMPA on 28 May 2026 for ischemic limb ulcers in severe lower limb ischemia.
Sigvotatug vedotin
Sigvotatug vedotin (PF-08046047, SGN-B6A) is Pfizer/Seagen's investigational integrin beta-6-directed antibody-drug conjugate with MMAE payload for NSCLC; its phase 3 SigVie-002 trial missed overall survival versus docetaxel, while frontline combination trials with pembrolizumab continue.
Surzebiclimab
Surzebiclimab (BGB-A425), BeiGene's humanized IgG1 anti-TIM-3 monoclonal antibody, blocks TIM-3 ligands PtdSer and galectin-9; tested with tislelizumab and alcestobart in Phase 1/2 trial NCT03744468 for advanced solid tumors, NSCLC and HNSCC.
Tafolecimab
Tafolecimab (IBI 306, SINTBILO) is Innovent Biologics' fully human IgG2 anti-PCSK9 monoclonal antibody for hypercholesterolemia; NMPA approved it in August 2023 as China's first domestic PCSK9 antibody, with CREDIT trials showing 57-65% LDL-C reductions.
Tagitanlimab (KL-A167)
Tagitanlimab (KL-A167, A167, HBM-9167; brand Cotelet, 塔戈利单抗) is Kelun-Biotech's humanized IgG1κ anti-PD-L1 antibody, NMPA-approved in China (Dec 2024, Jan 2025) for recurrent/metastatic nasopharyngeal carcinoma, monotherapy and first-line with cisplatin-gemcitabine.
Tarcocimab tedromer
Tarcocimab tedromer (KSI-301, Zenkuda) is Kodiak Sciences' investigational intravitreal anti-VEGF antibody biopolymer conjugate, a 950 kDa humanized IgG1-polymer conjugate with 20-day ocular half-life for wet AMD, diabetic retinopathy, DME, and retinal vein occlusion.
Technetium tc 99m nofetumomab merpentan
Technetium (99mTc) nofetumomab merpentan, trade name Verluma, is a 99mTc-labeled Fab fragment of murine antibody NR-LU-10, a diagnostic radiopharmaceutical for staging small cell lung cancer, FDA-licensed in 1996 and later discontinued.
Telisotuzumab vedotin
Telisotuzumab vedotin (Teliso-V, Emrelis, ABBV-399) is a c-Met-directed antibody-drug conjugate of telisotuzumab plus MMAE, FDA accelerated approval May 14, 2025 for previously treated high c-Met overexpressing nonsquamous NSCLC.
Tildrakizumab
Tildrakizumab (Ilumya, Ilumetri) is a humanized IgG1 monoclonal antibody blocking the IL-23 p19 subunit, approved from 2018 for moderate-to-severe plaque psoriasis, dosed 100 mg subcutaneously every 12 weeks with an optional 200 mg dose.
Tisotumab vedotin
Tisotumab vedotin (Tivdak, tisotumab vedotin-tftv) is a tissue factor-directed antibody-drug conjugate with an MMAE payload, FDA-approved (accelerated 2021, full 2024) for recurrent or metastatic cervical cancer after chemotherapy; boxed warning for ocular toxicity.
Transglutaminase-mediated antibody conjugation
Transglutaminase-mediated antibody conjugation is an enzymatic bioconjugation method in which microbial transglutaminase from Streptomyces mobaraensis attaches drugs, fluorophores, or other payloads to antibodies, chiefly to build homogeneous antibody-drug conjugates.
Trastuzumab botidotin for injection
Trastuzumab botidotin (博度曲妥珠单抗, A166, brand Shutaile) is a Kelun-Biotech HER2-targeting antibody-drug conjugate with a Duo-5 (MMAF-derivative) payload, DAR 2, approved by China's NMPA in October 2025 for previously treated HER2-positive metastatic breast cancer.
Trastuzumab deruxtecan
Trastuzumab deruxtecan (Enhertu, T-DXd, DS-8201a) is a HER2-directed antibody-drug conjugate linking trastuzumab to the topoisomerase I inhibitor DXd, approved for HER2-positive, HER2-low, and HER2-mutant cancers.
Trastuzumab duocarmazine
Trastuzumab duocarmazine (SYD985, T-Duo, Jivadco) is a HER2-targeted antibody-drug conjugate linking trastuzumab to the duocarmycin prodrug seco-DUBA; it met PFS endpoint in the TULIP phase III trial but its EMA application was withdrawn.
Trastuzumab emtansine
Trastuzumab emtansine (T-DM1, Kadcyla), an antibody-drug conjugate of trastuzumab and the tubulin inhibitor DM1; first ADC approved for a solid tumor (2013) for HER2-positive breast cancer.
Trastuzumab envedotin
Trastuzumab envedotin (DP303c) is a CSPC-developed HER2-targeted antibody-drug conjugate: trastuzumab-sequence IgG1 with site-specific MMAE conjugation (DAR 2.0), phase 3 PFS 8.8 vs 5.8 months versus T-DM1 in HER2-positive advanced breast cancer.
Trastuzumab pamirtecan
DB-1303 (trastuzumab pamirtecan, BNT323) is DualityBio's third-generation HER2-targeting antibody-drug conjugate with a topoisomerase I inhibitor payload; its Phase 3 breast cancer trial met its PFS endpoint and China's NMPA accepted its BLA in 2026.
Trastuzumab vedotin
Trastuzumab vedotin (MRG002) is an investigational HER2-targeting antibody-drug conjugate: fucosylated trastuzumab (MAB802) linked to MMAE via a Val-Cit linker, DAR 3.8, in phase I/II trials for HER2-positive and HER2-low breast and gastric cancers.
Trebananib
Trebananib (AMG 386) is Amgen's investigational Ang1/Ang2-neutralizing peptibody blocking the Tie2 angiopoietin pathway; it extended PFS but not overall survival in ovarian cancer phase 3 TRINOVA trials and was never approved.
Turoctocog alfa
Turoctocog alfa (NovoEight, Novo Nordisk) is a third-generation B-domain-truncated recombinant factor VIII for hemophilia A, made in CHO cells without plasma, approved 2013, with no confirmed inhibitors in the guardian trials.
Uliledlimab (TJD5)
Uliledlimab (尤莱利单抗, TJD5, TJ004309) is I-Mab's humanized anti-CD73 monoclonal antibody for solid tumors; non-competitive intra-dimer binding, tested with toripalimab and atezolizumab, now Phase 2/3 in NSCLC via TJ Biopharma and Sanofi.
Umesolerbart
Umesolerbart (REGN5714) is a Regeneron IgG4 monoclonal antibody against the birch pollen allergen Bet v 1, part of the REGN5713-5714-5715 cocktail for allergic rhinitis, INN recommended 2023, in phase III trials.
Utomilumab
Utomilumab (PF-05082566), Pfizer's fully human IgG2 agonist antibody against 4-1BB (CD137), binds CRD3-4, blocks 4-1BBL, is a weak FcγR-dependent agonist, was safer than urelumab but had limited efficacy, and development was discontinued.
Velaglucerase beta for injection
Velaglucerase beta for injection (Gaurunning, 戈芮宁, CAN103) is a CHO-K1-derived recombinant glucocerebrosidase ERT approved by China's NMPA in May 2025 for type I and III Gaucher disease, ages 12+, first domestic ERT.
Vilobelimab
Vilobelimab (Gohibic, IFX-1), an anti-C5a monoclonal antibody by InflaRx, treats critical COVID-19 under FDA emergency use authorization (2023) and EMA approval (2025); studied in hidradenitis suppurativa and pyoderma gangrenosum.
Zalutumumab
Zalutumumab (HuMax-EGFr, clone 2F8), a fully human IgG1 anti-EGFR monoclonal antibody from Genmab for head and neck cancer; development suspended in 2011 after phase 3 trials showed no overall survival benefit.
Zolbetuximab
Zolbetuximab (Vyloy, IMAB362) is Astellas's first-in-class chimeric IgG1 antibody against claudin 18.2, approved October 2024 with chemotherapy as first-line therapy for CLDN18.2-positive, HER2-negative gastric or gastroesophageal junction adenocarcinoma.