edgepedia

Human health and medicine

25,729 articles

High-flow oxygen therapy

High-flow oxygen therapy (HFNC) delivers heated, humidified blended air and oxygen through wide-bore nasal prongs at 20 to 70 L/min, used for hypoxemic respiratory failure, post-extubation support, and pediatric bronchiolitis.

High-flux dialysis

High-flux dialysis is a form of hemodialysis that uses dialyzer membranes with high water permeability and larger pores, allowing removal of middle-molecular-weight solutes such as beta-2-microglobulin beyond conventional low-flux clearance.

High-frequency audiometry

High-frequency audiometry, also called extended high-frequency (EHF) audiometry, is a diagnostic hearing test measuring the quietest audible tones above 8 kHz, up to 20 kHz.

High-frequency chest wall oscillation

High-frequency chest wall oscillation (HFCWO) is an airway clearance therapy in which an inflatable vest vibrates the chest at 5–25 Hz to loosen mucus, prescribed mainly for cystic fibrosis.

High-frequency ultrasound imaging

High-frequency ultrasound imaging uses acoustic frequencies above the conventional 2–15 MHz diagnostic range to image superficial tissues at near-microscopic resolution, in ophthalmology, dermatology, and intravascular imaging.

High-frequency ventilation

High-frequency ventilation (HFV) is a ventilation technique delivering tiny tidal volumes at several hundred breaths per minute, used for over 30 years in newborns, especially preterm infants.

High-functioning autism

High-functioning autism is an informal, non-diagnostic label for autistic people with average or above IQ and speech, roughly DSM-5 level 1 ASD; clinicians and advocates now prefer support-needs language.

High-grade B-cell lymphoma

High-grade B-cell lymphoma (HGBL) is an aggressive B-cell non-Hodgkin lymphoma, about 2% of cases, defined by MYC and BCL2 rearrangements or blastoid morphology, and often refractory to standard therapy.

High-grade neuroendocrine carcinoma of the cervix uteri

High-grade neuroendocrine carcinoma of the cervix uteri, also called poorly differentiated neuroendocrine cervical carcinoma, is a rare aggressive cervical cancer (about 1-2% of cases) linked to HPV 18, comprising small cell and large cell types, with 5-year survival around 25-40%.

High-grade second degree atrioventricular block

High-grade (advanced, high-degree) second degree AV block: two or more consecutive non-conducted P waves at a normal atrial rate with some conduction preserved; usually infra-Hisian, generally requiring permanent pacing.

High-intensity interval training

High-intensity interval training (HIIT), including the Norwegian 4x4 protocol of four 4-minute bouts at 85-95% max heart rate, alternates short intense exercise bouts with recovery; it raises VO2max and cardiac function and is used in cardiac rehabilitation.

High-intensity training

High-intensity training (HIIT, SIT, RST): repeated short bursts at ≥90% VO2max or >75% maximal power with recovery periods; improves VO2max, anaerobic capacity, and cardiometabolic health comparably to continuous training in less time.

High-output heart failure

High-output heart failure (HOHF): heart failure with cardiac output >8 L/min or CI >4 L/min/m2, low systemic vascular resistance; caused by obesity, cirrhosis, AV shunts, anemia; vasodilators worsen it.

High-Protein Low-Carbohydrate Diet

High-protein low-carbohydrate diet (Atkins, South Beach): eating pattern high in protein, under 45% energy from carbohydrate, used for weight loss and type 2 diabetes; modest short-term benefit, little long-term advantage over balanced diets.

High-resolution anoscopy

High-resolution anoscopy (HRA) is a colposcopic examination of the anal canal that detects precancerous lesions, the preferred method for anal cancer screening in high-risk groups.

High-resolution manometry

High-resolution manometry (HRM) is a diagnostic technique measuring pressure along the gut with up to 36 sensors about 1 cm apart, chiefly for esophageal motility disorders.

High-resolution melt analysis

High-resolution melt analysis (HRM, also HRMA) is a closed-tube real-time PCR method that detects DNA variants, genotypes SNPs, and estimates methylation without sequencing or labeled probes.

High-resolution microendoscopy

High-resolution microendoscopy (HRME) is a fluorescence imaging technique that passes a miniature fiber-bundle probe through a standard endoscope to image epithelial tissue at cellular resolution in real time.

High-resolution peripheral quantitative computed tomography

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a low-dose X-ray method for imaging the distal radius and tibia in vivo to quantify bone microstructure and volumetric density.

High-Risk Pregnancy

A high-risk pregnancy is one in which the mother, fetus, or both face greater chances of complications during gestation or delivery, though it can still end in a healthy birth.

High-speed videoendoscopy

High-speed videoendoscopy (HSV) is a laryngeal imaging method that records vocal fold vibration at thousands of frames per second, used in voice assessment and research.

High-STEACS trial

High-STEACS (NCT01852123) was a Scottish stepped-wedge cluster-randomized trial of high-sensitivity troponin I with sex-specific 99th centile thresholds in 48,282 patients; it reclassified many women but did not reduce 1-year MI or cardiac death.

Hilar mossy cell

Hilar mossy cell: glutamatergic principal neuron of the dentate gyrus hilus, marked by thorny excrescences, axons reaching up to 35,000 granule cells; key in pattern separation, vulnerable in epilepsy.

Hilaria Baldwin

Hilaria Baldwin, born Hillary Hayward-Thomas in Boston, is an American yoga instructor who co-founded Yoga Vida in New York, married Alec Baldwin in 2012, wrote The Living Clearly Method, and was exposed in 2020 for a fabricated Spanish identity.

Hillchol

Hillchol (BBV131) is a single-strain oral cholera vaccine using an inactivated Hikojima V. cholerae strain, developed by Hilleman Laboratories, launched by Bharat Biotech in India in 2024, non-inferior to Shanchol in Phase III.

HILT trial (NCT07287046)

HILT trial (NCT07287046) is a Mahidol University single-blind randomized trial comparing high-intensity laser therapy with focused extracorporeal shock wave therapy for plantar fasciitis, enrolling an estimated 28 adults with VAS pain outcomes at 12 weeks.

HILUTS trial

HILUTS trial (NCT03633994), a phase 2 randomized quadruple-masked trial at The Christ Hospital, Cincinnati, testing intraoperative heparin bladder instillation (40,000 U) versus saline to reduce lower urinary tract symptoms after benign hysterectomy; no results posted.

Himalaya Wellness Company

Himalaya Wellness Company, formerly Himalaya Drug Company, is an Indian herbal healthcare multinational founded in 1930 by M. Manal in Dehradun, based in Bengaluru, known for Liv.52, Cystone, and Serpina, selling about 500 products in over 100 countries.

Hingu sodhana

Hingu sodhana is the Ayurvedic purification of asafoetida (hingu, Ferula resin), done by frying in ghee per Rasatarangini; studies show reduced ash, moisture, and extractives after processing.

Hingula ghrta

Hingula ghrta: Ayurvedic preparations pairing purified cinnabar (Hingula, HgS, Sadharana Rasa) with medicated ghee (Ghrita), used as vehicle, processing medium, topical base, and part of the classical toxicity regimen.