25,729 articles
Medicina intensiva
Medicina Intensiva (Med Intensiva), Spanish peer-reviewed critical care journal founded 1977, official journal of SEMICYUC and FEPIMCTI; Spanish print ISSN 0210-5691 and English edition ISSN 2173-5727 published by Elsevier since 2011, MEDLINE-indexed, 2025 impact factor 2.5.
Medicinal chemistry
Medicinal chemistry, also called drug design chemistry, is the discipline of designing and synthesizing biologically active molecules; it centers on structure–activity relationships, lead optimization, and now AI-guided and covalent or PROTAC modalities.
Medicine
Medicine: the science and practice of diagnosing, treating, and preventing disease. Covers the diagnostic process, Bayesian test interpretation, evidence-based medicine, drug regulation, health systems, and post-2023 AI and GLP-1 developments.
Medicine Chests
Medicine chests: portable boxed kits of medicines, bottles, scales, and manuals for lay self-medication at home, on ships, and in colonial travel, popular from the late 18th to 19th centuries.
Medicine in Goryeo
Medicine in Goryeo (고려 의학) was the medical system of Korea's Goryeo dynasty from 918 to 1392, combining Chinese medical frameworks with native hyangyak herb medicine.
Medicines and Healthcare products Regulatory Agency
MHRA (Medicines and Healthcare products Regulatory Agency) is the UK executive agency of DHSC, established 1 April 2003 from the MCA and MDA merger, regulating medicines, medical devices, and blood components for transfusion.
Medifoxamine
Medifoxamine (Clédial, Gerdaxyl) was an atypical antidepressant with dopaminergic and serotoninergic action, ATC N06AX13, marketed mainly in France and withdrawn in 1999 after hepatitis cases.
Meditation
Meditation is a mind-body practice of focusing attention on the breath, a word, or an object to calm the mind, with moderate evidence for reducing anxiety, depression, and pain.
Mediterranean diet
Mediterranean diet: plant-forward eating pattern from olive-growing southern Europe, built on olive oil, fish, legumes, and whole grains; UNESCO heritage since 2010, studied in the PREDIMED trial.
Mediterranean diet score
The Mediterranean diet score is a dietary index rating adherence to the traditional Mediterranean diet, devised by Antonia Trichopoulou in 1995 and revised to 0–9 points in 2003.
Medium spiny neuron
Medium spiny neuron (MSN, spiny projection neuron): inhibitory GABAergic projection neuron of the striatum, about 95% of striatal neurons; D1 direct-pathway and D2 indirect-pathway subtypes; lost in Huntington disease.
Medium-chain triglycerides
Medium-chain triglycerides (MCTs), triglycerides of C6–C12 fatty acids such as caprylic and capric acid, are rapidly absorbed fats used in clinical nutrition, ketogenic epilepsy therapy, and supplements.
Medrogestone
Medrogestone (Colprone) is a synthetic oral progestogen, 6,17α-dimethyl-6-dehydroprogesterone, developed by Ayerst, approved in Canada in 1969, never FDA-approved, used in France for progesterone-deficiency disorders, with prolonged use linked to increased meningioma risk (OR 3.49).
Medrysone
Medrysone (HMS) is a weak synthetic topical corticosteroid, 11β-hydroxy-6α-methylpregn-4-ene-3,20-dione, used as 1% ophthalmic suspension for allergic and vernal conjunctivitis and episcleritis, notable for minimal intraocular pressure elevation and discontinued US marketing.
Medtronic
Medtronic (Medtronic plc, NYSE: MDT), Galway, Ireland-based medical device maker founded 1949 by Earl Bakken; invented the 1957 battery-operated wearable pacemaker; treats 70+ conditions across cardiovascular, surgical, and neuroscience portfolios; separated its MiniMed diabetes business in 2026.
Medulla oblongata
The medulla oblongata is the lowermost part of the brainstem, continuous with the spinal cord, which controls breathing, heart rate, and blood pressure and houses nuclei for cranial nerves IX through XII.
Medullary sponge kidney
Medullary sponge kidney (Cacchi-Ricci disease) is a congenital dilatation of medullary collecting ducts causing kidney stones, hematuria, and UTIs; present in 12-20% of calcium stone formers, usually benign.
Medullary tegmental cap dysplasia
Medullary tegmental cap dysplasia (MTCD, ORPHA:727881) is a rare brainstem malformation, first described by Barkovich in 2005, with an abnormal cap protruding from the posterior medullary surface, variable neurodevelopment, and links to Joubert syndrome and FOP.
Medullary thymic epithelial cell
Medullary thymic epithelial cell (mTEC): thymic medulla epithelial cell enforcing central tolerance via promiscuous gene expression of tissue-restricted antigens regulated by Aire and Fezf2; subsets mTEC I-IV include Aire+ mTEChi and tuft-like mTEC IV; AIRE mutations cause APS-1.
Medulloblastoma
Medulloblastoma is a grade 4 malignant embryonal brain tumor of the posterior fossa cerebellum, occurring mostly in children, classified into WNT, SHH, group 3, and group 4 molecular subgroups, treated with surgery, craniospinal radiation, and chemotherapy.
Medusoid
Medusoid is an artificial jellyfish built in 2012 from silicone and rat heart muscle cells by Harvard and Caltech researchers, which swims under an electric field.
Meesmann corneal dystrophy
Meesmann corneal dystrophy (MECD, juvenile epithelial corneal dystrophy, Meesmann-Wilke syndrome) is a rare autosomal dominant corneal epithelial disorder from KRT3 or KRT12 mutations, causing tiny intraepithelial microcysts with little vision loss.
Mefatinib maleate tablets (美凡厄替尼)
Mefatinib maleate tablets (美凡厄替尼, trade name 迈瑞东, mifanertinib maleate, MET-306) is an NMPA-approved Class 1 irreversible EGFR/HER2 inhibitor for first-line EGFR L858R NSCLC, approved October 2025 after a phase III head-to-head win over gefitinib.
Mefenamic acid
Mefenamic acid (Ponstel, Ponstan) is a fenamate NSAID, a COX-1/COX-2 inhibitor introduced in the 1960s, used for mild to moderate pain and primary dysmenorrhea, limited to one week, with NSAID boxed warnings.
Mefruside
Mefruside (Baycaron, BAY 1500) is a thiazide-like sulfonamide diuretic, ATC C03BA05, DDD 25 mg oral, developed in Germany in 1968; it inhibits NCC and carbonic anhydrase, raises uric acid, and lowers blood pressure.
Mega-cisterna magna
Mega-cisterna magna (MCM), enlarged cisterna magna over 10 mm anteroposterior with normal cerebellar vermis and no hydrocephalus; a mild Dandy-Walker complex anomaly, usually asymptomatic and incidental.
Mega-trial
A mega-trial is a very large randomized controlled trial, usually enrolling many thousands of patients across many centers, designed to detect modest treatment effects such as 15–20% reductions in death.
Megacolon
Megacolon is abnormal dilatation of the colon, also called congenital megacolon in Hirschsprung disease. Covers toxic megacolon (>6 cm dilation with systemic toxicity), Ogilvie syndrome, and acquired idiopathic megacolon.
Megaconial congenital muscular dystrophy
Megaconial congenital muscular dystrophy (MDCMC), also called CHKB-related muscular dystrophy, is a rare autosomal recessive disorder caused by CHKB variants, marked by enlarged peripheral muscle mitochondria, hypotonia, intellectual disability, ichthyosis, and cardiomyopathy.
Megacystis-megaureter syndrome
Megacystis-megaureter syndrome (mega-ureter-megacystis syndrome, ORPHA:238637, ICD-11 LB31.7) is a rare congenital urinary tract malformation with massive primary vesicoureteral reflux, a large thin-walled bladder, dilated ureters, and recurrent urinary tract infections.