edgepedia

Human health and medicine

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Complication after organ transplantation

A complication after organ transplantation is any adverse medical condition developing in a recipient as a result of the transplant, rejection, infection, metabolic effects of immunosuppressive drugs, or malignancy.

Complications after hematopoietic stem cell transplantation

Complications after hematopoietic stem cell transplantation (HSCT, HCT) range from early infections, acute GVHD, and sinusoidal obstruction syndrome to late chronic GVHD, cardiovascular, endocrine, renal, neurologic, and second-cancer sequelae, with >70% of 10-year survivors developing chronic health conditions.

Complications and long-term outcomes of Langerhans cell histiocytosis

Long-term outcomes of Langerhans cell histiocytosis (LCH) include diabetes insipidus, orthopedic defects, hearing loss, and neurodegeneration, affecting 71% of multisystem versus 24% of single-system patients.

Complications of hypertension

Complications of hypertension (hypertension-mediated organ damage): pressure-driven injury to heart, brain, kidneys, eyes, and vessels, causing stroke, HFpEF, CKD, retinopathy; 10.9 million deaths in 2021; targets now <130/80 in US guidelines.

Complications of juvenile idiopathic arthritis

Complications of juvenile idiopathic arthritis extend beyond the joints: chronic uveitis that can silently cause vision loss, growth disturbance, leg-length discrepancy, and jaw (TMJ) involvement.

Complications of leprosy

Complications of leprosy (Hansen's disease): leprosy reactions (type 1 reversal, type 2 ENL, Lucio's phenomenon), permanent nerve damage, sensory loss, deformity, and disability, their mechanisms, frequencies, and management.

Component separation technique

The component separation technique (CST) is a surgical method in abdominal wall reconstruction that releases and advances abdominal muscle-fascia layers to close large midline hernia defects without bridging prosthetic material.

Composite graft failure

Composite graft failure: partial or complete loss of a composite graft (skin plus cartilage, fat, or bone; ICD-11 EL54). Pooled fingertip survival 72.8%; risks include smoking, crush injury, proximal amputation, grafts over 1.5 cm.

Composite hemangioendothelioma

Composite hemangioendothelioma (polymorphous hemangioendothelioma) is a rare borderline-malignancy vascular tumor mixing benign, intermediate, and malignant components, mainly on distal extremities; local recurrence is frequent, metastasis rare, YAP1::MAML2 fusions in about 27%.

Composite International Diagnostic Interview

The Composite International Diagnostic Interview (CIDI) is a fully standardized lay-administered interview generating computer-scored ICD and DSM diagnoses of mental disorders, developed by the WHO and used in large epidemiological studies.

Composite lymphoma

Composite lymphoma is an uncommon lymphoma in which two or more histologically distinct lymphoma types arise together in a single site, accounting for about 1–4% of lymphomas.

Composition of the human body

The composition of the human body describes how body mass is partitioned and measured across five levels, from chemical elements to whole organs; water makes up about 60% of body weight.

Compound Binafuxi granules

Compound Binafuxi granules (复方比那甫西颗粒) is a Class 1.1 innovative Uyghur-medicine TCM approved by China's NMPA in February 2025 for heat-type common cold; six-herb formula by Xinjiang Yinduolan, national insurance listed 2026.

Comprehensive genomic profiling

Comprehensive genomic profiling (CGP) is an oncology diagnostic using next-generation sequencing to detect many cancer-related alterations in one assay, matching targeted therapies to the tumor's genomic makeup.

Comprehensive geriatric assessment

Comprehensive geriatric assessment (CGA) is a multidimensional, interdisciplinary diagnostic process that assesses frail older people's medical, psychological, and functional capability to build a coordinated care plan.

Comprehensive Health Care

Comprehensive Health Care (MeSH D003191): provision of the full range of personal health services for diagnosis, treatment, follow-up, and rehabilitation; underlies comprehensive primary health care and universal health coverage.

Comprehensive metabolic panel

Comprehensive metabolic panel (CMP), also called chem 14 or chemistry panel: a routine blood test measuring 14 substances, including glucose, electrolytes, calcium, proteins, liver enzymes, bilirubin, BUN, and creatinine, to assess metabolism, liver, and kidney health.

Comprehensive psychiatry

Comprehensive Psychiatry (Compr Psychiatry), Elsevier journal founded 1960, ISSN 0010-440X; open access, peer-reviewed psychiatry and mental health journal, bimonthly, Q1, edited by Naomi Fineberg.

Compression anastomosis

Compression anastomosis is a sutureless surgical technique that joins bowel or other hollow organs by pressing their walls together until they fuse, using ring, nitinol, or magnet-based devices.

Compression Bandages

Compression bandages are wrapped textile devices applying controlled limb pressure to aid venous return and heal venous leg ulcers; types include long-stretch, short-stretch, four-layer, and zinc-paste Unna boot systems.

Compression facies

Compression facies (ICD-11 LA55; French Faciès de compression; Chinese 面受压[扁脸]) is a facial structural developmental anomaly caused by neurovascular compression of the facial nerve, characterized by facial spasm and abnormal facial expression.

Compression stockings

Compression stockings: graduated elastic garments applying highest pressure at the ankle (RAL classes 18–21 to ≥49 mmHg) for venous ulcers, DVT prophylaxis, lymphedema; classes, evidence, fitting, contraindications, and 2024–2026 guideline updates.

Compression therapy

Compression therapy is a medical treatment applying external pressure to the limbs through bandages, stockings, wraps, or pneumatic devices to improve venous return and lymph drainage.

Compressive optic neuropathy

Compressive optic neuropathy is optic nerve dysfunction caused by sustained mechanical pressure, usually from tumors such as pituitary adenoma or meningioma, causing painless progressive vision loss.

Compulsive behavior

Compulsive behavior: repetitive acts driven by the need to reduce anxiety, seen in OCD, addiction, and related disorders; explained by habit-goal imbalance and treated with ERP.

Compulsive buying disorder

Compulsive buying disorder, also called compulsive buying-shopping disorder (CBSD) or oniomania, is a behavioral condition of irresistible buying urges, loss of control, and harmful consequences; not in DSM-5, listed in ICD-11 under 6C7Y, prevalence about 5%.

Compulsive sexual behaviour disorder

Compulsive sexual behaviour disorder (CSBD), ICD-11 code 6C72, is an impulse control disorder marked by persistent failure to control repetitive sexual impulses causing distress or impairment; excluded from DSM-5, prevalence 1–3%.

Computational methods in neuroengineering

Computational methods in neuroengineering are the mathematical models, signal-processing algorithms, and machine-learning techniques used to analyze neural signals, decode intentions, and control devices interfacing electronics with living neural tissue.

Computational neuroscience

Computational neuroscience, also called theoretical or mathematical neuroscience, applies mathematical models, theoretical analysis, and computer simulation to nervous systems, from ion channels to whole-brain networks.

Computed radiography

Computed radiography (CR) is a digital X-ray method that captures images on reusable phosphor plates in cassettes, then reads them with a laser; it is cheaper and more portable than digital radiography.