25,729 articles
Mirikizumab
Mirikizumab (Omvoh, mirikizumab-mrkz), Eli Lilly's humanized IgG4 antibody against IL-23 p19, treats moderate-to-severe ulcerative colitis and Crohn's disease; first approved in Japan in March 2023 and by the FDA in October 2023.
Mirizzi syndrome
Mirizzi syndrome: rare gallstone complication in which a stone impacted in Hartmann's pouch or the cystic duct externally compresses the common bile duct, later forming cholecystobiliary fistulas; classified McSherry/Csendes, hard to diagnose preoperatively.
Mirogabalin
Mirogabalin (Tarlige, DS-5565) is a Daiichi Sankyo gabapentinoid α2δ calcium-channel ligand approved in Japan and other Asian countries for neuropathic pain, with slower α2δ-1 dissociation than pregabalin.
Mirror neuron
Mirror neurons, discovered by Rizzolatti's Parma group in macaque area F5, fire both when an animal performs and observes an action; their proposed role in action understanding is heavily contested.
MIRROR study
MIRROR (Mirikizumab Real World Protocol; MIrikizumab in UC - a Real-woRld prOspective multicenteR Registry, NCT06696014) is an observational patient registry sponsored by the University of North Carolina with Eli Lilly, following about 100 adults with ulcerative colitis starting mirikizumab in routine care, with one-year online bowel-habit surveys at nine US and Canadian sites.
Mirror therapy
Mirror therapy is a rehabilitation technique in which a mirror reflects movements of an unaffected limb, developed for phantom limb pain in 1996 and extended to stroke rehabilitation.
Mirror-image polydactyly
Mirror-image polydactyly (mirror foot, mirror hand, ulnar dimelia) is a rare congenital limb malformation with more than five digits arranged symmetrically around an anterior/posterior axis, usually autosomal dominant, linked to ectopic sonic hedgehog signaling and PITX1 deletions.
Mirror-touch synesthesia
Mirror-touch synesthesia is a synesthesia variant in which seeing another person touched produces a felt touch on one's own body; prevalence about 1.6%, explained by threshold and self-other theories, and linked variably to empathy.
Mirtazapine
Mirtazapine (Remeron) is a tetracyclic NaSSA antidepressant approved in the U.S. in 1996; it blocks α2, 5-HT2/5-HT3, and H1 receptors, causing sedation and weight gain, with faster onset than SSRIs.
MIRTPD trial
MIRTPD (NCT07012408) is a double-blind randomized controlled trial by Universitat de les Illes Balears comparing progressive versus regressive return-to-play program design after MRI-diagnosed muscle injury in male football players, N=74, started September 2025.
Mirvetuximab soravtansine
Mirvetuximab soravtansine (Elahere, IMGN853) is a first-in-class antibody-drug conjugate targeting folate receptor alpha, approved for FRα-positive, platinum-resistant ovarian cancer; MIRASOL showed survival benefit over chemotherapy.
Miscarriage
Miscarriage, also called spontaneous abortion or early pregnancy loss, is the loss of a pregnancy before 24 weeks. It occurs in about 10% of clinically recognized pregnancies, is mostly due to chromosomal abnormalities, and is managed expectantly, medically, or surgically.
Misidentification delusion
A misidentification delusion is a fixed, false belief about the identity of people, places, or objects, typically that familiar people have been replaced by identical-looking impostors.
Misitatug blivedotin
Misitatug blivedotin (RC88) is RemeGen's mesothelin-targeting antibody-drug conjugate, a humanized anti-MSLN IgG1 linked to MMAE via a cleavable linker, in phase 1/2 trials for ovarian, lung, and cervical cancers.
Misonidazole
Misonidazole (Ro-07-0582) is a 2-nitroimidazole drug developed by Hoffmann-La Roche as a hypoxic-cell radiosensitizer, first given to patients in 1974; toxicity limited its use, though its radiolabeled analog became a PET tracer.
Misophonia
Misophonia is a disorder of intense anger or disgust triggered by specific sounds like chewing or breathing, first named in 2001, defined by a 2022 Delphi consensus, and treatable with cognitive behavioral therapy.
Misoprostol
Misoprostol, a synthetic prostaglandin E1 analog, is used by the FDA for reducing gastric ulcers. Internationally, it is favored for cervical ripening, labor induction, and treating PPH.
Misraka Sneha
Misraka Sneha (Miśraka sneha) is a classical Ayurvedic medicated ghee from Ashtanga Hridayam (Chikitsa Sthana 14/89-90), made from 21 herbs plus cow ghee and milk, dosed 3 g, used for constipation, abscess, gulma, and vata disorders.
Misreyarka
Misreyarka (Misreya Arka) is an Ayurvedic hydro-distillate prepared from fennel fruit, a member of the Arka kalpana class of distilled medicines, studied in a controlled trial for primary dysmenorrhea.
Missed abortion
Missed abortion, also called missed or silent miscarriage (ICD-11 JA03), is early embryonic or fetal death retained in the uterus without expulsion; diagnosed by ultrasound criteria and managed expectantly, with mifepristone plus misoprostol, or surgically.
Missed Diagnosis
Missed diagnosis: failure to identify a medical condition when a clinician knows the symptoms; one of three diagnostic error types, affecting ~5.7% of ED visits and 0.7% of hospital admissions, causing major preventable harm.
Misshapen ear
Misshapen ear (ICD-11 LA21.3), abnormal shape or position of the outer ear; congenital or acquired. Treated by early infant ear molding (87-92% success) or otoplasty after age 5.
Mission Indradhanush
Mission Indradhanush, India's 2014 catch-up vaccination campaign under the Universal Immunization Programme, targets unvaccinated children and pregnant women in low-coverage districts; its Intensified variant began 2017.
MISTICH trial
MISTICH names two unrelated intracerebral hemorrhage trials: a 2014 Chinese 20-center randomized trial of minimally invasive surgical techniques, and NCT07338175, a recruiting Beijing Tiantan phase III trial of 5-day oral minocycline in 1192 patients.
MiT family translocation renal cell carcinoma
MiT family translocation renal cell carcinoma (tRCC, Xp11/TFE3 or t(6;11)/TFEB translocation RCC): rare kidney cancer defined by TFE3/TFEB gene fusions, 1-5% of adult RCC, ~40% of pediatric RCC, diagnosed by break-apart FISH.
Mitapivat
Mitapivat (AG-348; Pyrukynd, Aqvesme) is an oral first-in-class allosteric activator of red-cell pyruvate kinase, approved 2022 in the US for pyruvate kinase deficiency and 2025 for thalassemia, with sickle cell disease under FDA priority review.
Mitchell Syndrome
Mitchell syndrome (MITCH, OMIM 618960), also called ACOX1 upregulation, an ultra-rare autosomal dominant peroxisomal neurodegenerative disorder from the de novo ACOX1 p.Asn237Ser gain-of-function variant, causing episodic demyelination, polyneuropathy, and hearing loss; distinct from Mitchell–Riley syndrome.
Mitchell W. Spellman
Mitchell W. Spellman, also known as Mitchell Wright Spellman, was an American surgeon and medical educator who served as founding executive dean of the Charles R. Drew Postgraduate Medical School.
Mithridatism
Mithridatism, also called mithridatization, is self-administering gradually increased doses of a poison to gain tolerance, named after Mithridates VI of Pontus; no scientific evidence supports its success, though drug tolerance is real.
Mitiglinide
Mitiglinide (Glufast, GLUBES with voglibose) is a rapid-acting glinide insulin secretagogue for type 2 diabetes, developed by Kissei, marketed in Japan since 2004, acting via SUR1/KATP channel closure.