273 articles
Xl550
Xl550 is esaxerenone (CS-3150), a nonsteroidal mineralocorticoid receptor antagonist discovered by Exelixis and approved in Japan (2019) for hypertension and studied in diabetic kidney disease.
Zalunfiban
Zalunfiban (RUC-4, Disaggpro) is an investigational subcutaneous glycoprotein IIb/IIIa inhibitor for STEMI given at first medical contact; the phase 3 CELEBRATE trial (2,467 patients) showed improved artery patency and fewer 30-day adverse outcomes without excess severe bleeding.
Zotarolimus
Zotarolimus (ABT-578), a sirolimus analog, is the antiproliferative drug in Medtronic's Endeavor, Resolute Integrity, Resolute Onyx, and Onyx Frontier coronary stents; it inhibits mTOR via FKBP12 binding.