Human health and medicine

Naluzotan

Naluzotan (PRX-00023), a nonazapirone 5-HT1A receptor partial agonist developed by Predix/EPIX Pharmaceuticals via in silico discovery; failed Phase 3 trials in generalized anxiety disorder and later trials in depression and focal epilepsy, and development was discontinued.

Oct 20, 2026

NAMI trial

The NAMI trial is a Finnish clinical trial at the University of Turku testing whether dietary counseling and probiotics during pregnancy reduce allergy and obesity.

Oct 20, 2026

Nance-Horan syndrome

Nance-Horan syndrome (NHS), cataract-dental syndrome, OMIM 302350: rare X-linked dominant disorder from NHS gene mutations at Xp22.13, causing congenital cataracts, microcornea, screwdriver-shaped incisors, facial dysmorphism, and sometimes intellectual disability.

Nancy King Reame

Nancy King Reame is an American nurse-scientist and Columbia University nursing professor emerita elected to the Institute of Medicine in 1997, known for tampon safety research.

Nancy Nielsen

Nancy Nielsen is an American physician and health policy expert at the University at Buffalo who served as president of the American Medical Association from 2008 to 2009.

Nandrolone

Nandrolone (19-nortestosterone, Deca-Durabolin), an anabolic steroid synthesized in 1950, used as decanoate injections for anemia and osteoporosis, with an 11:1 anabolic-androgenic ratio, WADA prohibition, and 2 ng/ml 19-norandrosterone threshold.

Nanfang Hospital

Nanfang Hospital (南方医科大学南方医院) is a Grade 3A teaching hospital in Guangzhou, First Affiliated Hospital of Southern Medical University; founded 1941 as a New Fourth Army military hospital, 3,601 beds, Fudan A++++ tier.

Nanocapsules

Nanocapsules are hollow 10-200 nm core-shell nanoparticles with a liquid or gaseous core inside a thin polymer or lipid shell, used for triggered drug delivery, cosmetics, food, and agrochemical encapsulation.

Nanoconjugates

Nanoconjugates are tailored macromolecules with covalently attached biologically active modules such as drugs, antibodies, and oligonucleotides that target specific tissues and cells, distinct from encapsulating nanocarriers like liposomes.

Nanocrystal drug delivery

Nanocrystal drug delivery is a formulation approach in which poorly water-soluble drug crystals are reduced to nanometer size and stabilized with surfactants or polymers, raising dissolution rate and bioavailability.

Nanolipogels

Nanolipogels (NLGs) are hybrid drug-delivery nanoparticles made of a crosslinked nanogel core surrounded by a lipid bilayer, combining hydrogel cargo retention with liposome-like biocompatibility.

Nanomedicine

Nanomedicine, also called medical nanotechnology or nanotherapeutics, is the use of nanoscale materials to diagnose, monitor, and treat disease, most visibly in lipid nanoparticle mRNA COVID-19 vaccines.

Nanoparticle aggregation in vivo

Nanoparticle aggregation in vivo is the clumping of nanoparticles once they enter blood or tissue fluid. High ionic strength and protein adsorption drive it, altering biodistribution, pharmacokinetics, and toxicity.

Nanoparticle albumin-bound technology

Nanoparticle albumin-bound (nab) technology is a drug delivery platform that binds poorly water-soluble drugs to human serum albumin; its first product was Abraxane, approved in 2005.

Nanoparticle charge-dependent behavior

Nanoparticle charge-dependent behavior is how a nanocarrier's surface charge, measured as zeta potential, governs which serum proteins adsorb onto it, how readily cells take it up, and how toxic it is.

Nanoparticle crossing of the placental barrier

Nanoparticle crossing of the placental barrier is the translocation of particles 1–100 nm from maternal circulation into placental tissue or the fetus, with size the key determinant.

Nanoparticle margination

Nanoparticle margination is the drift of nanoparticles in flowing blood toward the vessel wall, where they can adhere to the endothelium and deliver drugs to target sites.

Nanoparticle stiffness-dependent behavior

Nanoparticle stiffness-dependent behavior is how a nanoparticle's mechanical rigidity, rather than its size or surface chemistry, shapes circulation, immune clearance, tumor delivery, and cellular uptake.

Nanoparticle-based CAR-T cell engineering

Nanoparticle-based CAR-T cell engineering is a non-viral approach in which lipid nanoparticles deliver CAR genetic material to T cells inside the patient, bypassing the cost and delays of laboratory cell manufacturing.

Sep 29, 2026

Nanoprecipitation

Nanoprecipitation, also known as solvent displacement or antisolvent precipitation, is a one-step method for preparing polymeric nanoparticles, typically 100–300 nm, used to encapsulate hydrophobic drugs.

Nanospheres

Nanospheres are solid spherical nanoparticles, typically 50–1000 nm (gold ones 5–15 nm), without a membrane, used as drug carriers, imaging agents, and lithography masks; distinct from hollow nanocapsules.

Nanosponges

Nanosponges are nanoscale particles with a porous, sponge-like network that trap other molecules, used either for controlled drug delivery or as cell membrane-coated decoys that neutralize bacterial toxins and venom.

NanoTherm

NanoTherm is a magnetic hyperthermia therapy in which iron oxide nanoparticles injected into a tumor are heated to destroy cancer cells, developed by Berlin's MagForce AG.

Nanovaccines

Nanovaccines are nanoparticle-based vaccine platforms (lipid nanoparticles, VLPs, ferritin, OMVs) that protect antigens, target immune cells, and co-deliver adjuvants; approved examples include Comirnaty, SpikeVax, and virosome vaccines.

Nanovalve

A nanovalve is a nanoscale molecular machine on a pore of a mesoporous silica nanoparticle that opens and closes under a stimulus to release cargo molecules.

NANS-CDG

NANS-CDG (OMIM#605202), N-acetylneuraminic acid synthase deficiency, is a rare autosomal recessive congenital disorder of glycosylation causing intellectual disability, short limbs, skeletal dysplasia, thrombocytopenia, and elevated urinary ManNAc; experimental oral sialic acid therapy is under study.