25,729 articles
DDOST-CDG
DDOST-CDG (CDG-Ir, OMIM 614507) is an ultra-rare autosomal recessive congenital disorder of N-linked glycosylation caused by DDOST mutations, with hypotonia, developmental delay, and hepatic dysfunction.
De Barsy syndrome
De Barsy syndrome (DBS, ARCL3, OMIM 219150/614438) is an ultra-rare autosomal recessive progeroid cutis laxa disorder with corneal clouding, growth retardation, intellectual disability, and athetoid movements, linked to PYCR1 or ALDH18A1 in some cases.
De materia medica (Περὶ ὕλης ἰατρικῆς)
De materia medica (Περὶ ὕλης ἰατρικῆς) is a first-century Greek pharmacological treatise by Pedanius Dioscorides that dominated European and Middle Eastern medicine for sixteen centuries.
De Quervain syndrome
De Quervain syndrome, or de Quervain's tenosynovitis, is stenosing tenosynovitis of the wrist's first extensor compartment (APL and EPB tendons), named after Fritz de Quervain; corticosteroid injection is first-line, surgery when it fails.
Dead on arrival
Dead on arrival (DOA), also cardiopulmonary arrest on arrival (CPAOA), is a person found dead or with ceased heart or lung function at EMS or hospital arrival; diagnosis, prehospital death determination, and classification effects on survival statistics.
Dead space (physiology)
Dead space (physiology): wasted ventilation, the lung volume not participating in CO2 exchange; anatomic plus alveolar dead space, measured by Bohr or Enghoff equations, elevated in ARDS and pulmonary embolism.
Deaf blind hypopigmentation syndrome, Yemenite type
Yemenite deaf-blind hypopigmentation syndrome (Warburg-Thomsen syndrome, ORPHA:3214) is an exceedingly rare autosomal disorder with patchy skin hypo- and hyperpigmentation, microcornea, coloboma, and severe hearing loss, first described in 1990; a mild SOX10 S135T form is distinguished from the severe SOX10-negative sibling case.
Deafblindness
Deafblindness, also called dual sensory loss or dual sensory impairment, is the combination of hearing and vision loss in one person; its most common genetic cause is Usher syndrome.
Deafness with labyrinthine aplasia, microtia, and microdontia
LAMM syndrome, also called congenital deafness with inner ear agenesis, microtia, and microdontia (OMIM 610706), is a rare autosomal recessive FGF3-related disorder combining profound congenital deafness, absent inner ear structures, small ears, and small widely spaced teeth.
Deafness-enamel hypoplasia-nail defects syndrome
Deafness-enamel hypoplasia-nail defects syndrome, or Heimler syndrome (OMIM 234580, 616617), is a rare autosomal recessive peroxisome biogenesis disorder (PEX1, PEX6, PEX26) causing sensorineural hearing loss, permanent-dentition enamel hypoplasia, nail defects, and retinal dystrophy in most reported cases.
Deafness-infertility syndrome
Deafness-infertility syndrome, also called chromosome 15q15.3 deletion syndrome, is a rare autosomal recessive condition combining mild to moderate hearing loss with male infertility from poorly moving sperm, caused by deletions of the STRC and CATSPER2 genes.
Deafness-intellectual disability syndrome, Martin-Probst type
Martin-Probst syndrome (ORPHA:85321, OMIM 300519) is a rare X-linked recessive disorder with congenital sensorineural hearing loss, intellectual disability, short stature, and facial dysmorphism; the proposed RAB40AL p.D59G cause has been reclassified as non-pathogenic.
DEAL-COVID19 trial
DEAL-COVID19 (NCT05808231) was an Indonesian multicenter randomized trial testing quinine sulfate as add-on therapy for hospitalized adults with mild-to-moderate COVID-19; its published cohort of 25 patients showed no significant efficacy differences versus standard care.
Death
Death: permanent cessation of organism function, determined medically by circulatory-respiratory or neurologic (brain death) criteria under the 1981 UDDA; covers Harvard criteria, 2023 BD/DNC guidelines, DCD donation, and global mortality statistics.
Death during consensual sex
Death during consensual sex, usually sudden cardiac death from myocardial infarction or arrhythmia triggered by the modest 3-5 MET exertion of intercourse; rare, about 0.2% of sudden cardiac deaths, mostly older men with coronary disease.
Death from laughter
Death from laughter: fatal collapse during intense laughter, chiefly through cardiac events such as torsade de pointes in long QT syndrome, or via laughter-induced (gelastic) syncope; famous case is Chrysippus, who reportedly died laughing at a donkey eating figs.
Death of Gloria Ramirez
Death of Gloria Ramirez, the 1994 "Toxic Lady" case at Riverside General Hospital, California, where ER staff fell ill from fumes during her treatment; official cause was kidney failure from cervical cancer, with disputed mass-hysteria and DMSO-to-dimethyl-sulfate explanations.
Death of Leah Betts
Leah Betts (Leah Sarah Betts, 1977–1995) was an Essex schoolgirl who died in 1995 of water intoxication after taking an ecstasy tablet at her 18th birthday party.
Death-grip syndrome
Death-grip syndrome is slang for penile desensitization from frequent, high-pressure masturbation, making partnered climax difficult; not a formal diagnosis, it maps onto delayed ejaculation and is managed by masturbatory retraining.
Deborah Birx
Deborah Birx (Deborah Leah Birx, born 1956), American physician and diplomat; U.S. Global AIDS Coordinator 2014–2020 overseeing PEPFAR, led RV 144 Thai HIV vaccine trial, and White House Coronavirus Response Coordinator 2020–2021.
Deborah E. Powell
Deborah E. Powell, also known as Deborah Elizabeth Powell, was an American academic pathologist who served as Dean of the University of Minnesota Medical School from 2002 to 2009.
Debridement
Debridement is the removal of dead tissue, slough, biofilm, and foreign material from a wound so healing can proceed, using surgical, enzymatic, autolytic, or larval methods.
Decalcification (histology)
Decalcification is a laboratory procedure that removes calcium salts from bone and calcified tissue, using acids or EDTA, so specimens can be cut into thin sections for microscopic diagnosis.
Decalcification Technique
Decalcification technique: histological removal of calcium minerals from bone and teeth (MeSH D003648) using acids such as nitric or formic acid or the chelator EDTA, balancing speed against tissue, antigen, and nucleic acid preservation.
Decamethonium
Decamethonium (Syncurine, C10) is a synthetic bisquaternary depolarizing neuromuscular blocking drug synthesized in 1948 by Barlow & Ing and independently by Zaimis; prototype depolarizer, discontinued for irreversibility.
Decentralized clinical trial
A decentralized clinical trial is a clinical study in which activities like visits, consent, and data collection happen remotely or locally rather than at a traditional trial site.
DECIST trial
DECIST (Dapagliflozin Effect in Cognitive Impairment in Stroke Trial), NCT05565976, a phase 2/3 randomized trial at Universidad de Guanajuato, Mexico, testing 12 months of dapagliflozin 10 mg daily on cognition after ischemic stroke; 270 planned participants, no results posted.
Decitabine
Decitabine, first synthesized in 1964, is a hypomethylating chemotherapy drug used for myelodysplastic syndromes and acute myeloid leukemia, given intravenously as Dacogen or orally with cedazuridine as Inqovi.
Decompression
Decompression (decompression staging, decompression sickness prevention): controlled pressure reduction after diving or caisson work, governed by Haldanian and bubble models such as Bühlmann ZHL-16C, validated against DCS outcomes.
Decompression surgery
Decompression surgery is an operation that relieves pressure on spinal nerves or the spinal cord by removing bone, ligament, or disc material, used mainly for lumbar spinal stenosis and herniated discs.